FGF23 induces left ventricular hypertrophy
Open accessAbstract
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiovascular disease in individuals with CKD. Elevated levels of FGF23 have been linked to greater risks of LVH and mortality in patients with CKD, but whether these risks represent causal effects of FGF23 is unknown. Here, we report that elevated FGF23 levels are independently associated with LVH in a large, racially diverse CKD cohort. FGF23 caused pathological hypertrophy of isolated rat cardiomyocytes via FGF receptor-dependent activation of the calcineurin-NFAT signaling pathway, but this effect was independent of klotho, the coreceptor for FGF23 in the kidney and parathyroid glands. Intramyocardial or intravenous injection of FGF23 in wild-type mice resulted in LVH, and klotho-deficient mice demonstrated elevated FGF23 levels and LVH. In an established animal model of CKD, treatment with an FGF-receptor blocker attenuated LVH, although no change in blood pressure was observed. These results unveil a klotho-independent, causal role for FGF23 in the pathogenesis of LVH and suggest that chronically elevated FGF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Data from animal studies and healthy subjects indicate that longer treatment with high Pi can lead to cardiac remodeling in animals and higher blood pressure in humans.
“Data from animal studies and healthy subjects indicate that longer treatment with high Pi can lead to cardiac remodeling in animals and higher blood pressure in humans [19, 35, 42].”
From Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels (2025) · cites this paper as [19]
Cites
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E., & Hsu, C.-Y. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041031 · Cited by 11,369 · see citing works
Self-citationLang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318 · see citing works
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699 · see citing works
Prevalence of Chronic Kidney Disease in the United States
Coresh, J., Selvin, E., Stevens, L. A., Manzi, J., Kusek, J. W., Eggers, P., Van Lente, F., & Levey, A. S. (2007) · JAMA · doi:10.1001/jama.298.17.2038 · Cited by 4,895 · see citing works
Self-citationMutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Self-citationA Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Molkentin, J. D., Lu, J., Antos, C. L., Markham, B. E., Richardson, J. A., Robbins, J. M., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566 · see citing works
Ornitz, D. M., & Itoh, N. (2001) · Genome biology · doi:10.1186/gb-2001-2-3-reviews3005 · Cited by 1,985 · see citing works
Cellular signaling by fibroblast growth factor receptors
Eswarakumar, V. P., Lax, I., & Schlessinger, J. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.001 · Cited by 1,923 · see citing works
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871 · see citing works
Regulation of cardiac hypertrophy by intracellular signalling pathways
Heineke, J., & Molkentin, J. D. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1983 · Cited by 1,856 · see citing works
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,846 · see citing works
Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis
Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh‐Hain, J. A., Tamez, H. E., Shah, A., Smith, K. T., Lee, H., Thadhani, R., Jüppner, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706130 · Cited by 1,729 · see citing works
Self-citationCardiac Hypertrophy: The Good, the Bad, and the Ugly
Frey, N., & Olson, E. N. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142243 · Cited by 1,458 · see citing works
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
Shimada, T., Mizutani, S., Muto, T., Yoneya, T., Hino, R., Takeda, S., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.101545198 · Cited by 1,391 · see citing works
Regulation of Fibroblast Growth Factor-23 Signaling by Klotho*
Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K., Baum, M., Schiavi, S., Hu, M.-C., Moe, O., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500457200 · Cited by 1,356 · see citing works
Self-citationCrabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323 · see citing works
Clinical and echocardiographic disease in patients starting end-stage renal disease therapy
Foley, R. N., Parfrey, P. S., Harnett, J. D., Kent, G. M., Martin, C. J., Murray, D. C., & Barré, P. E. (1995) · Kidney International · doi:10.1038/ki.1995.22 · Cited by 1,294 · see citing works
Isakova, T., on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Group, WAHL, P. W., Vargas, G. S., Gutiérrez, O. M., Scialla, J. J., Xie, H., Appleby, D. H., Nessel, L. C., Bellovich, K. A., et al. (2011) · Kidney International · doi:10.1038/ki.2011.47 · Cited by 1,271 · see citing works
Self-citationReceptor Specificity of the Fibroblast Growth Factor Family
Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M., & Ornitz, D. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601252200 · Cited by 1,164 · see citing works
Amado, L. C., SALIARIS, A. P., Schuleri, K. H., John, M. S., Xie, J.-S., Cattaneo, S. M., Durand, D. J., Fitton, T. P., Kuang, J. Q., Stewart, G. C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504388102 · Cited by 1,072 · see citing works
Self-citationIsakova, T. (2011) · JAMA · doi:10.1001/jama.2011.826 · Cited by 1,023 · see citing works
Self-citationFaul, C., Donnelly, M., Merscher, S., Chang, Y. H., Franz, S., Delfgaauw, J., Chang, J., Choi, H. Y., Campbell, K. N., Kim, K., et al. (2008) · Nature Medicine · doi:10.1038/nm.1857 · Cited by 993 · see citing works
Self-citationThe parathyroid is a target organ for FGF23 in rats
Ben‐Dov, I. Z., Galitzer, H., Lavi-Moshayoff, V., Goetz, R. M., Kuro‐o, M., Mohammadi, M., Sirkis, R., Naveh‐Many, T., & Silver, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32409 · Cited by 951 · see citing works
Self-citationKlotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease
Hu, M. C., Shi, M., Zhang, J., Quiñones, H., Griffith, C. S., Kuro‐o, M., & Moe, O. W. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009121311 · Cited by 933 · see citing works
Self-citationGutiérrez, O. M., Isakova, T., Rhee, E. P., Shah, A., Holmes, J., Collerone, G., Diaeresis]ppner, H. J., & Wolf, M. S. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010052 · Cited by 920 · see citing works
Self-citationImmunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.
Bader, D. M., Masaki, Τ., & Fischman, D. A. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.3.763 · Cited by 919 · see citing works
Fibroblast Growth Factor 23 in Oncogenic Osteomalacia and X-Linked Hypophosphatemia
Jonsson, K. B., Zahradnik, R. J., Larsson, T. E., White, K. E., Sugimoto, T., Imanishi, Y., Yamamoto, T., Hampson, G., Koshiyama, H., Ljunggren, Ö., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020881 · Cited by 904 · see citing works
Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease
Gutiérrez, O. M., Januzzi, J. L., Isakova, T., Laliberte, K. A., Smith, K. T., Collerone, G., Sarwar, A., Hoffmann, U., Coglianese, E. E., Christenson, R. H., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.844506 · Cited by 840 · see citing works
Self-citationThe MEK1–ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
Bueno, O. F., Windt, L. J. D., Tymitz, K. M., Witt, S. A., Kimball, T. R., Klevitsky, R., Hewett, T. E., Jones, S. P., Lefer, D. J., Peng, C., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6341 · Cited by 774 · see citing works
The Chronic Renal Insufficiency Cohort (CRIC) Study
Feldman, H. I., Appel, L. J., Chertow, G. M., Cifelli, D., Čižman, B., Daugirdas, J. T., Fink, J. C., Franklin-Becker, E. D., Go, A. S., Hamm, L. L., et al. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000070149.78399.ce · Cited by 660 · see citing works
Self-citationThe conserved phosphoinositide 3‐kinase pathway determines heart size in mice
