The DOI matches its Crossref record; 314 of the 314 references it cites were found in a registry or an index.
Contributions of Human Enzymes in Carcinogen Metabolism
Open accessAbstract
Considerable support exists for the roles of metabolism in modulating the carcinogenic properties of chemicals. In particular, many of these compounds are pro-carcinogens that require activation to electrophilic forms to exert genotoxic effects. We systematically analyzed the existing literature on the metabolism of carcinogens by human enzymes, which has been developed largely in the past 25 years. The metabolism and especially bioactivation of carcinogens are dominated by cytochrome P450 enzymes (66% of bioactivations). Within this group, six P450s--1A1, 1A2, 1B1, 2A6, 2E1, and 3A4--accounted for 77% of the P450 activation reactions. The roles of these P450s can be compared with those estimated for drug metabolism and should be considered in issues involving enzyme induction, chemoprevention, molecular epidemiology, interindividual variations, and risk assessment.
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Self-citationPharmacogenomics: Translating Functional Genomics into Rational Therapeutics
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Self-citationOxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
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Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects
Bolton, J. L., & Dunlap, T. (2017) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00256 · Cited by 522
Rendic, S., & Guengerich, F. P. (2015) · Chemical Research in Toxicology · doi:10.1021/tx500444e · Cited by 477
Self-citationChen, S., Wu, Q., Li, X., Li, D., Mei, N., Ning, B., Puig, M., Ren, Z., Tolleson, W. H., & Guo, L. (2021) · Journal of Environmental Science and Health, Part C · doi:10.1080/26896583.2021.1880242 · Cited by 44
Metadata
- Authors
- Rendic, S., & Guengerich, F. P.
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-10
- Volume
- 25
- Issue
- 7
- Pages
- 1316-1383
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W1998118464
- Cited by
- 279
- References
- 314
- FWCI
- 22.61
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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