The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Migration of a Phthalate Ester Plasticizer from Polyvinyl Chloride Blood Bags into Stored Human Blood and Its Localization in Human Tissues
Abstract
A plasticizer, di-2-ethylhexyl phthalate, was found to be extracted from polyvinyl chloride plastic blood bags by both human and dog blood stored at 4°C at a rate of 0.25 ± 0.03 mg per 100 ml per day. Plasticizer was found in both the lipid-containing and lipid-free fractions of plasma whereas red cells contained only minor amounts. Seven of 12 lung-tissue samples taken at autopsy from patients who had received transfusions of stored blood contained detectable amounts of plasticizer. One patient, after open-heart surgery, excreted a urinary metabolite of the plasticizer in excess of the amount calculated to have been received in the transfused blood. The additional metabolite possibly came from plasticizer extracted from the polyvinyl chloride tubing of the cardiopulmonary unit. Although the toxicologic implications of these observations are not currently known, it is suggested that plastic formulations that do not contribute any extractable materials to blood or its fractions be developed.
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Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Plasticizers from Plastic Devices: Extraction, Metabolism, and Accumulation by Biological Systems
Jaeger, R. J., & Rubin, R. J. (1970) · Science · doi:10.1126/science.170.3956.460 · Cited by 348
Self-citationToxicology of a Series of Phthalate Esters
Calley, D., Autian, J., & Guess, W. L. (1966) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600550206 · Cited by 154
Nazir, D. J., Alcaraz, A. P., Bierl, B. A., Beroza, M., & Nair, P. P. (1971) · Biochemistry · doi:10.1021/bi00799a012 · Cited by 95
Toxicity of Ethylene Chlorohydrin I: Acute Toxicity Studies
Lawrence, W. H., Turner, J. E., & Autian, J. (1971) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600600411 · Cited by 31
Cited by
The estrogenic activity of phthalate esters in vitro.
Harris, C. A., Henttu, P., Parker, M. G., & Sumpter, J. P. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105802 · Cited by 835
Doull, J., Cattley, R., Elcombe, C., Lake, B. G., Swenberg, J., Wilkinson, C., Williams, G., & van Gemert, M. (1999) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.1999.1296 · Cited by 337
Huber, W. W., Grasl-kraupp, B., & Schulte-hermann, R. (1996) · Critical Reviews in Toxicology · doi:10.3109/10408449609048302 · Cited by 302
Exposure to Di-(2-Ethylhexyl) Phthalate Among Premature Neonates in a Neonatal Intensive Care Unit
Calafat, A. M., Needham, L. L., Silva, M. J., & Lambert, G. (2004) · Pediatrics · doi:10.1542/peds.113.5.e429 · Cited by 263
Peck, C. C., & Albro, P. W. (1982) · Environmental Health Perspectives · doi:10.1289/ehp.824511 · Cited by 127
Metadata
- Authors
- Jaeger, R. J., & Rubin, R. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1972-11-30
- Volume
- 287
- Issue
- 22
- Pages
- 1114-1118
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2015697520
- Cited by
- 400
- References
- 5
- FWCI
- 20.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Migration of a Phthalate Ester Plasticizer from Polyvinyl Chloride Blood Bags into Stored Human Blood and Its Localization in Human Tissues. https://app.cochat.ai/papers/10.1056/nejm197211302872203
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- Jaeger, R. J., & Rubin, R. J. (1972). Migration of a Phthalate Ester Plasticizer from Polyvinyl Chloride Blood Bags into Stored Human Blood and Its Localization in Human Tissues. New England Journal of Medicine. https://doi.org/10.1056/nejm197211302872203
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
