The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Continuous Subcutaneous Administration of Deferoxamine in Patients with Iron Overload
Abstract
Since deferoxamine B, when administered as a single daily intramuscular injection of 0.75 g, is unable to promote sufficient urinary iron excretion to achieve net negative iron balance in siderosis, we evaluated its administration as a constant infusion over 24 hours. We compared intravenous and subcutaneous routes in 24 siderotic patients who had excreted 420 to 630 mg (mean, 480 mg) of iron per month on intramuscular therapy. With the intravenous route urinary iron excretions increased to 570 to 3690 mg (mean, 1595 mg) per month. Constant subcutaneous delivery was 90 per cent as effective as intravenous administration on a dose-for-dose basis. Noteworthy net cumulative urinary iron excretions (urinary iron excretions minus transfused iron), often in excess of 1 g per month, have been maintained in all patients. Constant subcutaneous deferoxamine administration may prove to be an effective and practical means of eliminating large quantities of iron in siderosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Desferal has been clinically used since the 1970s by the parenteral route for patients with iron overload, resulting from a variety of pathologies such as genetic hemochromatosis28 and repeated transfusion.29”
From Dual preventive benefits of iron elimination by desferal in asbestos‐induced mesothelial carcinogenesis (2016) · cites this paper as [29]
Citations
Cites
The Biochemistry of Desferrioxamine and its Relation to Iron Metabolism
Keberle, H. (1964) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb54077.x · Cited by 612
Buja, L. M., & Roberts, W. C. (1971) · The American Journal of Medicine · doi:10.1016/0002-9343(71)90240-3 · Cited by 472
Barry, M., Flynn, D. M., Letsky, E. A., & Risdon, R. A. (1974) · BMJ · doi:10.1136/bmj.2.5909.16 · Cited by 326
Denson, K. W. E., & Ef, B. (1961) · PubMed · Cited by 234
Reassessment of the Use of Desferrioxamine B in Iron Overload
Propper, R. D., Shurin, S. B., & Nathan, D. G. (1976) · New England Journal of Medicine · doi:10.1056/nejm197606242942603 · Cited by 180
Self-citationHemochromatosis and Hemosiderosis
MacDonald, R. A. (1963) · Kanzo · doi:10.2957/kanzo.5.34 · Cited by 123
Cardiac Involvement in Cooley's Anemia
Engle, M. A. (1964) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb54070.x · Cited by 122
LONG‐TERM DESFERRIOXAMINE THERAPY IN THALASSEMIA
Modell, C. B., & Beck, J. (1974) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1974.tb20586.x · Cited by 117
Hussain, M. (1976) · The Lancet · doi:10.1016/s0140-6736(76)92035-3 · Cited by 107
ASCORBIC ACID ENHANCEMENT OF DESFERRIOXAMINE‐INDUCED URINARY IRON EXCRETION IN THALASSEMIA MAJOR*
O’Brien, R. T. (1974) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1974.tb20588.x · Cited by 101
Research works printed but not linked: 8
- Ellis, 1954, Am J Pathol, 30, 287
- Wyatt, 1950, Am J Pathol, 26, 883
- Fahey, 1961, J Lab Clin Med, 57, 436
- Nienhuis, 1976, Birth Defects, 12, 177
- Propper, 1976, Blood, 48, 964
- Propper, 1976, Pediatr Res, 10, 380
- Denson, 1961, Clin Sci, 21, 157
- Gevirtz, 1965, Am J Clin Nutr, 16, 389
Cited by
Survival in Medically Treated Patients with Homozygous β-Thalassemia
Olivieri, N. F., Nathan, D. G., MacMillan, J. H., Wayne, A. S., Liu, P. P., McGee, A., Martin, M., Koren, G., & Cohen, A. R. (1994) · New England Journal of Medicine · doi:10.1056/nejm199409013310903 · Cited by 852
Self-citationMicrobial siderophores and their potential applications: a review
Saha, M., Sarkar, S., Sarkar, B., Sharma, B. K., Bhattacharjee, S., & Tribedi, P. (2016) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-4294-0 · Cited by 819
Intramuscular desferrioxamine in patients with Alzheimer's disease
MCLACHLAN, D. (1991) · The Lancet · doi:10.1016/0140-6736(91)92978-b · Cited by 764
IRON ABSORPTION AND LOADING IN β-THALASSÆMIA INTERMEDIA
Pippard, M. J., Warner, G. T., Callender, S. T., & Weatherall, D. J. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92175-5 · Cited by 419
Perspectives in Iron Metabolism
Finch, C. A., & Huebers, H. (1982) · New England Journal of Medicine · doi:10.1056/nejm198206243062504 · Cited by 391
Metadata
- Authors
- Propper, R. D., Cooper, B., Rufo, R. R., Nienhuis, A. W., Anderson, W. F., Bunn, H. F., Rosenthal, A., & Nathan, D. G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-08-25
- Volume
- 297
- Issue
- 8
- Pages
- 418-423
- ISSN
- 0028-4793
- 1533-4406
- Cited by
- 258
- References
- 21
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Continuous Subcutaneous Administration of Deferoxamine in Patients with Iron Overload. https://app.cochat.ai/papers/10.1056/nejm197708252970804
- The paper
- Propper, R. D., Cooper, B., Rufo, R. R., Nienhuis, A. W., Anderson, W. F., Bunn, H. F., Rosenthal, A., & Nathan, D. G. (1977). Continuous Subcutaneous Administration of Deferoxamine in Patients with Iron Overload. New England Journal of Medicine. https://doi.org/10.1056/nejm197708252970804
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
