The DOI matches its Crossref record.
Total Eosinophil Counts in the Management of Bronchial Asthma
Abstract
Total eosinophil counts were investigated in asthmatic patients to determine their usefulness in the diagnosis and management of steroid-dependent asthma. Counts averaged 122 plus or minus 74 (S.D.) per mm-3 (65 untreated normal subjects) and 43 plus or minus 22 per mm-3 (six prednisone-treated normal subjects). Fifty-two patients with active bronchial asthma showed significant eosinophilia (greater than 350/mm-3 off and greater than 85/mm-3 on steroids), suggesting that eosinophilia is an important diagnostic feature of bronchial asthma. In 14 patients (60 observations), the counts showed significant inverse correlation with specific airway conductance--r equals 0.74, p less than 0.001--and with a variety of other measurements of bronchial dynamics and lung volumes, suggesting that the total eosinophil count reflects asthmatic activity and is useful for regulating steroid dosage and for early detection of exacerbations.
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Citations
Cited by
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L.-P., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P. L., Gibson, P. G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-060st · Cited by 1,918
Weller, P. F., Lee, C. W., Foster, D. W., Corey, E. J., Austen, K. F., & Lewis, R. A. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.24.7626 · Cited by 476
Szefler, S. J., Wenzel, S., Brown, R., Erzurum, S. C., Fahy, J. V., Hamilton, R. G., Hunt, J. F., Kita, H., Liu, A. H., Panettieri, R. A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.979 · Cited by 395
Pharmacology of the Eosinophil
Giembycz, M. A., & Lindsay, M. A. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01404-2 · Cited by 351
Metadata
- Authors
- Horn, B. R., Robin, E. D., Theodore, J., & Van Kessel, A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1975-05-29
- Volume
- 292
- Issue
- 22
- Pages
- 1152-1155
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2323426201
- Cited by
- 393
- References
- 0
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Horn, B. R., Robin, E. D., Theodore, J., & Van Kessel, A. (1975). Total Eosinophil Counts in the Management of Bronchial Asthma. New England Journal of Medicine. https://doi.org/10.1056/nejm197505292922204
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
