The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Natural History of Lactic Acidosis after Grand-Mal Seizures: A Model for the Study of an Anion-Gap Acidosis Not Associated with Hyperkalemia
Abstract
To define the time course of the metabolic acidosis that follows a single grand-mal seizure, we obtained serial blood samples from eight consecutive patients. Immediately after a seizure, the mean (+/- S.E.M.) venous lactate concentration was 12.7 +/- 1.0 meq per liter, the mean carbon dioxide content 17.1 +/- 1.1 mmol per liter, and the mean arterial pH 7.14 +/- 0.06. Sixty minutes later their values were 6.6 +/- 0.7 meq per liter (P less than 0.005), 23.6 +/- 1.1 mmol per liter (P less than 0.005) and 7.38 +/- 0.04 (P less than 0.005) respectively. The spontaneous resolution of the acidosis was due, in large part, to the metabolism of lactate and to the concomitant removal of hydrogen ion. There was no change in the serum potassium concentration, despite the development of a severe systemic acidemia and the subsequent return to normal of the pH. We suggest that the patient with seizures may serve as a unique model of lactic acidosis.
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Cites
Acid-base balance after maximal exercise of short duration
Osnes, J. B., & Hermansen, L. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.1.59 · Cited by 204
Cited by
Etiology and Therapeutic Approach to Elevated Lactate Levels
Andersen, L. W., Mackenhauer, J., Roberts, J. C., Berg, K. M., Cocchi, M. N., & Donnino, M. W. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.06.012 · Cited by 731
Samrén, E. B., van Duijn, C. M., Koch, S., Hiilesmaa, V. K., Klepel, H., Bardy, A. H., Mannagetta, G. B., Deichl, A. W., Gaily, E., Granström, I. L., et al. (1997) · Epilepsia · doi:10.1111/j.1528-1157.1997.tb01480.x · Cited by 406
Changes in plasma potassium concentration during acute acid-base disturbances
Adrogué, H. J., & Madias, N. E. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90182-0 · Cited by 388
Prospective evaluation of syncope
Martin, G. J., Adams, S. L., Martin, H. G., Mathews, J., Zull, D., & Scanlon, P. J. (1984) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(84)80511-9 · Cited by 239
Regulation of lactate metabolism in vivo
Buchalter, S. E., Crain, M. R., & Kreisberg, R. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050405 · Cited by 69
Metadata
- Authors
- Orringer, C. E., Eustace, J. C., Wunsch, C. D., & Gardner, L. B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-10-13
- Volume
- 297
- Issue
- 15
- Pages
- 796-799
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2335770946
- Cited by
- 288
- References
- 1
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Orringer, C. E., Eustace, J. C., Wunsch, C. D., & Gardner, L. B. (1977). Natural History of Lactic Acidosis after Grand-Mal Seizures: A Model for the Study of an Anion-Gap Acidosis Not Associated with Hyperkalemia. New England Journal of Medicine. https://doi.org/10.1056/nejm197710132971502
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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