The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Inhibition of Granulocyte Adherence by Ethanol, Prednisone, and Aspirin, Measured with an Assay System
Abstract
A simple, rapid, in vitro assay was developed to study granulocyte adherence, an important component of the inflammatory reaction. Heparinized whole blood is filtered through nylon fiber packed in Pasteur pipettes, and the percentage of granulocytes adhering is calculated. Test variability from morning to evening, before and after meals, and on successive days is less than 10 per cent. In vitro exposure of whole blood to ethanol concentrations varying from 100 to 1000 mg per 100 ml caused a dose-dependent, significant inhibition of adherence (16–87 per cent, p<0.05), but incubation with sodium salicylate (5 to 50 mg per 100 ml) or hydrocortisone sodium succinate (500 to 3000 μg per 100 ml) had no effect. In all volunteers receiving 40 mg of prednisone or 1.2 g of aspirin, impaired adherence developed, suggesting that glucocorticoids and salicylates may affect adherence in vivo by inducing an inhibitor. The anti-inflammatory effect of salicylates, hydrocortisone and ethanol may be secondary to their inhibition of granulocyte adherence. (N Engl J Med 291:642–646, 1974)
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The pharmacological basis of therapeutics
Starr, I. (1941) · American Heart Journal · doi:10.1016/s0002-8703(41)90958-4 · Cited by 1,902
ELECTRON MICROGRAPHIC OBSERVATIONS ON THE EMIGRATION OF LEUCOCYTES
Marchesi, V. T., & Florey, H. W. (1960) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1960.sp001489 · Cited by 411
Miller, M., Oski, F., & Harris, M. (1971) · The Lancet · doi:10.1016/s0140-6736(71)92679-1 · Cited by 238
Chemotactic Function in the Human Neonate: Humoral and Cellular Aspects
Miller, M. E. (1971) · Pediatric Research · doi:10.1203/00006450-197109000-00007 · Cited by 192
Page, A. R. (1957) · A M A Journal of Diseases of Children · doi:10.1001/archpedi.1957.04030070035006 · Cited by 118
The use of 51-chromium in the study of leukocyte kinetics in chronic myelocytic leukemia.
Cp, D., & Perry, S. (1968) · PubMed · Cited by 40
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Glucocorticosteroid Therapy: Mechanisms of Action and Clinical Considerations
FAUCI, A. S., DALE, D. C., & BALOW, J. E. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-3-304 · Cited by 1,044
McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
Vitamin E ingestion improves several immune functions in elderly men and women
De la Fuente, M., Hernanz, A., Guayerbas, N., Manuel Victor, V., & Arnalich, F. (2008) · Free Radical Research · doi:10.1080/10715760801898838 · Cited by 124
Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults
Alonso‐Fernández, P., Puerto, M., Maté, I., Ribera, J. M., & De La Fuente, M. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02018.x · Cited by 100
Metadata
- Authors
- MacGregor, R. R., Spagnuolo, P. J., & Lentnek, A. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1974-09-26
- Volume
- 291
- Issue
- 13
- Pages
- 642-646
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2328047889
- Cited by
- 486
- References
- 6
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- MacGregor, R. R., Spagnuolo, P. J., & Lentnek, A. L. (1974). Inhibition of Granulocyte Adherence by Ethanol, Prednisone, and Aspirin, Measured with an Assay System. New England Journal of Medicine. https://doi.org/10.1056/nejm197409262911302
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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