Shioi, T., Kang, P., Douglas, P., Hampe, J., Yballe, C., Lawitts, J., Cantley, L., & Izumo, S. (2000) · EMBO Journal · doi:10.1093/emboj/19.11.2537 · Cited by 646 · see citing works
Protein kinase cascades in the regulation of cardiac hypertrophy
Dorn, G. W., & Force, T. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24178 · Cited by 637 · see citing works
Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction
Jaye, M., Schlessinger, J., & Dionne, C. A. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(92)90136-y · Cited by 617 · see citing works
Goetz, R., Beenken, A., Ibrahimi, O., Kalinina, J., Olsen, S., Eliseenkova, A. V., Xu, C.-F., Neubert, T., Zhang, F.-M., Linhardt, R., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02249-06 · Cited by 544 · see citing works
Self-citationMyosin isoenzyme redistribution in chronic heart overload
Lompré, A., Schwartz, K., d’Albis, A., Lacombe, G., Thiem, N. V., & Bernard Swynghedauw, A. (1979) · Nature · doi:10.1038/282105a0 · Cited by 523 · see citing works
Sugden, P. H., & Clerk, A. (1998) · Circulation Research · doi:10.1161/01.res.83.4.345 · Cited by 519 · see citing works
Molkentin, J. D. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.021 · Cited by 498 · see citing works
MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets
Muslin, A. J. (2008) · Clinical Science · doi:10.1042/cs20070430 · Cited by 496 · see citing works
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
Mohammadi, M., Froum, S., Hamby, J. M., Schroeder, M. C., Panek, R. L., Lu, G. H., Eliseenkova, A. V., Green, D., Schlessinger, J., & Hubbard, S. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.20.5896 · Cited by 484 · see citing works
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, C. L., McKinsey, T. A., Frey, N., Kutschke, W. J., McAnally, J., Shelton, J. M., Richardson, J. A., Hill, J. A., & Olson, E. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231619298 · Cited by 477 · see citing works
Self-citationRegulation of MAPKs by growth factors and receptor tyrosine kinases
Katz, M., Amit, I., & Yarden, Y. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.01.002 · Cited by 468 · see citing works
Alterations of Left Ventricular Hypertrophy in and Survival of Patients Receiving Hemodialysis
London, G. M., Pannier, B., Guérin, A. P., Blacher, J., Marchais, S. J., Darné, B. M., Métivier, F., Adda, H., & Safar, M. E. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v12122759 · Cited by 465 · see citing works
Parker, B. D., Schurgers, L. J., Brandenburg, V. M., Christenson, R. H., Vermeer, C., Ketteler, M., Shlipak, M. G., Whooley, M. A., & Ix, J. H. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-10-201005180-00004 · Cited by 457 · see citing works
Izumo, S., Lompré, A., Matsuoka, R., Koren, G., Schwartz, K., Nadal‐Ginard, B., & Mahdavi, V. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112908 · Cited by 447 · see citing works
Calcium–calcineurin signaling in the regulation of cardiac hypertrophy
Wilkins, B. J., & Molkentin, J. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.121 · Cited by 439 · see citing works
Bogoyevitch, M. A., Glennon, P. E., Andersson, M., Clerk, A., Lazou, A., Marshall, C. J., Parker, P. J., & Sugden, P. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42228-9 · Cited by 388 · see citing works
Parker, T. G., Packer, S. E., & Schneider, M. D. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114466 · Cited by 376 · see citing works
Early Control of PTH and FGF23 in Normophosphatemic CKD Patients
de Oliveira, R. C., Cancela, A. L. E., Graciolli, F. G., dos Reis, L. M., Draibe, S. A., Cuppari, L., Carvalho, A. B., Jorgetti, V., Canziani, M. E. F., & Moysés, R. M. A. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05420709 · Cited by 357 · see citing works
Jean, G., Terrat, J.-C., Vanel, T., Hurot, J. M., Lorriaux, C., Mayor, B., & Chazot, C. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp191 · Cited by 351 · see citing works
Control of Cardiac Gene Expression by Mechanical Stress
