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Ferritin in Serum: Clinical and Biochemical Implications
Abstract
FERRITIN is the major iron storage protein in the body. Although it is found in all tissues there is little quantitative information about its distribution. Measurements of non-heme iron concentrations indicate a particularly large amount in the liver, spleen and bone marrow. Each ferritin molecule is thought to consist of a spherical protein shell of molecular weight about 450,000 made up of 24 subunits with a variable amount of iron as a crystalline core of ferric-oxide-phosphate. The study of tissue ferritins has shown that each molecule may accumulate up to about 4000 atoms of iron, and the fully saturated protein . . .
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Cited by
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
Weinberg, E. D. (1978) · Microbiological Reviews · doi:10.1128/mmbr.42.1.45-66.1978 · Cited by 1,254
Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122
IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK
Sullivan, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92463-6 · Cited by 969
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway
Cohen, L. A., Gutierrez, L., Weiss, A., Leichtmann-Bardoogo, Y., Zhang, D.-L., Crooks, D. R., Sougrat, R., Morgenstern, A., Galy, B., Hentze, M. W., et al. (2010) · Blood · doi:10.1182/blood-2009-11-253815 · Cited by 452
Metadata
- Authors
- Jacobs, A., & Worwood, M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1975-05
- Volume
- 292
- Issue
- 18
- Pages
- 951-956
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2056555426
- Cited by
- 352
- References
- 0
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- closed
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