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Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic Carcinoma
Abstract
Aryl hydrocarbon hydroxylase is an inducible, membrane-bound enzyme involved in the metabolism of chemical carcinogens. In cultured human lymphocytes there is genetic variation. The normal white population in the United States can be divided into three separate groups having low, intermediate, and high inducible aryl hydrocarbon hydroxylase activities, with frequencies of 44.7 per cent, 45.9 per cent and 9.4 per cent respectively. Fifty patients with bronchogenic carcinoma were studied, and the frequencies of the three groups were 4.0 per cent, 66.0 per cent and 30.0 per cent respectively. The data indicate that susceptibility to bronchogenic carcinoma is associated with the higher levels of inducible aryl hydrocarbon hyroxylase activity. (N Engl J Med 289:934–937, 1973)
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Citations
Cited by
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NEBERT, D. W., PUGA, A., & VASILIOU, V. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35928.x · Cited by 423
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Townsend, E. A., Miller, V. M., & Prakash, Y. S. (2012) · Endocrine Reviews · doi:10.1210/er.2010-0031 · Cited by 395
Contributions of Human Enzymes in Carcinogen Metabolism
Rendic, S., & Guengerich, F. P. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300132k · Cited by 279
Metabolic activation of carcinogens
Peter Guengerich, F. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90050-a · Cited by 274
Metadata
- Authors
- Kellermann, G., Shaw, C. R., & Luyten-Kellerman, M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1973-11
- Volume
- 289
- Issue
- 18
- Pages
- 934-937
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2002301710
- Cited by
- 591
- References
- 0
- FWCI
- 34.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kellermann, G., Shaw, C. R., & Luyten-Kellerman, M. (1973). Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic Carcinoma. New England Journal of Medicine. https://doi.org/10.1056/nejm197311012891802
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