The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Clinical Semi-Starvation: Depression of Hypoxic Ventilatory Response
Abstract
A decreased metabolic rate has been associated with decreased ventilatory response to hypoxia and hypercapnia, and also with starvation. We fed a 500-calorie carbohydrate diet with supplemental electrolytes, designed to simulate alimentation by usual intravenous fluids, to seven normal subjects for 10 days to determine the effect of semi-starvation on metabolic rate and ventilatory responses. By the 10th day metabolic rate was significantly decreased, and hypoxic ventilatory response decreased to 42% of control (P less than 0.05). In two subjects, hypoxic ventilatory response was virtually abolished at day 10. These changes reversed toward normal with refeeding. The decrease in hypoxic ventilatory response response was significantly (P less than 0.01) related to the decrease in metabolic rate. Hypercapnic ventilatory response, measured as the slope of the ventilatory response to hypercapnia, decreased slightly but not significantly. The decrease in hypoxic ventilatory response seen during semi-starvation may contribute to the hypoxemia and respiratory failure subsequent to caloric restriction.
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Citations
Cites
The Biology of Human Starvation: Volume I
KEYS, A., BROŽEK, J., HENSCHEL, A., MICKELSEN, O., & TAYLOR, H. L. (1950) · doi:10.5749/j.ctv9b2tqv · Cited by 2,039
Cited by
Nutritional status and mortality in chronic obstructive pulmonary disease.
Gray-Donald, K., Gibbons, L., Shapiro, S. H., Macklem, P. T., & Martin, J. G. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630580 · Cited by 398
Hypercapnic Ventilatory Response in Patients With and Without Obstructive Sleep Apnea
Sin, D. D., Jones, R. L., & Man, G. C. (2000) · Chest · doi:10.1378/chest.117.2.454 · Cited by 62
Metadata
- Authors
- Doekel, R. C., Zwillich, C. W., Scoggin, C. H., Kryger, M., & Weil, J. V.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-08-12
- Volume
- 295
- Issue
- 7
- Pages
- 358-361
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2036403205
- Cited by
- 224
- References
- 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clinical Semi-Starvation: Depression of Hypoxic Ventilatory Response. https://app.cochat.ai/papers/10.1056/nejm197608122950703
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- Doekel, R. C., Zwillich, C. W., Scoggin, C. H., Kryger, M., & Weil, J. V. (1976). Clinical Semi-Starvation: Depression of Hypoxic Ventilatory Response. New England Journal of Medicine. https://doi.org/10.1056/nejm197608122950703
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