Komuro, I., & Yazaki, Y. (1993) · Annual Review of Physiology · doi:10.1146/annurev.ph.55.030193.000415 · Cited by 344 · see citing works
Mirza, M. A. I., Larsson, A. O., Melhus, H., Lind, L., & Larsson, T. E. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.05.013 · Cited by 341 · see citing works
Hasegawa, H., Nagano, N., Urakawa, I., Yamazaki, Y., Iijima, K., Fujita, T., Yamashita, T., Fukumoto, S., & Shimada, T. (2010) · Kidney International · doi:10.1038/ki.2010.313 · Cited by 339 · see citing works
Molkentin, J. D., Kalvakolanu, D. V., & Markham, B. E. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4947 · Cited by 309 · see citing works
Forging Forward with 10 Burning Questions on FGF23 in Kidney Disease
Wolf, M. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009121293 · Cited by 306 · see citing works
Self-citationUse of tibial length to quantify cardiac hypertrophy: application in the aging rat
Yin, F. C. P., Spurgeon, H. A., Rakusan, K., Weisfeldt, M. L., & Lakatta, E. G. (1982) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1982.243.6.h941 · Cited by 296 · see citing works
Left Ventricular Hypertrophy in the Renal Patient
Middleton, R., Parfrey, P. S., & Foley, R. N. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1251079 · Cited by 294 · see citing works
Effect of Hypophosphatemia on Myocardial Performance in Man
O'Connor, L. R., Wheeler, W. S., & Bethune, J. E. (1977) · New England Journal of Medicine · doi:10.1056/nejm197710272971702 · Cited by 292 · see citing works
Prognostic Impact of the Indexation of Left Ventricular Mass in Patients Undergoing Dialysis
Zoccali, C., Benedetto, F. A., Mallamaci, F., Tripepi, G. L., Giacone, G., Cataliotti, A., Seminara, G., Stancanelli, B., & Malatino, L. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v12122768 · Cited by 292 · see citing works
Hughes, S. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704500710 · Cited by 283 · see citing works
Bai, X., Miao, D., Goltzman, D., & Karaplis, A. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210490200 · Cited by 274 · see citing works
Wang, H., Yoshiko, Y., Yamamoto, R., Minamizaki, T., Kozai, K., Tanne, K., Aubin, J. E., & Maeda, N. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080220 · Cited by 263 · see citing works
Galitzer, H., Ben‐Dov, I. Z., Silver, J., & Naveh‐Many, T. (2009) · Kidney International · doi:10.1038/ki.2009.464 · Cited by 246 · see citing works
Control of cardiac myosin heavy chain gene expression
Morkin, E. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20000915)50:6 · Cited by 239 · see citing works
Shimada, T., Urakawa, I., Isakova, T., Yamazaki, Y., Epstein, M., Wesseling‐Perry, K., Wolf, M. S., Salusky, I. B., & Jüppner, H. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1603 · Cited by 230 · see citing works
Self-citationLeft Ventricular Hypertrophy in Nondiabetic Predialysis CKD
Paoletti, E., Bellino, D., Cassottana, P., Rolla, D., & Cannella, G. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.04.031 · Cited by 218 · see citing works
Analysis of the Biochemical Mechanisms for the Endocrine Actions of Fibroblast Growth Factor-23
Yu, X., Ibrahimi, O. A., Goetz, R. M., Zhang, F., Davis, S. I., Garringer, H. J., Linhardt, R. J., Ornitz, D. M., Mohammadi, M., & White, K. E. (2005) · Endocrinology · doi:10.1210/en.2005-0670 · Cited by 213 · see citing works
Zoccali, C., Benedetto, F. A., Mallamaci, F., Tripepi, G. L., Giacone, G., Cataliotti, A., Seminara, G., Stancanelli, B., & Malatino, L. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000117977.14912.91 · Cited by 205 · see citing works
Biological activities of fibroblast growth factor-2 in the adult myocardium
Detillieux, K. A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00708-3 · Cited by 201 · see citing works
Bishopric, N. H., Simpson, P. C., & Ordahl, C. P. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113179 · Cited by 200 · see citing works
The Klotho gene family as a regulator of endocrine fibroblast growth factors.
