Iodide-Induced Thyrotoxicosis in Boston
Abstract
Abstract The syndrome of iodide-induced hyperthyroidism (Jodbasedow) is not common and has been reported to occur in patients with iodine-deficient goiter after iodide replenishment. As part of a larger study to assess the effects of iodide administration on thyroid hormone synthesis in normal subjects and in patients with various underlying disorders of the thyroid, iodides (5 drops of a saturated solution of potassium iodide) were administered to eight patients with nontoxic goiter residing in Boston, an area of iodine sufficiency. Hyperthyroidism developed during and after iodide administration in four of the eight — an unexpectedly high frequency. This finding suggests that the homeostatic mechanism controlling thyroid hormone synthesis and release in these patients is not functioning normally. We recommend that large doses of iodides not be administered to patients with nontoxic goiter.
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Reports of escape from the beneficial effects of iodine and reports of iodine-induced hyperthyroidism in patients with nodular goiter discouraged the use of iodine in GD.
“However, reports of escape from these beneficial effects of iodine (241) as well as reports of iodine-induced hyperthyroidism in patients with nodular goiter (242) discouraged the use of iodine in GD.”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [242]
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Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938 · see citing works
“However, reports of escape from these beneficial effects of iodine (241) as well as reports of iodine-induced hyperthyroidism in patients with nodular goiter (242) discouraged the use of iodine in GD.”
BackgroundIodine-Induced Hyperthyroidism: Occurrence and Epidemiology
STANBURY, J. B., ERMANS, A. E., BOURDOUX, P., TODD, C., OKEN, E., TONGLET, R., VIDOR, G., BRAVERMAN, L. E., & MEDEIROS-NETO, G. (1998) · Thyroid · doi:10.1089/thy.1998.8.83 · Cited by 415 · see citing works
Self-citationBürgi, H. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.08.010 · Cited by 249 · see citing works
Rhee, C. M. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.677 · Cited by 222 · see citing works
Amiodarone-Induced Thyrotoxicosis
Daniels, G. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7119 · Cited by 159 · see citing works
SYNDROMES OF THYROTOXICOSIS WITH LOW RADIOACTIVE IODINE UPTAKE
Ross, D. S. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70305-4 · Cited by 100 · see citing works
BRENNAN, M. D., ERICKSON, D. Z., CARNEY, J. A., & BAHN, R. S. (1995) · Thyroid · doi:10.1089/thy.1995.5.177 · Cited by 61 · see citing works
Okamura, K., Sato, K., Fujikawa, M., Bandai, S., Ikenoue, H., & Kitazono, T. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4466 · Cited by 64 · see citing works
- Authors
- Vagenakis, A. G., Wang, C.-A., Burger, A., Maloof, F., Braverman, L. E., & Ingbar, S. H.
- Affiliations
- Tufts University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1972-09-14
- Volume
- 287
- Issue
- 11
- Pages
- 523-527
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2313169400
- Cited by
- 186
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- potassium iodide, nontoxic goiter, iodine sufficiency, thyroid hormone synthesis, thyroid homeostasis
- MeSH terms
- Adult, Boston, Female, Goiter, Humans, Hyperthyroidism, Iodides, Iodine Radioisotopes, Middle Aged, Potassium Iodide, Thyroid Function Tests, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine
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