The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Galactorrhea: A Study of 235 Cases, Including 48 with Pituitary Tumors
Abstract
An analysis of 235 patients with galactorrhea (5.5 per cent males) showed that 20 per cent of all patients, and 34 per cent of women with associated amenorrhea, had radiologically evident pituitary tumors; these patients had the highest serum prolactin concentrations. The largest single group (32 per cent) consisted of women with idiopathic galactorrhea without amenorrhea; prolactin was normal in 86 per cent of these cases. Five patients had the empty-sella syndrome. Prolactin response was tested in selected patients by thyrotropin-releasing hormone, chlorpromazine, L-dopa, 24-hour sampling and other means. Tests with thyrotropin-releasing hormone were most useful in identifying patients with pituitary tumors. Surgery and radiotherapy lowered prolactin to a similar degree in patients with tumor, but galactorrhea, and amenorrhea often persisted after treatment. The ergot derivatives, bromergocryptine and lergotrile mesylate, lowered prolactin in all 18 patients with idiopathic hyperprolactinemia or pituitary tumor, stopped galactorrhea in over 50 per cent, restored menses in over 70 per cent, and allowed pregnancy in three.
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Citations
Cites
A Radioimmunoassay for Human Prolactin
Hwang, P., Guyda, H., & Friesen, H. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.8.1902 · Cited by 752
A possible role for prolactin in control of steroid secretion by the human Graafian follicle
MCNATTY, K. P., SAWERS, R. S., & MCNEILLY, A. S. (1974) · Nature · doi:10.1038/250653a0 · Cited by 462
Human Prolactin: 24-Hour Pattern with Increased Release during Sleep
Sassin, J. F., Frantz, A. G., Weitzman, E. D., & Kapen, S. (1972) · Science · doi:10.1126/science.177.4055.1205 · Cited by 460
Self-citationTashjian, A. H., Barowsky, N. J., & Jensen, D. K. (1971) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(71)90644-9 · Cited by 429
Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide
Bowers, C. Y., Friesen, H. G., Hwang, P., Guyda, H. J., & Folkers, K. (1971) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(71)90441-4 · Cited by 407
Wyk, J. J. V., & Grumbach, M. M. (1960) · The Journal of Pediatrics · doi:10.1016/s0022-3476(60)80250-8 · Cited by 386
(1972) · PubMed · Cited by 355
Jacobs, L. S., Snyder, P. J., Wilber, J. F., Utiger, R. D., & Daughaday, W. H. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-6-996 · Cited by 318
IRIE, M., & TSUSHIMA, T. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-1-97 · Cited by 272
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Cited by
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society Clinical Practice Guideline
Melmed, S., Casanueva, F. F., Hoffman, A. R., Kleinberg, D. L., Montori, V. M., Schlechte, J. A., & Wass, J. A. H. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1692 · Cited by 1,844
Self-citationThe clinical impact of the thyrotropin-releasing hormone test
FAGLIA, G. (1998) · Thyroid · doi:10.1089/thy.1998.8.903 · Cited by 91
Prevalence and predictors of hyperprolactinemia in subclinical hypothyroidism
Sharma, L. K., Sharma, N., Gadpayle, A. K., & Dutta, D. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.012 · Cited by 58
Montejo, Á. L., Arango, C., Bernardo, M., Carrasco, J. L., Crespo-Facorro, B., Cruz, J. J., del Pino, J., García Escudero, M. A., García Rizo, C., González-Pinto, A., et al. (2016) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2015.11.003 · Cited by 55
Bromocriptine treatment of prolactin-secreting pituitary adenomas may restore pituitary function
WARFIELD, A., FINKEL, D. M., SCHATZ, N. J., SAVINO, P. J., & SNYDER, P. J. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-6-783 · Cited by 47
Metadata
- Authors
- Kleinberg, D. L., Noel, G. L., & Frantz, A. G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-03-17
- Volume
- 296
- Issue
- 11
- Pages
- 589-600
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2064696831
- Cited by
- 560
- References
- 28
- FWCI
- 60.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Galactorrhea: A Study of 235 Cases, Including 48 with Pituitary Tumors. https://app.cochat.ai/papers/10.1056/nejm197703172961103
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- Kleinberg, D. L., Noel, G. L., & Frantz, A. G. (1977). Galactorrhea: A Study of 235 Cases, Including 48 with Pituitary Tumors. New England Journal of Medicine. https://doi.org/10.1056/nejm197703172961103
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
