Paget's disease of bone

Cundy, Tim

doi:10.1016/j.metabol.2017.06.010

Cited by 76Bone Metabolism and DiseasesBone health and treatmentsBone health and osteoporosis research

Paget's disease of bone

Cundy, Tim·2018·Metabolism

DOI 10.1016/j.metabol.2017.06.010

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Abstract

Paget's disease is a chronic focal high turnover bone disorder that is primarily present in middle-aged or older adults. It seems to be restricted to humans and has no clear parallels with other diseases. Although much has been learnt about its pathology and epidemiology, and treatment is now highly effective we still lack a complete understanding of its etiology and biology. This review focusses on the natural history of the disorder, in particular its changing epidemiology, recent discoveries about its genetic basis and current approaches to diagnosis and treatment. While there is strong evidence for genetic predisposition to Paget's disease, there is also compelling evidence that it is becoming less prevalent, the age of patients at presentation is increasing and that the extent of skeletal involvement is diminishing, implying that there is an important, but as yet unidentified, environmental factor in its etiology. Contemporary patients are typically elderly and have few bones involved. Treatment with potent intravenous bisphosphonates provides prolonged remission and many will require only once in a lifetime treatment.

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Malignant transformation to osteosarcoma is estimated to occur in about 1% of patients with Paget disease.
“it is estimated that malignant transformation to osteosarcoma occurs in ~1% of patients with Paget disease 26 .”
From Osteosarcoma (2022) · cites this paper as [26]
In older adults, osteosarcomas may arise in the setting of Paget disease and other bone disorders, suggesting a role of abnormal bone turnover in osteosarcoma pathogenesis.
“Particularly in older adults, osteosarcomas may also arise in the setting of Paget disease of bone and other bone disorders, suggesting a role of abnormal bone turnover in osteosarcoma pathogenesis 26 .”
From Osteosarcoma (2022) · cites this paper as [26]

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy
Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578 · see citing works
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276 · see citing works
The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma
Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,499 · see citing works
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
Watts, G. D. J., Wymer, J., Kovach, M. J., Mehta, S. G., Mumm, S., Darvish, D., Pestronk, A., Whyte, M. P., & Kimonis, V. E. (2004) · Nature Genetics · doi:10.1038/ng1332 · Cited by 1,391 · see citing works
Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation
Seibenhener, M. L., Babu, J. R., Geetha, T., Wong, H. C., Krishna, N. R., & Wooten, M. W. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.8055-8068.2004 · Cited by 710 · see citing works
On a Form of Chronic Inflammation of Bones (Osteitis Deformans)
Paget, J. T.-E. H. (1877) · Journal of the Royal Society of Medicine · doi:10.1177/095952877706000105 · Cited by 582 · see citing works
Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.
Laurin, N., Brown, J. P., Morissette, J., & Raymond, V. (2002) · The American Journal of Human Genetics · doi:10.1086/340731 · Cited by 563 · see citing works
Comparison of a Single Infusion of Zoledronic Acid with Risedronate for Paget's Disease
Reid, I. R., Miller, P. D., Lyles, K. W., Fraser, W. D., Brown, J. P., Saïdi, Y., Mesenbrink, P. G., Su, G., Pak, J., Zelenakas, K., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044241 · Cited by 437 · see citing works
Subacute sclerosing panencephalitis
Garg, R. K. (2002) · Postgraduate Medical Journal · doi:10.1136/pmj.78.916.63 · Cited by 400 · see citing works
Giant Osteoclast Formation and Long-Term Oral Bisphosphonate Therapy
Weinstein, R. S., Roberson, P. K., & Manolagas, S. C. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0802633 · Cited by 391 · see citing works
Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget’s disease.
