The DOI matches its Crossref record.
Effect of Hypophosphatemia on Myocardial Performance in Man
Abstract
Severe hypophosphatemia is associated in man with low intracellular stores of ATP and a set of specific cellular dysfunctions. To investigate whether hypophosphatemia affects myocardial performance, we measured cardiac output by thermodilution and calculated stroke work in seven patients with severe hypophosphatemia before, during and after repletion with an intravenous potassium phosphate solution. Mean left ventricular stroke work for these patients increased from 49.57 to 71.71 g-m per beat (P less than 0.01) at the same or higher afterload whereas pulmonary-artery wedge pressure fell from a mean value of 10.1 to 6.7 torr (P less than 0.02). Return of serum phosphate to normal, therefore, improved myocardial stroke work independently of the Starling effect. The mechanism of this improvement in contractile force is unknown but may be related to intracellular availability of ATP.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
FGF23 induces left ventricular hypertrophy
Faul, C., Amaral, A. P., Oskouei, B., Hu, M.-C., Sloan, A., Isakova, T., Gutiérrez, O. M., Aguillon-Prada, R., Lincoln, J., Hare, J. M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46122 · Cited by 2,027
Wolfsdorf, J. I., Glaser, N., Agus, M., Fritsch, M., Hanas, R., Rewers, A., Sperling, M. A., & Codner, E. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12701 · Cited by 710
Diabetic ketoacidosis and hyperglycemic hyperosmolar state
Wolfsdorf, J. I., Allgrove, J., Craig, M. E., Edge, J., Glaser, N., Jain, V., Lee, W. W., Mungai, L. N., Rosenbloom, A. L., Sperling, M. A., et al. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12165 · Cited by 371
Weisinger, J. R., & Bellorín-Font, E. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10535-9 · Cited by 357
Review of the Refeeding Syndrome
Kraft, M. D., Btaiche, I. F., & Sacks, G. S. (2005) · Nutrition in Clinical Practice · doi:10.1177/0115426505020006625 · Cited by 316
Metadata
- Authors
- O'Connor, L. R., Wheeler, W. S., & Bethune, J. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-10-27
- Volume
- 297
- Issue
- 17
- Pages
- 901-903
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1972092932
- Cited by
- 292
- References
- 0
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of Hypophosphatemia on Myocardial Performance in Man. https://app.cochat.ai/papers/10.1056/nejm197710272971702
- The paper
- O'Connor, L. R., Wheeler, W. S., & Bethune, J. E. (1977). Effect of Hypophosphatemia on Myocardial Performance in Man. New England Journal of Medicine. https://doi.org/10.1056/nejm197710272971702
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
