The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo.
Open accessAbstract
The hyperlipidemia accompanying infection has been attributed to production of tumor necrosis factor. This cytokine inhibits adipose tissue lipoprotein lipase, which could decrease clearance of lipoproteins. Infections also increase hepatic lipogenesis. We now have demonstrated that tumor necrosis factor-alpha stimulates lipid synthesis in vivo. 2 h after administration of tumor necrosis factor (25 micrograms/200 g), plasma triglycerides increase 2.2-fold and remain elevated for 17 h. Plasma cholesterol also increases, but this effect appears after 7 h. Tumor necrosis factor rapidly stimulates incorporation of tritiated water into fatty acids in the liver (1-2 h), which persists for 17 h. Also, tumor necrosis factor stimulates hepatic sterol synthesis. Of note, tumor necrosis factor treatment does not stimulate lipid synthesis in other tissues, including adipose tissue. Labeled fatty acids rapidly increase in the plasma, raising the possibility that stimulation of hepatic lipogenesis by tumor necrosis factor contributes to the hyperlipidemia of infection.
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Cites
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Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
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Cachectin and tumour necrosis factor as two sides of the same biological coin
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Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
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Metabolic Response to Infection
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Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells.
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Cited by
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754
National Health and Nutrition Examination Survey
(2010) · Handbook of Disease Burdens and Quality of Life Measures · doi:10.1007/978-0-387-78665-0_6177 · Cited by 2,087
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481
Self-citationPeroxisomes and oxidative stress
Schrader, M., & Fahimi, H. D. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.09.006 · Cited by 838
Metadata
- Authors
- Feingold, K. R., & Grunfeld, C.
- Venue
- Journal of Clinical Investigation
- Published
- 1987-07-01
- Volume
- 80
- Issue
- 1
- Pages
- 184-190
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2055054372
- Cited by
- 403
- References
- 19
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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