Hocking, L. J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.22.2735 · Cited by 350 · see citing works
The Atypical PKC-Interacting Protein p62 Is an Important Mediator of RANK-Activated Osteoclastogenesis
Durán, A., Serrano, M., Leitges, M., Flores, J. M., Picard, S., Brown, J. P., Moscat, J., & Diaz-Meco, M. T. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00403-9 · Cited by 316 · see citing works
Pathophysiology and Treatment of Paget's Disease of Bone
Kanis, J. А. (1991) · Medical Entomology and Zoology · Cited by 315 · see citing works
Signal integration and diversification through the p62 scaffold protein
Moscat, J., Díaz-Meco, M. T., & WOOTEN, M. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.12.002 · Cited by 315 · see citing works
Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
Babu, J. R., Geetha, T., & Wooten, M. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03181.x · Cited by 315 · see citing works
Molecular perspectives on p97–VCP: progress in understanding its structure and diverse biological functions
Wang, Q., Song, C., & Li, C.-C. H. (2003) · Journal of Structural Biology · doi:10.1016/j.jsb.2003.11.014 · Cited by 299 · see citing works
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
Rodriguez, A., Durán, A., Selloum, M., Champy, M.-F., Diez-Guerra, F. J., Flores, J. M., Serrano, M., Auwerx, J., Diaz-Meco, M. T., & Moscat, J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.011 · Cited by 290 · see citing works
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone
Albagha, O., Visconti, M. R., Alonso, N., Langston, A. L., Cundy, T., Dargie, R., Dunlop, M. G., Fraser, W. D., Hooper, M. J., Isaia, G., et al. (2010) · Nature Genetics · doi:10.1038/ng.562 · Cited by 280 · see citing works
Self-citation
Über Ostitis deformans Paget
Schmorl, G. (1932) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01887990 · Cited by 270 · see citing works
Lysine 63‐linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome
Saeki, Y., Kudo, T., Sone, T., Kikuchi, Y., Yokosawa, H., Toh‐e, A., & Tanaka, K. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.305 · Cited by 260 · see citing works
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration
Ramesh Babu, J., Lamar Seibenhener, M., Peng, J., Strom, A., Kemppainen, R., Cox, N., Zhu, H., Wooten, M. C., Diaz‐Meco, M. T., Moscat, J., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05340.x · Cited by 258 · see citing works
Influence of Disodium Etidronate on Clinical and Laboratory Manifestations of Paget's Disease of Bone (Osteitis Deformans)
Altman, R. D., Johnston, C. C., Khairi, M. R. A., Wellman, H. N., Serafini, A. N., & Sankey, R. R. (1973) · New England Journal of Medicine · doi:10.1056/nejm197312272892601 · Cited by 248 · see citing works
The Epidemiology of Paget's Disease in Britain: Is the Prevalence Decreasing?
Cooper, C. C., Schafheutle, K., Dennison, E., et al. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.2.192 · Cited by 245 · see citing works
Valosin-containing protein disease: Inclusion body myopathy with Paget’s disease of the bone and fronto-temporal dementia
Weihl, C. C., Pestronk, A., & Kimonis, V. E. (2009) · Neuromuscular Disorders · doi:10.1016/j.nmd.2009.01.009 · Cited by 236 · see citing works
Structure and functional properties of the ubiquitin binding protein p62
Geetha, T., & Wooten, M. W. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02286-x · Cited by 223 · see citing works
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
Jin, W., Chang, M., Paul, E. M., Babu, G. R., Lee, A. J., Reiley, W. W., Wright, A., Zhang, M., You, J., & Sun, S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34257 · Cited by 195 · see citing works
Sarcomas of bone complicating osteitis deformans (Pagetʼs disease)
Wick, M. R., McLeod, R. A., Siegal, G. P., et al. (1981) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198101000-00008 · Cited by 184 · see citing works
Biochemical and radiologic improvement in Paget's disease of bone treated with alendronate: A randomized, placebo-controlled trial
Reid, I. R., Nicholson, G. C., Weinstein, R. S., Hosking, D. J., Cundy, T., Kotowicz, M. A., Murphy, W. A., Yeap, S. S., Dufresne, S., Lombardi, A., et al. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00227-6 · Cited by 177 · see citing works
Self-citation
EFFECTS OF CALCITONIN ON PATIENTS WITH PAGET'S DISEASE, THYROTOXICOSIS, OR HYPERCALCÆMIA
Bijvoet, O. L. M., Veer, J. V. D. S., & Jansen, A. P. H. (1968) · The Lancet · doi:10.1016/s0140-6736(68)90236-5 · Cited by 176 · see citing works
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone
Albagha, O., Wani, S. E., Visconti, M. R., Alonso, N., Ralston, S. H., Goodman, K., Brandi, M. L., Falchetti, A., Cundy, T., Chung, P. Y. J., et al. (2011) · Nature Genetics · doi:10.1038/ng.845 · Cited by 175 · see citing works
Self-citation
Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia
Kimonis, V. E., Mehta, S. G., Fulchiero, E. C., Thomasová, D., Pasquali, M., Boycott, K. M., Neilan, E. G., Kartashov, A. I., Forman, M. S., Tucker, S., et al. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31862 · Cited by 174 · see citing works
Novel UBA Domain Mutations of SQSTM1 in Paget's Disease of Bone: Genotype Phenotype Correlation, Functional Analysis, and Structural Consequences
Hocking, L. J., Lucas, G. J., Daroszewska, A., Cundy, T., Nicholson, G. C., Donath, J., Walsh, J. P., Finlayson, C., Cavey, J. R., Ciani, B., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0403015 · Cited by 156 · see citing works
Self-citation
Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget’s disease of bone.
