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Treatment of Hereditary Angioedema with Danazol: Reversal of Clinical and Biochemical Abnormalities
Abstract
Danazol, an androgen derivative, was evaluated for its effectiveness in preventing attacks of hereditary angioedema in a double-blind study with nine patients. Of 47 placebo courses, 44 ended with attacks, but during 46 danazol courses only one attack occurred. Side effects were minimal, and virilization was not observed in the women studied. C1 esterase inhibitor levels increased three to four times, and levels of the fourth component of complement (C4) increased 15 times. These changes began during the first day of therapy and were maximal by one to two weeks. After therapy was stopped, C1 esterase inhibitor and C4 levels rapidly decreased. Danazol effectively prevents attacks in hereditary angioedema and acts to correct the underlying biochemical abnormality.
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Cited by
Caballero, T., Farkas, H., Bouillet, L., Bowen, T., Gompel, A., Fagerberg, C., Bjökander, J., Bork, K., Bygum, A., Cicardi, M., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.025 · Cited by 254
Self-citationPotential involvement of the immune system in the development of endometriosis
Kyama, C. M., Debrock, S., Mwenda, J. M., & D'Hooghe, T. M. (2003) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-1-123 · Cited by 244
Drouet, C., Désormeaux, A., Robillard, J., Ponard, D., Bouillet, L., Martin, L., Kanny, G., Moneret-Vautrin, D.-A., Bosson, J.-L., Quesada, J.-L., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.10.048 · Cited by 112
Harrington, W. J., Sheremata, W. A., Snodgrass, S. R., Emerson, S., Phillips, S., & Berger, J. R. (1991) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1991.7.1031 · Cited by 67
Metadata
- Authors
- Gelfand, J. A., Sherins, R. J., Alling, D. W., & Frank, M. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1976-12-23
- Volume
- 295
- Issue
- 26
- Pages
- 1444-1448
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2004395480
- Cited by
- 607
- References
- 0
- FWCI
- 15.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gelfand, J. A., Sherins, R. J., Alling, D. W., & Frank, M. M. (1976). Treatment of Hereditary Angioedema with Danazol: Reversal of Clinical and Biochemical Abnormalities. New England Journal of Medicine. https://doi.org/10.1056/nejm197612232952602
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
