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Cited by 264

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Effects of Corticosteroid Therapy on Human Monocyte Function

Rinehart, John J., Sagone, Arthur L., Balcerzak, Stanley P., Ackerman, G. Adolph, LoBuglio, Albert F.·1975·New England Journal of Medicine
DOI 10.1056/nejm197501302920504
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Abstract

Since high-dose corticosteroid therapy appears to impair cellular defense mechanisms, this study examined its effect on human monocyte function. Fifteen normal volunteers were studied before and after a three-day course of prednisone therapy (50 mg every 12 hours for six doses). A transient period of monocytopenia occurred during the first few hours of therapy. Monocyte killing of Staphylococcus aureus was reduced in nine subjects from 5.6 plus or minus 0.2 (plus or minus S.E.) X 10-6 organisms before to 1.3 plus or minus 0.4 x 10-6 organisms at completion of therapy (p less than 0.01). Similary, killing of Candida tropicalis four subjects fell from 9.3 plus or minus 0.6 to 0.6 plus or minus 0.3 x 10-6 organisma (p less than 0.01). Bactericidal activity returned to normal levels 48 hours after the last dose of prednisone. These same monocyte preparations had normal or increased chemotactic response, phagocytic rate of cryptococci, hexosemonophosphate-shunt response to phagocytosis and ultrastructural characteristics. This impairment of bactericidal and fungicidal activity during prednisone therapy may contribute to the infectious complications seen in patients receiving comparable doses of corticosteroids.

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Metadata

Authors
Rinehart, J. J., Sagone, A. L., Balcerzak, S. P., Ackerman, G. A., & LoBuglio, A. F.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1975-01-30
Volume
292
Issue
5
Pages
236-241
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm197501302920504
OpenAlex
W2340567530
Cited by
264
References
17
FWCI
11.68
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Effects of Corticosteroid Therapy on Human Monocyte Function. https://app.cochat.ai/papers/10.1056/nejm197501302920504
The paper
Rinehart, J. J., Sagone, A. L., Balcerzak, S. P., Ackerman, G. A., & LoBuglio, A. F. (1975). Effects of Corticosteroid Therapy on Human Monocyte Function. New England Journal of Medicine. https://doi.org/10.1056/nejm197501302920504

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.