The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Effect of Alcohol (Ethanol) Administration on Sex-Hormone Metabolism in Normal Men
Abstract
To determine whether ethanol per se affects testosterone metabolism, alcohol was administered to normal male volunteers for periods up to four weeks, resulting in an initial dampening of the episodic bursts of testosterone secretion followed by decreases in both the mean plasma concentration and the production rate of testosterone. The volunteers received adequate nutrition and none lost weight during the study, which tended to exclude a nutritional disturbance as the cause of the decreased testosterone levels. The changes in plasma luteinizing hormone suggested both a central (hypothalamus-pituitary) and gonadal effect of alcohol. In addition, alcohol consumption increased the metabolic clearance rate of testosterone in most subjects studied, probably owing to the combined effects of a decreased plasma binding capacity for the androgen and increased hepatic testosterone A-ring reductase activity. These results indicate that alcohol markedly affects testosterone metabolism independently of cirrhosis or nutritional factors.
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Cites
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Cited by
Smoke, alcohol and drug addiction and male fertility
Sansone, A., Di Dato, C., de Angelis, C., Menafra, D., Pozza, C., Pivonello, R., Isidori, A., & Gianfrilli, D. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0320-7 · Cited by 324
Familial factors affecting prostatic cancer risk and plasma sex-steroid levels
Wayne Meikle, A., Smith, J. A., & West, D. W. (1985) · The Prostate · doi:10.1002/pros.2990060202 · Cited by 110
Ida, Y., Tsujimaru, S., Nakamaura, K., Shirao, I., Mukasa, H., Egami, H., & Nakazawa, Y. (1992) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(92)90009-2 · Cited by 85
Effects of Acute Alcohol Administration on Reproductive Endocrinology in the Male Rat
Cicero, T. J., Bernstein, D., & Badger, T. M. (1978) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1978.tb05807.x · Cited by 82
The chronic alcohol consumption influences the gonadal axis in men: Results from a meta‐analysis
Santi, D., Cignarelli, A., Baldi, M., Sansone, A., Spaggiari, G., Simoni, M., & Corona, G. (2024) · Andrology · doi:10.1111/andr.13526 · Cited by 17
Metadata
- Authors
- Gordon, G. G., Altman, K., Southren, A. L., Rubin, E., & Lieber, C. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-10-07
- Volume
- 295
- Issue
- 15
- Pages
- 793-797
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2011252627
- Cited by
- 364
- References
- 24
- FWCI
- 18.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gordon, G. G., Altman, K., Southren, A. L., Rubin, E., & Lieber, C. S. (1976). Effect of Alcohol (Ethanol) Administration on Sex-Hormone Metabolism in Normal Men. New England Journal of Medicine. https://doi.org/10.1056/nejm197610072951501
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
