The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Antitubular Basement-Membrane Antibodies in Methicillin-Associated Interstitial Nephritis
Abstract
Abstract Antitubular basement-membrane antibodies were detected by indirect immunofluorescence in the serum of a patient in whom severe renal failure developed while he was receiving methicillin. A renal biopsy showed a severe mononuclear interstitial infiltrate with focal areas of tubular degeneration. IgG, C3 and a methicillin antigen assumed to be dimethoxyphenylpenicilloyl were present in a linear pattern along the tubular basement membrane but not along the glomerular basement membrane. The dimethoxyphenylpenicilloyl-tubular-basement-membrane hapten protein conjugate apparently led to an immune response with antitubular basement-membrane antibodies being involved in the immunopathogenesis of the patient's interstitial nephritis. (N Engl J Med 291:381–384, 1974)
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In the citing paper
“Immunofluorescence microscopy is typically negative in patients with AIN, although a very few cases of methicillin-induced AIN with tubular basement membrane deposits of immunoglobulin have been reported [73].”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [73]
In the citing paper
“Immune complex deposits are relatively uncommon in drug-induced AIN—they have been reported with drugs such as methicillin and rifampin [73–75], which exhibit linear or granular staining for immunoglobulin G and C3 on tubular basement membrane (anti–tubular basement membrane antibodies).”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [73]
In the citing paper
“Eosinophiluria cannot be used in diagnosing AIN because it is detected in many renal and nonrenal diseases such as pyelonephritis, cystitis, prostatitis, atheroembolic disease, acute tubular nephritis, rapidly progressive glomerulonephritis and bladder malignancies, among others [50, 73, 90, 91].”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [73]
Citations
Cites
Lerner, R. A., Glassock, R. J., & Dixon, F. J. (1967) · The Journal of Experimental Medicine · doi:10.1084/jem.126.6.989 · Cited by 730
Anti-glomerular basement membrane antibody-induced glomerulonephritis
Wilson, C. B., & Dixon, F. J. (1973) · Kidney International · doi:10.1038/ki.1973.14 · Cited by 507
Self-citationRenal Failure and Interstitial Nephritis Due to Penicillin and Methicillin
Baldwin, D. S., Levine, B. B., McCluskey, R. T., & Gallo, G. R. (1968) · New England Journal of Medicine · doi:10.1056/nejm196812052792302 · Cited by 340
Levine, B. B. (1966) · New England Journal of Medicine · doi:10.1056/nejm196611172752009 · Cited by 262
Renal Tubular Disease and Autoantibodies against Tubular Basement Membrane Induced in Guinea Pigs
Steblay, R. W., & Rudofsky, U. H. (1971) · The Journal of Immunology · doi:10.4049/jimmunol.107.2.589 · Cited by 122
Immunopathologic study of an autoimmune tubular and interstitial renal disease in brown Norway rats.
Sugisaki, T., Klassen, J., Milgrom, F., Andres, G. A., & Rt, M. (1973) · PubMed · Cited by 105
Weigle, W. O. (1965) · The Journal of Experimental Medicine · doi:10.1084/jem.122.6.1049 · Cited by 82
Levine, B. B., FELLNER, M. J., & Levytska, V. (1966) · PubMed · Cited by 81
Immunologically Mediated Glomerular, Tubular and Interstitial Renal Disease
Steinmetz, P. R., Balko, C., McCluskey, R. T., et al. (1973) · New England Journal of Medicine · doi:10.1056/nejm197303152881108 · Cited by 80
Tubular Lesions Produced by Autoantibodies to Tubular Basement Membrane in Human Renal Allografts
Klassen, J., Kano, K., Milgrom, F., Menno, A. B., ANTHONE, S., Anthone, R., Sepulveda, M., Elwood, C. M., & Andres, G. A. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000231067 · Cited by 65
Research works printed but not linked: 4
- Gilbert, 1970, Ann Allergy, 28, 378
- Sugisaki, 1973, Lab Invest, 28, 658
- Weinstein L: Penicillin, The Pharmacological Basis of Therapeutics. Third edition. Edited by LS Goodman, A Gilman. New York, The Macmillan Company, 1965, pp 1193–1229
- Eisen HN: Antibody-antigen reactions, Microbiology. Second edition. Edited by BD Davis, R Dulbecco, HN Eisen, et al. Hagerstown, Maryland, Harper and Row, 1973, pp 359–404
Cited by
Drug-induced acute interstitial nephritis
Perazella, M. A., & Markowitz, G. S. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.71 · Cited by 378
Involvement of Drug-Specific T Cells in Acute Drug-Induced Interstitial Nephritis
Spanou, Z., Keller, M., Britschgi, M., Yawalkar, N., Fehr, T., Neuweiler, J., Gugger, M., Mohaupt, M., & Pichler, W. J. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006050418 · Cited by 151
Drug-Induced Acute Interstitial Nephritis
Moledina, D. G., & Perazella, M. A. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07630717 · Cited by 133
Mechanisms of Drug-Induced Interstitial Nephritis
Raghavan, R., & Shawar, S. (2017) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2016.11.004 · Cited by 117
Review: Acute tubulointerstitial nephritis
Toto, R. D. (1990) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199006000-00007 · Cited by 94
Metadata
- Authors
- Border, W. A., Lehman, D. H., Egan, J. D., Sass, H. J., Glode, J. E., & Wilson, C. B.
- Affiliations
- Creighton University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1974-08-22
- Volume
- 291
- Issue
- 8
- Pages
- 381-384
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2332571552
- Cited by
- 246
- References
- 17
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 4 · 2020: 1 · 2019: 2 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 17.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Keywords
- drug-induced nephrotoxicity, methicillin, tubular basement membrane, immunopathogenesis, renal failure, tubular degeneration, C3 deposition
- MeSH terms
- Adult, Animals, Haplorhini, Antigens, Autoantibodies, Basement Membrane, Biopsy, Complement System Proteins, Drug Hypersensitivity, Fluorescent Antibody Technique, Haptens, Humans, Immunoglobulin G, Immune Sera, Kidney, Kidney Glomerulus, Kidney Tubules, Male, Methicillin, Nephritis, Interstitial, Protein Binding, Rabbits
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- CoChat. (2026). Citation check: Antitubular Basement-Membrane Antibodies in Methicillin-Associated Interstitial Nephritis. https://app.cochat.ai/papers/10.1056/nejm197408222910803
- The paper
- Border, W. A., Lehman, D. H., Egan, J. D., Sass, H. J., Glode, J. E., & Wilson, C. B. (1974). Antitubular Basement-Membrane Antibodies in Methicillin-Associated Interstitial Nephritis. New England Journal of Medicine. https://doi.org/10.1056/nejm197408222910803
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.