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Cited by 326

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Long-term Chelation Therapy in Thalassaemia Major: Effect on Liver Iron Concentration, Liver Histology, and Clinical Progress

Open access
Barry, Michael, Flynn, David M., Letsky, Elizabeth A., Risdon, R. A.·1974·BMJ
DOI 10.1136/bmj.2.5909.16
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Abstract

A prospective trial of continuous chelation therapy in children with homozygous thalassaemia on a high transfusion regimen was started in April 1966. The effect of treatment on iron concentration in the liver and on hepatic histology was examined in 49 biopsy specimens obtained from nine chelator-treated patients and nine control patients between April 1966 and April 1973. Chelation therapy was associated with a significant reduction in liver iron concentration, and by the end of the trial the values for the two groups showed no overlap. A similar difference was seen in the amount of hepatic fibrosis, which showed little or no change in the chelator-treated patients but was progressive in the controls. No major clinical differences were seen, probably because both groups included several older children who were heavily loaded with iron at the start of the trial. Among the younger patients, however, puberty was delayed in four of five controls but in only one of four chelator-treated children. Prepubertal growth rate was significantly greater in the chelator-treated patients than in the controls.

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Metadata

Authors
Barry, M., Flynn, D. M., Letsky, E. A., & Risdon, R. A.
Venue
BMJ
Publisher
BMJ
Published
1974-04-06
Volume
2
Issue
5909
Pages
16-20
ISSN
  • 0007-1447 (ISSN-L)
  • 1468-5833
DOI
10.1136/bmj.2.5909.16
OpenAlex
W2074602083
Cited by
326
References
9
FWCI
8.18
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Long-term Chelation Therapy in Thalassaemia Major: Effect on Liver Iron Concentration, Liver Histology, and Clinical Progress. https://app.cochat.ai/papers/10.1136/bmj.2.5909.16
The paper
Barry, M., Flynn, D. M., Letsky, E. A., & Risdon, R. A. (1974). Long-term Chelation Therapy in Thalassaemia Major: Effect on Liver Iron Concentration, Liver Histology, and Clinical Progress. BMJ. https://doi.org/10.1136/bmj.2.5909.16

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.