Menaa, C., Reddy, S. V., Kurihara, N., Maeda, H., Anderson, D., Cundy, T., Cornish, J., Singer, F. R., Bruder, J. M., & Roodman, G. D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9133 · Cited by 154 · see citing works
Self-citation
Sequestosome 1: Mutation Frequencies, Haplotypes, and Phenotypes in Familial Paget's Disease of Bone
Morissette, J., Laurin, N., & Brown, J. P. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.06s207 · Cited by 151 · see citing works
Genetic Linkage of Paget Disease of the Bone to Chromosome 18q
Cody, J. D., Singer, F. R., Roodman, G. D., Otterund, B., Lewis, T. B., Leppert, M., & Leach, R. J. (1997) · The American Journal of Human Genetics · doi:10.1086/301601 · Cited by 151 · see citing works
Epidemiology of Paget's Disease in Europe: The Prevalence Is Decreasing
Poór, G., Donáth, J., Fornet, B., & Cooper, C. C. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060704 · Cited by 141 · see citing works
Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype
Kurihara, N., Reddy, S. V., Menaa, C., Anderson, D., & Roodman, G. D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8489 · Cited by 141 · see citing works
Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality
Müller, J. M. M., Deinhardt, K., Rosewell, I., Warren, G., & Shima, D. T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.206 · Cited by 133 · see citing works
Epidemiology of Paget's disease of bone: A systematic review and meta-analysis of secular changes
Corral-Gudino, L., Borao‐Cengotita‐Bengoa, M., del Pino‐Montes, J., et al. (2013) · Bone · doi:10.1016/j.bone.2013.04.024 · Cited by 133 · see citing works
Epidemiological aspects of Paget's disease: Family history and relationship to other medical conditions
Siris, E. S. (1994) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(94)90037-x · Cited by 132 · see citing works
A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice
Daroszewska, A., van 't Hof, R. J., Rojas, J. A., Layfield, R., Landao-Basonga, E., Rose, L., Rose, K., & Ralston, S. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr172 · Cited by 131 · see citing works
A single infusion of zoledronic acid produces sustained remissions in paget disease: Data to 6.5 years
Reid, I. R., Lyles, K. W., Su, G., Brown, J. P., Walsh, J. P., del Pino‐Montes, J., Miller, P. D., Fraser, W. D., Cafoncelli, S., Bucci-Rechtweg, C. M., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.438 · Cited by 130 · see citing works
Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease
Kurihara, N., Hiruma, Y., Zhou, H., Subler, M. A., Dempster, D. W., Singer, F. R., Reddy, S. V., Gruber, H. E., Windle, J. J., & Roodman, G. D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28267 · Cited by 127 · see citing works
Idiopathic Hyperphosphatasia and TNFRSF11B Mutations: Relationships Between Phenotype and Genotype
Chong, B., Hegde, M., Fawkner, M., Simonet, W. S., Cassinelli, H., Çöker, M., Kanis, J. А., Seidel, J., Tau, C., Tüysüz, B., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.12.2095 · Cited by 124 · see citing works
Self-citation
THE EPIDEMIOLOGY OF PAGET'S DISEASE OF BONE
BARKER, D. J. P. (1984) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072011 · Cited by 122 · see citing works
Morbilliviruses and human disease
Rima, B. K., & Duprex, W. P. (2005) · The Journal of Pathology · doi:10.1002/path.1873 · Cited by 120 · see citing works
Detection of canine distemper virus in 100% of Paget’s disease samples by in situ-reverse transcriptase-polymerase chain reaction
MEE, A. P., DIXON, J., Hoyland, J. A., et al. (1998) · Bone · doi:10.1016/s8756-3282(98)00079-9 · Cited by 118 · see citing works
Contributions of the Measles Virus Nucleocapsid Gene and the SQSTM1/p62P392L Mutation to Paget's Disease
Kurihara, N., Hiruma, Y., Yamana, K., Michou, L., Rousseau, C., Morissette, J., Galson, D. L., Teramachi, J., Zhou, H., Dempster, D. W., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.002 · Cited by 117 · see citing works
Clinical Presentation of Paget’s Disease: Evaluation of a Contemporary Cohort and Systematic Review
Tan, A., & Ralston, S. H. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9904-1 · Cited by 115 · see citing works
Multisystem proteinopathy
Taylor, J. P. (2015) · Neurology · doi:10.1212/wnl.0000000000001862 · Cited by 111 · see citing works
Evidence for a Novel Osteosarcoma Tumor-Suppressor Gene in the Chromosome 18 Region Genetically Linked with Paget Disease of Bone
Nellissery, M. J., Padalecki, S. S., Brkanac, Z., Singer, F. R., Roodman, G. D., Unni, K. K., Leach, R. J., & Hansen, M. F. (1998) · The American Journal of Human Genetics · doi:10.1086/302019 · Cited by 110 · see citing works
Sequence Analysis of Measles Virus Nucleocapsid Transcripts in Patients with Paget's Disease
Friedrichs, W. E., Reddy, S. V., Bruder, J., Cundy, T., Cornish, J., Singer, F. R., & Roodman, G. D. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.145 · Cited by 110 · see citing works
Self-citation
Comparative responses of bone turnover markers to bisphosphonate therapy in Paget's disease of bone
Reid, I. R., Davidson, J. S., Wattie, D. J., et al. (2004) · Bone · doi:10.1016/j.bone.2004.03.023 · Cited by 110 · see citing works
Osteoclast differentiation from circulating mononuclear precursors in Paget’s disease is hypersensitive to 1,25-dihydroxyvitamin D3 and RANKL
Neale, S. D., Smith, R., Wass, J. A. H., & Athanasou, N. A. (2000) · Bone · doi:10.1016/s8756-3282(00)00345-8 · Cited by 110 · see citing works
Bone marrow mononuclear cells from patients with Paget's disease contain measles virus nucleocapsid messenger ribonucleic acid that has mutations in a specific region of the sequence.
