The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dissolution of Cholesterol Gallstones by Chenodeoxycholic Acid
Abstract
Seven women with gallstones were given 0.75 to 4.5 g per day of chenodeoxycholic acid, a primary bile acid, to promote micellar solubilization of cholesterol in bile. In Case 1 three stones that had remained unchanged in size during six years of observations disappeared after six months of treatment. A single stone in Case 2 and multiple calculi in Cases 3 and 4 progressively grew smaller during 14 to 22 months of chenodeoxycholic acid administration. Gallstone size did not change in the other three. Chenodeoxycholic acid and total bile acid pool sizes (measured in two patients), which were reduced before therapy, were markedly expanded by chenodeoxycholic acid, and the ratio of bile acids and lecithin to cholesterol in bile increased in all patients. Liver function and morphology remained normal; moderate dose-related diarrhea occurred. Chenodeoxycholic acid may offer medical treatment for cholesterol cholelithiasis in man.
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Citations
Cites
Colonic Secretion of Water and Electrolytes Induced by Bile Acids: Perfusion Studies in Man
Mekhjian, H. S., Phillips, S. F., & Hofmann, A. F. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106644 · Cited by 584
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Cited by
Bile-acid-induced cell injury and protection
Perez, M. J., & Briz, O. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.1677 · Cited by 717
Carey, M. C., & Small, D. M. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109025 · Cited by 699
Portincasa, P., Moschetta, A., & Palasciano, G. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69044-2 · Cited by 643
Molecular physiology of bile acid signaling in health, disease, and aging
Perino, A., Demagny, H., Velazquez-Villegas, L., & Schoonjans, K. (2021) · Physiological Reviews · doi:10.1152/physrev.00049.2019 · Cited by 481
Ursodeoxycholic Acid: A Safe and Effective Agent for Dissolving Cholesterol Gallstones
TINT, G. S., SALEN, G., COLALILLO, A., GRABER, D., VERGA, D., SPECK, J., & SHEFER, S. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-97-3-351 · Cited by 121
Metadata
- Authors
- Danzinger, R. G., Hofmann, A. F., Schoenfield, L. J., & Thistle, J. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1972-01-06
- Volume
- 286
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337742529
- Cited by
- 648
- References
- 1
- FWCI
- 94.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Danzinger, R. G., Hofmann, A. F., Schoenfield, L. J., & Thistle, J. L. (1972). Dissolution of Cholesterol Gallstones by Chenodeoxycholic Acid. New England Journal of Medicine. https://doi.org/10.1056/nejm197201062860101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
