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Corticosteroids and Growth
Abstract
One the most conspicuous effects of the glucocorticoid hormones is an inhibition of somatic growth in immature animals. In 1940, shortly after adrenocortical hormones became available for experimental purposes, Wells and Kendall observed that small doses of cortisone promptly suppressed growth in the rat,1 and in the ensuing "steroid era" clinicians soon recognized that inhibition of growth is a prominent and often distressing problem in children treated chronically even with relatively low doses of adrenal corticosteroids. By the early 1960's several careful clinical studies had shown that as little as 45 mg of cortisone2 or 6 mg of prednisone3 per . . .
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Citations
Cited by
Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.
Canalis, E. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109908 · Cited by 386
Tomas, F. M., Munro, H. N., & Young, V. R. (1979) · Biochemical Journal · doi:10.1042/bj1780139 · Cited by 293
Oral glucocorticoids and their complications
Gallant, C., & Kenny, P. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70018-2 · Cited by 115
Metadata
- Authors
- Loeb, J. N.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-09-02
- Volume
- 295
- Issue
- 10
- Pages
- 547-552
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2026246057
- Cited by
- 250
- References
- 0
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Loeb, J. N. (1976). Corticosteroids and Growth. New England Journal of Medicine. https://doi.org/10.1056/nejm197609022951007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