Reddy, S. V., Singer, F. R., & Roodman, G. D. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.7.7608263 · Cited by 110 · see citing works
Paget?s Disease of Bone in New Zealand: Continued Decline in Disease Severity
Cundy, H., Gamble, G. D., Wattie, D. J., Rutland, M. D., & Cundy, T. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0281-z · Cited by 105 · see citing works
Self-citation
Familial Paget's disease in The Netherlands: Occurrence, identification of new mutations in the sequestosome 1 gene, and their clinical associations
Eekhoff, E. M. W., Karperien, M., Houtsma, D., Zwinderman, A. H., Dragoiescu, C., Kneppers, A. L. J., & Papapoulos, S. E. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20224 · Cited by 103 · see citing works
1,25-Dihydroxyvitamin D3 Hypersensitivity of Osteoclast Precursors from Patients with Paget's Disease
Menaa, C., Bársony, J., Reddy, S. V., Cornish, J., Cundy, T., & Roodman, G. D. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.2.228 · Cited by 98 · see citing works
Self-citation
A Novel Mutation (K378X) in the Sequestosome 1 Gene Associated With Increased NF-κB Signaling and Paget's Disease of Bone With a Severe Phenotype
Rea, S. L., Walsh, J. P., Ward, L., Yip, K. H. M., Ward, B. K., Kent, G. N., Steer, J. H., Xu, J., & Ratajczak, T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060405 · Cited by 93 · see citing works
Two Novel Mutations at Exon 8 of the Sequestosome 1 (SQSTM1) Gene in an Italian Series of Patients Affected by Paget's Disease of Bone (PDB)
Falchetti, A., Di Stefano, M., Marini, F., Del Monte, F., Mavilia, C., Strigoli, D., De Feo, M. L., Isaia, G., Masi, L., Amedei, A., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040203 · Cited by 87 · see citing works
Differential Gene Expression in Cultured Osteoblasts and Bone Marrow Stromal Cells From Patients With Paget's Disease of Bone
Naot, D., Bava, U., Matthews, B. G., Callon, K. E., Gamble, G. D., Black, M. A., Song, S., PITTO, R. P., Cundy, T., Cornish, J., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061108 · Cited by 87 · see citing works
Self-citation
ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor
Divisato, G., Formicola, D., Esposito, T., Merlotti, D., Pazzaglia, L., Fattore, A. D., Siris, E. S., Orcel, P., Brown, J. P., Nuti, R., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.12.016 · Cited by 86 · see citing works
Analysis of Environmental Factors in Familial Versus Sporadic Paget's Disease of Bone—The New England Registry for Paget's Disease of Bone
Seton, M., Choi, H. K., Hansen, M. F., Sebaldt, R. J., & Cooper, C. C. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.8.1519 · Cited by 82 · see citing works
Delayed Development of Paget's Disease in Offspring Inheriting SQSTM1 Mutations
Bolland, M. J., Tong, P. C., Naot, D., Callon, K. E., Wattie, D. J., Gamble, G. D., & Cundy, T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061204 · Cited by 82 · see citing works
Self-citation
PAST PETS AND PAGET'S DISEASE
O'Driscoll, J. B., & Anderson, D. C. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90852-9 · Cited by 81 · see citing works
Paget's Disease of Bone in the French Population: Novel SQSTM1 Mutations, Functional Analysis, and Genotype–Phenotype Correlations
Collet, C., Michou, L., Audran, M., Chasseigneaux, S., Hilliquin, P., Bardin, T., Lemaire, I., Cornélis, F., Launay, J., Orcel, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061106 · Cited by 78 · see citing works
Sarcoma arising in Paget's disease of bone: Declining incidence and increasing age at presentation
Mangham, D. C., Davie, M. W. J., & Grimer, R. J. (2008) · Bone · doi:10.1016/j.bone.2008.11.002 · Cited by 78 · see citing works
SQSTM1 gene analysis and gene-environment interaction in Paget's disease of bone
Gennari, L., Gianfrancesco, F., Stefano, M. D., Rendina, D., Merlotti, D., Esposito, T., Gallone, S., Fusco, P., Rainero, I., Fenoglio, P., et al. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.31 · Cited by 77 · see citing works
p62 Ubiquitin Binding-Associated Domain Mediated the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Formation
Yip, K. H. M., Feng, H., Pavlos, N. J., Zheng, M., & Xu, J. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050960 · Cited by 75 · see citing works
Multicenter Blinded Analysis of RT-PCR Detection Methods for Paramyxoviruses in Relation to Paget's Disease of Bone
Ralston, S. H., Afzal, M. A., Helfrich, M., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070103 · Cited by 73 · see citing works
