The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Etiology and Therapeutic Approach to Elevated Lactate Levels
Open accessAbstract
Lactate levels are commonly evaluated in acutely ill patients. Although most commonly used in the context of evaluating shock, lactate can be elevated for many reasons. While tissue hypoperfusion is probably the most common cause of elevation, many other etiologies or contributing factors exist. Clinicians need to be aware of the many potential causes of lactate elevation as the clinical and prognostic importance of an elevated lactate varies widely by disease state. Moreover, specific therapy may need to be tailored to the underlying cause of elevation. The current review is based on a comprehensive PubMed search and contains an overview of the pathophysiology of lactate elevation followed by an in-depth look at the varied etiologies, including medication-related causes. The strengths and weaknesses of lactate as a diagnostic/prognostic tool and its potential use as a clinical endpoint of resuscitation will be discussed. The review ends with some general recommendations on management of patients with elevated lactate.
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Cites
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
Salpeter, S. R., Greyber, E., Pasternak, G. A., & Salpeter (posthumous), E. E. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002967.pub4 · Cited by 893
Lactate kinetics in human tissues at rest and during exercise
van Hall, G. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02122.x · Cited by 346
Seizures associated with recreational drug abuse
Alldredge, B. K., Lowenstein, D. H., & Simon, R. P. (1989) · Neurology · doi:10.1212/wnl.39.8.1037 · Cited by 185
Martinschek, A., Evers, B., Lampl, L., Gerngroß, H., Schmidt, R., & Sparwasser, C. (2012) · Urologia Internationalis · doi:10.1159/000339161 · Cited by 112 · cited 1×
“In Fournier gangrene and other types of necrotizing soft-tissue infections, lactate has been associated with mortality.(73-75)”
BackgroundDiagnostic pitfalls at admission in patients with acute superior mesenteric artery occlusion
Acosta, S., Block, T., Björnsson, S., Resch, T., Björck, M., & Nilsson, T. (2012) · The Journal of Emergency Medicine · doi:10.1016/j.jemermed.2011.03.036 · Cited by 65
Cited by
Validation of a point-of-care capillary lactate measuring device (Lactate Pro 2)
Raa, A., Sunde, G. A., Bolann, B., Kvåle, R., Bjerkvig, C., Eliassen, H. S., Wentzel-Larsen, T., & Heltne, J.-K. (2020) · Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine · doi:10.1186/s13049-020-00776-z · Cited by 36
Tan, Y., Dede, M., Mohanty, V., Dou, J., Hill, H., Bernstam, E., & Chen, K. (2024) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2024.104648 · Cited by 19
Chehayeb, R. J., Ilagan-Ying, Y. C., & Sankey, C. (2023) · Journal of General Internal Medicine · doi:10.1007/s11606-023-08091-w · Cited by 4
Metadata
- Authors
- Andersen, L. W., Mackenhauer, J., Roberts, J. C., Berg, K. M., Cocchi, M. N., & Donnino, M. W.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 88
- Issue
- 10
- Pages
- 1127-1140
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W2072945343
- Cited by
- 731
- References
- 6
- FWCI
- 19.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Andersen, L. W., Mackenhauer, J., Roberts, J. C., Berg, K. M., Cocchi, M. N., & Donnino, M. W. (2013). Etiology and Therapeutic Approach to Elevated Lactate Levels. Mayo Clinic Proceedings. https://doi.org/10.1016/j.mayocp.2013.06.012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
