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Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex Encephalitis: National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study
Abstract
We evaluated adenine arabinoside (vidarabine) for treatment of herpes simplex encephalitis in a placebo-controlled study. In 28 cases proved by isolation of Type 1 virus from brain biopsy, treatment reduced mortality from 70 to 28 per cent (P = 0.03), and over 50 per cent of treated survivors had no or only moderately debilitating neurologic sequelae. This improvement was achieved without evidence of acute drug toxicity. Thus, adenine arabinoside has a good therapeutic index (efficacy/toxicity) for the treatment of Type 1 herpes simplex encephalitis. However, the drug must be given early in the course of infection before the advent of coma to have a beneficial effect. Moreover, it should be coupled with brain biopsy for specific diagnosis to avoid unnecessary treatment of nonresponsive encephalitides that can mimic herpes simplex.
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Cited by
Herpes simplex virus infections
Whitley, R. J., & Roizman, B. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04638-9 · Cited by 1,366
Self-citationVidarabine versus Acyclovir Therapy in Herpes Simplex Encephalitis
Whitley, R. J., Alford, C. A., Hirsch, M. S., Schooley, R. T., Luby, J. P., Aoki, F. Y., Hanley, D., Nahmias, A. J., Soong, S.-J., & The NIAID Collaborative Antiviral Study Group* (1986) · New England Journal of Medicine · doi:10.1056/nejm198601163140303 · Cited by 896
Self-citationProbabilistic Sensitivity Analysis Using Monte Carlo Simulation: A Practical Approach
Doubilet, P., Begg, C. B., Weinstein, M. C., Braun, P., & McNeil, B. J. (1985) · Medical Decision Making · doi:10.1177/0272989x8500500205 · Cited by 860
ACYCLOVIR VERSUS VIDARABINE IN HERPES SIMPLEX ENCEPHALITIS
Sköldenberg, B., Alestig, K., Burman, L., Forkman, A., Lövgren, K., Norrby, R., Stiernstedt, G., Forsgren, M., Bergström, T., Dahlqvist, E., et al. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92623-0 · Cited by 610
Safrin, S., Crumpacker, C., Chatis, P., Davis, R., Hafner, R., Rush, J., Kessler, H. A., Landry, B., & Mills, J. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108223250805 · Cited by 375
Metadata
- Authors
- Whitley, R. J., Soong, S.-J., Dolin, R., Galasso, G. J., Ch'ien, L. T., Alford, C. A., & the Collaborative Study Group
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-08-11
- Volume
- 297
- Issue
- 6
- Pages
- 289-294
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2333553600
- Cited by
- 711
- References
- 0
- FWCI
- 58.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex Encephalitis: National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study. https://app.cochat.ai/papers/10.1056/nejm197708112970601
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- Whitley, R. J., Soong, S.-J., Dolin, R., Galasso, G. J., Ch'ien, L. T., Alford, C. A., & the Collaborative Study Group. (1977). Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex Encephalitis: National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study. New England Journal of Medicine. https://doi.org/10.1056/nejm197708112970601
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