Characteristics and Familial Aggregation of Paget's Disease of Bone in Italy
Merlotti, D., Gennari, L., Galli, B., Martini, G., Calabrò, A. R., Paola, V. D., Ceccarelli, E., Nardi, P., Avanzati, A., & Nuti, R. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050322 · Cited by 73 · see citing works
Cattle, Pets, and Pagetʼs Disease of Bone
López‐Abente, G., Morales-Piga, A. A., Elena-Ibáñez, Á., et al. (1997) · Epidemiology · doi:10.1097/00001648-199705000-00004 · Cited by 72 · see citing works
Osteoclasts Formed by Measles Virus-Infected Osteoclast Precursors from hCD46 Transgenic Mice Express Characteristics of Pagetic Osteoclasts*
Reddy, S. V., Kurihara, N., Menaa, C., et al. (2001) · Endocrinology · doi:10.1210/endo.142.7.8255 · Cited by 71 · see citing works
Paget's Disease of Bone in Italy
Gennari, L., Merlotti, D., Martini, G., & Nuti, R. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.06s203 · Cited by 71 · see citing works
Evidence for Increased Clinical Severity of Familial and Sporadic Paget's Disease of Bone in Campania, Southern Italy
Rendina, D., Gennari, L., FILIPPO, G. D., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060822 · Cited by 68 · see citing works
Absence of measles virus and canine distemper virus transcripts in long-term bone marrow cultures from patients with Paget’s disease of bone
Ooi, C. G., Walsh, C. A., Gallagher, J. A., et al. (2000) · Bone · doi:10.1016/s8756-3282(00)00343-4 · Cited by 68 · see citing works
Serum osteoprotegerin and its ligand in Paget’s disease of bone: relationship to disease activity and effect of treatment with bisphosphonates.
Alvarez, L., Peris, P., Guañabens, N., Vidal, S., Ros, I., Pons, F., Filella, X., Monegal, A., Muñoz‐Gomez, J., & Ballesta, A. M. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10834 · Cited by 66 · see citing works
Long‐Term Randomized Trial of Intensive Versus Symptomatic Management in Paget's Disease of Bone: The PRISM‐EZ Study
Tan, A., Goodman, K., Walker, A., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3066 · Cited by 65 · see citing works
Additional Cases of Osteitis Deformans
Paget, J. T.-E. H. (1882) · Journal of the Royal Society of Medicine · doi:10.1177/095952878206500120 · Cited by 64 · see citing works
Archaeological skeletons support a northwest European origin for Paget's disease of bone
Mays, S. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.64 · Cited by 63 · see citing works
Sequestosome-1 (SQSTM1) sequence variants in ALS cases in the UK: prevalence and coexistence of SQSTM1 mutations in ALS kindred with PDB
Kwok, C. T., Morris, A. G., & de Belleroche, J. (2013) · European Journal of Human Genetics · doi:10.1038/ejhg.2013.184 · Cited by 63 · see citing works
Osteoclasts in human osteopetrosis contain viral-nucleocapsid-like nuclear inclusions
Mills, B. G., Yabe, H., & Singer, F. R. (1988) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650030115 · Cited by 62 · see citing works
Sequestosome 1 Mutations in Paget's Disease of Bone in Australia: Prevalence, Genotype/Phenotype Correlation, and a Novel Non-UBA Domain Mutation (P364S) Associated With Increased NF-κB Signaling Without Loss of Ubiquitin Binding
Rea, S. L., Walsh, J. P., Ward, L., Magno, A. L., Ward, B. K., Shaw, B., Layfield, R., Kent, G. N., Xu, J., & Ratajczak, T. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090214 · Cited by 60 · see citing works
Identification of Sex-Specific Associations Between Polymorphisms of the Osteoprotegerin Gene, TNFRSF11B, and Paget's Disease of Bone
Beyens, G., Daroszewska, A., de Freitas, F., Fransén, E., Vanhoenacker, F. M. H. M., Verbruggen, L., Zmierczak, H., Westhovens, R., Offel, J. V., Ralston, S. H., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070333 · Cited by 59 · see citing works
Absence of detectable measles virus genome sequence in blood of autistic children who have had their MMR vaccination during the routine childhood immunization schedule of UK
Afzal, M. A., Ozoemena, L. C., O'Hare, A. E., Kidger, K. A., Bentley, M. L., & Minor, P. D. (2006) · Journal of Medical Virology · doi:10.1002/jmv.20585 · Cited by 59 · see citing works
Paget disease of bone
Cundy, T., & Bolland, M. J. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.06.001 · Cited by 58 · see citing works
Self-citation
Common susceptibility alleles and SQSTM1 mutations predict disease extent and severity in a multinational study of patients with Paget's disease
Albagha, O., Visconti, M. R., Alonso, N., Wani, S., Goodman, K., Fraser, W. D., Gennari, L., Merlotti, D., Gianfrancesco, F., Esposito, T., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1975 · Cited by 56 · see citing works
