The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Influence of Disodium Etidronate on Clinical and Laboratory Manifestations of Paget's Disease of Bone (Osteitis Deformans)
Abstract
A six-month double-blind controlled study was performed to determine effectiveness and dose response of disodium etidronate on Paget's disease (osteitis deformans). Forty-seven subjects were studied with pain related to radiologically documented Paget's bone sites as well as marked elevation of serum alkaline phosphatase and hydroxyproline excretion. There was significant (p<0.05) reduction of alkaline phosphatase, hydroxyproline and radiofluoride or radiostrontium uptake over Paget's bone lesions after orally administered disodium etidronate at doses of 5, 10 and 20 mg per kilogram per day for six months. There was a dose-response relation of administered disodium etidronate to improvement of pain, with moderate or marked improvement of pain in six of seven subjects on 20 mg per kilogram per day. In all dosage groups the most marked relief of pain was at sites of Paget's involvement of long bones. Apparent side effects were limited to occasional abdominal cramps. (N Engl J Med 289:1379–1384, 1973)
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Citations
Cites
The inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and polyphosphates
Francis, M. D. (1969) · Calcified Tissue Research · doi:10.1007/bf02058658 · Cited by 399
Cited by
Flanagan, A. M., & Chambers, T. J. (1991) · Calcified Tissue International · doi:10.1007/bf02555852 · Cited by 171
Management of Paget's disease of bone
Langston, A. L. (2004) · Rheumatology · doi:10.1093/rheumatology/keh243 · Cited by 124
Cundy, T. (2018) · Metabolism · doi:10.1016/j.metabol.2017.06.010 · Cited by 76
Metadata
- Authors
- Altman, R. D., Johnston, C. C., Khairi, M. R. A., Wellman, H., Serafini, A. N., & Sankey, R. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1973-12-27
- Volume
- 289
- Issue
- 26
- Pages
- 1379-1384
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337075852
- Cited by
- 248
- References
- 1
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Influence of Disodium Etidronate on Clinical and Laboratory Manifestations of Paget's Disease of Bone (Osteitis Deformans). https://app.cochat.ai/papers/10.1056/nejm197312272892601
- The paper
- Altman, R. D., Johnston, C. C., Khairi, M. R. A., Wellman, H., Serafini, A. N., & Sankey, R. R. (1973). Influence of Disodium Etidronate on Clinical and Laboratory Manifestations of Paget's Disease of Bone (Osteitis Deformans). New England Journal of Medicine. https://doi.org/10.1056/nejm197312272892601
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
