The DOI matches its Crossref record.
Mitochondrial Ultrastructure in Reye's Syndrome (Encephalopathy and Fatty Degeneration of the Viscera)
Abstract
Abstract Electron microscopy was performed on liver-biopsy tissue obtained early in the evolution of Reye's syndrome and during recovery in an effort to identify the main site (or sites) of cell injury. Early in the course of encephalopathy, hepatocytes are universally affected by a process that results in mitochondrial swelling and pleomorphism as well as small-droplet triglyceride accumulation. During recovery, mitochondrial morphology improves in parallel with clinical improvement. A chemically mediated, potentially reversible mitochondrial injury may be instrumental in the evolution of Reye's syndrome.
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Cited by
Lemasters, J. J., Nieminen, A.-L., Qian, T., Trost, L. C., Elmore, S. P., Nishimura, Y., Crowe, R. A., Cascio, W. E., Bradham, C. A., Brenner, D. A., et al. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00112-1 · Cited by 1,387
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
Fromenty, B., & Pessayre, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00012-6 · Cited by 665
Rothbaum, R., Mcadams, A. J., Giannella, R., & Partin, J. C. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80342-9 · Cited by 349
Self-citationMegamitochondria formation ‐ physiology and pathology
Wakabayashi, T. (2002) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2002.tb00452.x · Cited by 189
TANDLER, B., & HOPPEL, C. L. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb46548.x · Cited by 89
Metadata
- Authors
- Partin, J. C., Schubert, W. K., & Partin, J. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1971-12-09
- Volume
- 285
- Issue
- 24
- Pages
- 1339-1343
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320195876
- Cited by
- 269
- References
- 0
- FWCI
- 15.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Partin, J. C., Schubert, W. K., & Partin, J. S. (1971). Mitochondrial Ultrastructure in Reye's Syndrome (Encephalopathy and Fatty Degeneration of the Viscera). New England Journal of Medicine. https://doi.org/10.1056/nejm197112092852402
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
