Studies on giant mitochondria
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Enlarged mitochondria indicative of dyshomeostasis between fusion and fission have been documented in aging muscles.
“enlarged mitochondria indicative of dyshomeostasis between fusion and fission (i.e. greater fusion and/or lower fission events) have previously been documented in aging muscles.(Tandler and Hoppel 1986)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Tandler and Hoppel 1986
Numerous studies have reported the accumulation of enlarged or highly interconnected mitochondria in aging cells.
“Consistent with a relationship between mitochondrial dynamics and aging, numerous studies have reported the accumulation of enlarged (often referred to as ‘giant’) or highly interconnected mitochondria in aging cells (Murakoshi et al., 1985; Tandler and Hoppel, 1986).”
From New insights into the role of mitochondria in aging: mitochondrial dynamics and more (2010) · cites this paper as Tandler and Hoppel, 1986
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Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging
Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245 · see citing works
New insights into the role of mitochondria in aging: mitochondrial dynamics and more
Seo, A. Y., Joseph, A.-M., Dutta, D., Hwang, J. C. Y., Aris, J. P., & Leeuwenburgh, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.070490 · Cited by 522 · see citing works
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
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Successful aging: Advancing the science of physical independence in older adults
Anton, S. D., Woods, A. J., Ashizawa, T., Barb, D., Buford, T. W., Carter, C. S., Clark, D. J., Cohen, R. A., Corbett, D. B., Cruz-Almeida, Y., et al. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.005 · Cited by 292 · see citing works
Sogo, L. F., & Yaffe, M. P. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.6.1361 · Cited by 284 · see citing works
Joseph, A., Adhihetty, P. J., & Leeuwenburgh, C. (2016) · The Journal of Physiology · doi:10.1113/jp270659 · Cited by 186 · see citing works
Joseph, A.-M., Adhihetty, P. J., Wawrzyniak, N. R., Wohlgemuth, S. E., Picca, A., Kujoth, G. C., Prolla, T. A., & Leeuwenburgh, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069327 · Cited by 161 · see citing works
Metabolic features and regulation in cell senescence
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“or highly interconnected mitochondria have often been reported in cirrhotic livers and in several aged tissues (28, 29).”
Background
- Authors
- TANDLER, B., & HOPPEL, C. L.
- Affiliations
- Case Western Reserve University (US)
- ORCID
- HOPPEL, CHARLES L.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 1986-12
- Volume
- 488
- Issue
- 1 Membrane Path
- Pages
- 65-81
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2051653292
- Cited by
- 89
- References
- 50
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 5 · 2012: 3
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- giant mitochondria, mitochondrial morphology, mitochondrial ultrastructure
- MeSH terms
- Aging, Ethanol, Animals, Cuprizone, Hormones, Humans, Microscopy, Electron, Mitochondria, Mitochondria, Liver, Nutrition Disorders, Riboflavin Deficiency
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