Clinical Characteristics and Evolution of Giant Cell Tumor Occurring in Paget's Disease of Bone
Rendina, D., FILIPPO, G. D., Ralston, S. H., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2349 · Cited by 55 · see citing works
Evidence for p62 aggregate formation: Role in cell survival
Paine, M. G., Babu, J. R., Seibenhener, M. L., & Wooten, M. W. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.08.010 · Cited by 55 · see citing works
Polymorphisms in Autophagy Genes Are Associated with Paget Disease of Bone
Usategui‐Martín, R., García‐Aparicio, J., Corral-Gudino, L., Calero‐Paniagua, I., del Pino‐Montes, J., & González‐Sarmiento, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128984 · Cited by 54 · see citing works
Somatic Mutations in SQSTM1 Detected in Affected Tissues From Patients With Sporadic Paget's Disease of Bone
Merchant, A. S., Smielewska, M., Patel, N., Akunowicz, J., Saria, E. A., Delaney, J. D., Leach, R. J., Seton, M., & Hansen, M. F. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081105 · Cited by 54 · see citing works
Role of TAFII-17, a VDR Binding Protein, in the Increased Osteoclast Formation in Paget's Disease
Kurihara, N., Reddy, S. V., Araki, N., Ishizuka, S., Ozono, K., Cornish, J., Cundy, T., Singer, F. R., & Roodman, G. D. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040312 · Cited by 54 · see citing works
Self-citation
Paget's disease: Acquired resistance to one aminobisphosphonate with retained response to another
Gutteridge, D. H., Ward, L., Stewart, G. O., et al. (1999) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650140216 · Cited by 51 · see citing works
Ubiquitin-Associated Domain Mutations of SQSTM1 in Paget's Disease of Bone: Evidence for a Founder Effect in Patients of British Descent
Lucas, G., Hocking, L. J., Daroszewska, A., Cundy, T., Nicholson, G. C., Walsh, J. P., Fraser, W. D., Meier, C., Hooper, M. J., & Ralston, S. H. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041106 · Cited by 51 · see citing works
Self-citation
Paget's disease of bone--becoming a rarity?
Bastin, S., Bird, H., Gamble, G. D., & Cundy, T. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/kep212 · Cited by 50 · see citing works
Self-citation
Characterization of a Non-UBA Domain Missense Mutation of Sequestosome 1 (SQSTM1) in Paget's Disease of Bone
Najat, D., Garner, T. P., Hagen, T., Shaw, B., Sheppard, P. W., Falchetti, A., Marini, F., Brandi, M. L., Long, J., Cavey, J. R., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081204 · Cited by 50 · see citing works
Identification of a Major Locus for Paget's Disease on Chromosome 10p13 in Families of British Descent
Lucas, G., Riches, P. L., Hocking, L. J., Cundy, T., Nicholson, G. C., Walsh, J. P., & Ralston, S. H. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.071004 · Cited by 49 · see citing works
Self-citation
Pamidronate Treatment of the Neurologic Sequelae of Pagetic Spinal Stenosis
Wallace, E. R. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430160167017 · Cited by 48 · see citing works
Genetic Epidemiology of Paget’s Disease of Bone in Italy: sequestosome1/p62 Gene Mutational Test and Haplotype Analysis at 5q35 in a Large Representative Series of Sporadic and Familial Italian Cases of Paget’s Disease of Bone
On Behalf of the GenePage Project, Falchetti, A., Stefano, M. D., Marini, F., Ortolani, S., Ulivieri, F. M., Bergui, S., Masi, L., Cepollaro, C., Benucci, M., et al. (2008) · Calcified Tissue International · doi:10.1007/s00223-008-9192-8 · Cited by 48 · see citing works
Clinical and Genetic Advances in Paget’s Disease of Bone: a Review
Alonso, N., Calero‐Paniagua, I., & del Pino‐Montes, J. (2016) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-016-9226-0 · Cited by 48 · see citing works
Canine Distemper Virus Induces Human Osteoclastogenesis Through NF-κB and Sequestosome 1/P62 Activation
Selby, P. L., Davies, M., & MEE, A. P. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060805 · Cited by 47 · see citing works
Durability of Response to Zoledronate Treatment and Competing Mortality in Paget's Disease of Bone
Cundy, T., Maslowski, K., Grey, A. B., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3029 · Cited by 44 · see citing works
Self-citation
Founder Effect in Different European Countries for the Recurrent P392L SQSTM1 Mutation in Paget’s Disease of Bone
Chung, P. Y. J., Beyens, G., Guañabens, N., Boonen, S., Papapoulos, S. E., Karperien, M., Eekhoff, E. M. W., Wesenbeeck, L. V., Jennes, K., Geusens, P., et al. (2008) · Calcified Tissue International · doi:10.1007/s00223-008-9137-2 · Cited by 40 · see citing works
