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Serum Lipids in Infection
Abstract
Abstract Striking elevations in concentrations of total serum lipids were observed in patients with infection caused by gram-negative bacilli. The elevated levels of total lipid in these patients were due mainly to marked increases in serum concentrations of triglycerides or free fatty acids or both. In contrast, patients with severe infection caused by gram-positive cocci had normal concentrations of total serum lipids. Those with fever but no infection and those with influenza had normal concentrations of total serum lipids and normal levels of the major lipid classes. Patients with infectious or serum hepatitis demonstrated a moderate hyperlipidemia, which resulted from increased concentrations of serum triglycerides and free cholesterol. Lipoprotein electrophoresis demonstrated that the hyperlipidemia in patients with severe infection caused by gram-negative bacilli was related to increased levels of pre-beta-lipoproteins. In patients with hepatitis there were increased levels of pre-beta-lipoproteins...
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Cited by
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 935
Grunfeld, C. (1992) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.74.5.1045 · Cited by 848
Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo.
Feingold, K. R., & Grunfeld, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113046 · Cited by 403
Feingold, K., Staprans, I., Memon, R., Moser, A., Shigenaga, J., Doerrler, W., Dinarello, C., & Grunfeld, C. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41334-3 · Cited by 346
Metadata
- Authors
- Gallin, J. I., Kaye, D., & O'Leary, W. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1969-11-13
- Volume
- 281
- Issue
- 20
- Pages
- 1081-1086
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337410076
- Cited by
- 370
- References
- 0
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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