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Estrogens and Endometrial Cancer in a Retirement Community
Abstract
All cases of endometrial cancer occurring among the residents of an affluent retirement community were compared with controls chosen from a roster of all women in the same community. Evidence of estrogen and other drug use and of selected medical conditions was obtained from three sources: medical records of the principal care facility, interviews, and the records of the local pharmacy. The risk ratio for any estrogen use was estimated from all available evidence to be 8.0 (95 per cent confidence interval, 3.5 to 18.1). and the for conjugated estrogen use to be 5.6 (95 per cent confidence interval, 2.8 to 11.1). Increased risk from estrogens was shown for invasive as well as noninvasive cancer, and a dose-response effect was demonstrated. For an estrogen user, the risk from endometrial cancer appeared to exceed by far the base-line risk from any other single cancer.
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Citations
Cited by
The Handbook of Research Synthesis and Meta-Analysis
(2019) · doi:10.7758/9781610448864 · Cited by 4,553
Hormone replacement therapy and endometrial cancer risk: A meta-analysis
GRADY, D., GEBRETSADIK, T., KERLIKOWSKE, K., ERNSTER, V, & PETITTI, D. (1995) · Obstetrics & Gynecology · doi:10.1016/0029-7844(94)00383-o · Cited by 962
Treatment of symptoms of the menopause: an Endocrine Society Clinical Practice Guideline
Stuenkel, C. A., Davis, S. R., Gompel, A., Lumsden, M. A., Murad, M. H., Pinkerton, J. V., & Santen, R. J. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2236 · Cited by 884
Weiderpass, E., Persson, I., Adami, H.-O., Magnusson, C., Lindgren, A., & Baron, J. A. (2000) · Cancer Causes & Control · doi:10.1023/a:1008946825313 · Cited by 273
Alternative Analytic Methods for Case-Control Studies of Estrogens and Endometrial Cancer
Horwitz, R. I., & Feinstein, A. R. (1978) · New England Journal of Medicine · doi:10.1056/nejm197811162992001 · Cited by 258
Metadata
- Authors
- Mack, T. M., Pike, M. C., Henderson, B. E., Pfeffer, R. I., Gerkins, V. R., Arthur, M., & Brown, S. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-06-03
- Volume
- 294
- Issue
- 23
- Pages
- 1262-1267
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2336212480
- Cited by
- 557
- References
- 0
- FWCI
- 41.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mack, T. M., Pike, M. C., Henderson, B. E., Pfeffer, R. I., Gerkins, V. R., Arthur, M., & Brown, S. E. (1976). Estrogens and Endometrial Cancer in a Retirement Community. New England Journal of Medicine. https://doi.org/10.1056/nejm197606032942304
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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