Evaluation of the role of Valosin-containing protein in the pathogenesis of familial and sporadic Paget's disease of bone
Lucas, G., Mehta, S. G., Hocking, L. J., Stewart, T. L., Cundy, T., Nicholson, G. C., Walsh, J. P., Fraser, W. D., Watts, G. D. J., Ralston, S. H., et al. (2005) · Bone · doi:10.1016/j.bone.2005.07.014 · Cited by 39 · see citing works
Self-citation
Mortality from Malignant Tumours of Bone and Paget's Disease in the United States and in England and Wales
GARDNER, M. J., & BARKER, D. J. P. (1978) · International Journal of Epidemiology · doi:10.1093/ije/7.2.121 · Cited by 37 · see citing works
Epidemiogenetic study of French families with Paget's disease of bone
Michou, L., Collet, C., Morissette, J., Audran, M., Thomas, T., Gagnon, É., Launay, J., Laplanche, J., Brown, J. P., & Orcel, P. (2011) · Joint Bone Spine · doi:10.1016/j.jbspin.2011.07.005 · Cited by 36 · see citing works
Effect of age and gender on the number and distribution of sites in Paget's disease of bone
Haddaway, M. J., Davie, M. W. J., McCall, I. W., et al. (2007) · British Journal of Radiology · doi:10.1259/bjr/84718521 · Cited by 36 · see citing works
Progression in length and width of pagetic lesions, and estimation of age at disease onset.
Rénier, J. C., & Audran, M. (1997) · PubMed · Cited by 35 · see citing works
Interleukin-6 and osteoprotegerin systems in Paget’s disease of bone: relationship to risedronate treatment.
Mossetti, G., Rendina, D., De Filippo, G., Viceconti, R., Di Domenico, G., Cioffi, M., Postiglione, L., & Nunziata, V. (2005) · Bone · doi:10.1016/j.bone.2004.11.004 · Cited by 35 · see citing works
Paget's Disease of Bone and Previous Pet Ownership in the United States: Dogs Exonerated
Siris, E. S., Kelsey, J. L., Flaster, E. R., et al. (1990) · International Journal of Epidemiology · doi:10.1093/ije/19.2.455 · Cited by 35 · see citing works
Paget's disease of bone in South Africa
Guyer, P. B., & Chamberlain, A. T. (1988) · Clinical Radiology · doi:10.1016/s0009-9260(88)80341-6 · Cited by 35 · see citing works
Cementless Hip Arthroplasty in Paget's Disease at Medium-Term Follow-Up (Average of 6.7 Years)
Lusty, P. J., Walter, W. L., Walter, W. K., et al. (2007) · The Journal of Arthroplasty · doi:10.1016/j.arth.2006.09.010 · Cited by 34 · see citing works
Familial Early-Onset Paget’s Disease of Bone Associated with a Novel hnRNPA2B1 Mutation
Qi, X., Pang, Q., Wang, J., Zhao, Z., Wang, O., Xu, L., Mao, J., Jiang, Y., Li, M., Xing, X., et al. (2017) · Calcified Tissue International · doi:10.1007/s00223-017-0269-0 · Cited by 34 · see citing works
The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation
Song, C., Xiao, Z., Nagashima, K., Li, C.-C. H., Lockett, S., Dai, R., Cho, E. H., Conrads, T. P., Veenstra, T. D., Colburn, N. H., et al. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.12.026 · Cited by 33 · see citing works
Bone stromal cells in pagetic bone and Paget's sarcoma express RANKL and support human osteoclast formation
Sun, S., Lau, Y., Itonaga, I., et al. (2006) · The Journal of Pathology · doi:10.1002/path.1953 · Cited by 31 · see citing works
Absence of Somatic SQSTM1 Mutations in Paget’s Disease of Bone
Matthews, B. G., Naot, D., Bava, U., Callon, K. E., PITTO, R. P., McCowan, S. A., Wattie, D. J., Cundy, T., Cornish, J., & Reid, I. R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1140 · Cited by 30 · see citing works
Self-citation
Evolution of Paget's disease of bone in adults inheriting SQSTM 1 mutations
Cundy, T., Rutland, M. D., Naot, D., & Bolland, M. J. (2015) · Clinical Endocrinology · doi:10.1111/cen.12741 · Cited by 30 · see citing works
Self-citation
Environmental factors associated with familial or non-familial forms of Paget's disease of bone
Audet, M.-C., Jean, S., Beaudoin, C., Guay-Bélanger, S., Dumont, J., Brown, J. P., & Michou, L. (2016) · Joint Bone Spine · doi:10.1016/j.jbspin.2016.11.010 · Cited by 30 · see citing works
Clinical and Cellular Phenotypes Associated With Sequestosome 1 (SQSTM1) Mutations
Leach, R. J., Singer, F. R., Ench, Y., Wisdom, J. H., Pina, D. S., & Johnson‐Pais, T. L. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.06s208 · Cited by 29 · see citing works
Paget's disease in patients of Asian descent in New Zealand
Sankaran, S., Naot, D., Grey, A. B., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.507 · Cited by 28 · see citing works
Identification of possible areas of high prevalence of Paget's disease of bone in Spain.
