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Cited by 258

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Alternative Analytic Methods for Case-Control Studies of Estrogens and Endometrial Cancer

Horwitz, Ralph I., Feinstein, Alvan R.·1978·New England Journal of Medicine

Abstract

In a case-control study of estrogens and endometrial cancer, alternative sampling methods were used to eliminate the detection bias that arises from the increased diagnostic attention received by women with uterine bleeding after estrogen exposure. In a set of cases and controls chosen by conventional procedures the odds ratio was 11.98. In an alternative set of cases and controls at the same institution, consisting of patients who had all received dilatation and curettage or hysterectomy because of uterine bleeding, the odds ratio was 1.7. A methodologic analysis demonstrates detection bias arising from the pattern of hospital referral and shows the way in which the bias is neglected or increased by conventional sampling procedures, but reduced by the alternative procedure. The magnitude of the association between estrogens and endometrial cancer has been greatly overestimated because of detection bias; when an appropriate compensation for the bias is introduced, the odds ratio approaches a value much closer to 1.

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Citations

Cites

Show all 9 references

Research works printed but not linked: 5

  1. Gray, 1977, Obstet Gynecol, 49, 385
  2. Pacheco, 1968, Obstet Gynecol, 32, 40
  3. Hofmeister, 1964, Obstet Gynecol, 23, 386
  4. Abramson, 1966, Obstet Gynecol, 27, 381
  5. Ng, 1970, Obstet Gynecol, 35, 437

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Metadata

Authors
Horwitz, R. I., & Feinstein, A. R.
Venue
New England Journal of Medicine
Published
1978-11-16
Volume
299
Issue
20
Pages
1089-1094
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2314282709
Cited by
258
References
9
FWCI
27.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Alternative Analytic Methods for Case-Control Studies of Estrogens and Endometrial Cancer. https://app.cochat.ai/papers/10.1056/nejm197811162992001
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Horwitz, R. I., & Feinstein, A. R. (1978). Alternative Analytic Methods for Case-Control Studies of Estrogens and Endometrial Cancer. New England Journal of Medicine. https://doi.org/10.1056/nejm197811162992001

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.