López‐Abente, G., Morales-Piga, A. A., Bachiller‐Corral, J., et al. (2004) · PubMed · Cited by 27 · see citing works
Paget's osteosarcoma and post-radiation osteosarcoma: secondary osteosarcoma at Middlemore Hospital, New Zealand
Dray, M. S., & Miller, M. V. (2008) · Pathology · doi:10.1080/00313020802320663 · Cited by 26 · see citing works
Gene Expression Profiling in Paget's Disease of Bone: Upregulation of Interferon Signaling Pathways in Pagetic Monocytes and Lymphocytes
Nagy, Z. B., Gergely, P., Donáth, J., Borgulya, G., Csanád, M., & Poór, G. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.071021 · Cited by 22 · see citing works
Identification and Molecular Characterization of a Novel Splice-Site Mutation (G1205C) in the SQSTM1 Gene Causing Paget’s Disease of Bone in an Extended American Family
Beyens, G., Wuyts, W. A., Cleiren, E., de Freitas, F., Tiegs, R. D., & Hul, W. V. (2006) · Calcified Tissue International · doi:10.1007/s00223-006-0122-3 · Cited by 22 · see citing works
Upregulation of Epstein-Barr virus-encoded latent membrane protein by human herpesvirus 6 superinfection of EBV-carrying Burkitt lymphoma cells
Cuomo, L., Trivedi, P., de Grazia, U., Calogero, A., D’Onofrio, M., Yang, W., Frati, L., Faggioni, A., Rymo, L., & Ragona, G. (1998) · Journal of Medical Virology · doi:10.1002/(sici)1096-9071(199807)55:3 · Cited by 19 · see citing works
The radiology of excavated Saxon and medieval human remains from winchester
Price, J. L. (1975) · Clinical Radiology · doi:10.1016/s0009-9260(75)80080-8 · Cited by 18 · see citing works
Paget's disease of bone among British migrants to Australia.
Gardner, M. J., Guyer, P. B., & BARKER, D. J. P. (1978) · BMJ · doi:10.1136/bmj.2.6149.1436-d · Cited by 15 · see citing works
Familial Paget Disease and SQSTM1 Mutations in New Zealand
Cundy, T., Naot, D., Bava, U., et al. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9514-0 · Cited by 14 · see citing works
Self-citation
TRANSFER OF PAGETʼS DISEASE FROM ONE PART OF THE SKELETON TO ANOTHER AS A RESULT OF AUTOGENOUS BONE-GRAFTING
Hamadouche, M., MATHIEU, M., Topouchian, V., et al. (2002) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200211000-00023 · Cited by 14 · see citing works
Paget’s disease of bone
Matthews, B. G., & Cundy, T. (2009) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.43 · Cited by 7 · see citing works
Self-citation
Advances in Pathobiology and Management of Paget's Disease of Bone
(2016) · Elsevier eBooks · doi:10.1016/c2015-0-02298-5 · Cited by 6 · see citing works
Treatment of Paget’s Disease of Bone
Reid, I. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-805083-5.00009-9 · Cited by 4 · see citing works

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Authors: Cundy, T.
Affiliations: University of Auckland (NZ)
Corresponding author: Cundy, Tim
ORCID: Cundy, Tim
Venue: Metabolism
Publisher: Elsevier BV
Published: 2018-03
Volume: 80
Pages: 5-14
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2017.06.010
OpenAlex: W2727993130
Cited by: 76
References: 132
Citations by year: 2026: 8 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 8 · 2020: 11 · 2019: 13 · 2018: 3 · 2017: 3 · 2014: 1 · 2013: 1
FWCI: 0.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Oncology › Bone health and treatments
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: Paget's disease of bone, high-turnover bone disease, natural history (disease), genetic susceptibility, environmental risk factors, bisphosphonates, treatment, diagnosis, age at presentation, bone involvement
MeSH terms: Aged, Aged, 80 and over, Diphosphonates, Female, Humans, Male, Middle Aged, Osteitis Deformans, Prevalence, Bone Remodeling, Genetic Predisposition to Disease, Bone Density Conservation Agents

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