Kurosu, H., & Kuro-o, M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.052 · Cited by 196 · see citing works
Self-citationFatty Acid Utilization in the Hypertrophied and Failing Heart: Molecular Regulatory Mechanisms
Barger, P. M., & Kelly, D. P. (1999) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199907000-00006 · Cited by 192 · see citing works
Lincoln, J., Kist, R., Scherer, G., & Yutzey, K. E. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.002 · Cited by 187 · see citing works
Self-citationIMPACT OF RENAL TRANSPLANTATION ON UREMIC CARDIOMYOPATHY
Parfrey, P. S., Harnett, J. D., Foley, R. N., Kent, G. M., Murray, D. C., Barré, P. E., & Guttmann, R. D. (1995) · Transplantation · doi:10.1097/00007890-199511000-00005 · Cited by 173 · see citing works
Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation
Frey, N., Frank, D., Lippl, S., Kühn, C., Kögler, H., Barrientos, T., Rohr, C. M., Will, R. D., Müller, O. J., Weiler-Guettler, H., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36277 · Cited by 148 · see citing works
The Cytoskeleton and Related Proteins in the Human Failing Heart
Sawa Kostin, D., Hein, S., Arnon, E., Scholz, D., & Schaper, J. (2000) · Heart Failure Reviews · doi:10.1023/a:1009813621103 · Cited by 143 · see citing works
Control of Cardiac Growth and Function by Calcineurin Signaling
Vega, R. B., Bassel‐Duby, R., & Olson, E. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300023200 · Cited by 132 · see citing works
Harmer, N. J., Pellegrini, L., Chirgadze, D., Fernández‐Recio, J., & Blundell, T. L. (2003) · Biochemistry · doi:10.1021/bi035320k · Cited by 124 · see citing works
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy
Buitrago, M. A. B., Lorenz, K., Maass, A. H., Oberdorf‐Maass, S. U., Keller, U., Schmitteckert, E. M., Ivashchenko, Y., Lohse, M. J., & Engelhardt, S. H. (2005) · Nature Medicine · doi:10.1038/nm1272 · Cited by 116 · see citing works
IMPACT OF RENAL TRANSPLANTATION ON UREMIC CARDIOMYOPATHY
Parfrey, P. S., Harnett, J. D., Foley, R. N., Kent, G. M., Murray, D. C., Barré, P. E., & Guttmann, R. D. (1995) · Transplantation · doi:10.1097/00007890-199511150-00005 · Cited by 114 · see citing works
Reversible depression in myocardial performance in dogs with experimental phosphorus deficiency.
Fuller, T. J., Nichols, W., Brenner, B. J., & Peterson, J. C. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109239 · Cited by 106 · see citing works
Toraason, M. A., Luken, M. E., Breitenstein, M. J., KRUEGER, J. A., & Biagini, R. E. (1989) · Toxicology · doi:10.1016/0300-483x(89)90216-3 · Cited by 103 · see citing works
Faul, C., Dhume, A., Schecter, A. D., & Mundel, P. H. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00950-07 · Cited by 86 · see citing works
Self-citationFinch, J. L., Tokumoto, M., Nakamura, H. K., Yao, W., Shahnazari, M., Lane, N. E., & Slatopolsky, E. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00552.2009 · Cited by 81 · see citing works
Trophic Effect of Human Pericardial Fluid on Adult Cardiac Myocytes
Corda, S., Mebazaa, A., Gandolfini, M.-P., Fitting, C., Marotte, F., Peynet, J., Charlemagne, D., Cavaillon, J., Payen, D. M., Rappaport, L., et al. (1997) · Circulation Research · doi:10.1161/01.res.81.5.679 · Cited by 80 · see citing works
Cardiovascular Abnormalities in Patients with X-Linked Hypophosphatemia
Nehgme, R., Fahey, J. T., Smith, C. R., & Carpenter, T. O. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4181 · Cited by 77 · see citing works
Fibroblast growth factor 2 isoforms and cardiac hypertrophy
Kardami, E. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.04.024 · Cited by 71 · see citing works
Stimulus specific changes of energy metabolism in hypertrophied heart
Rimbaud, S., Sanchez, H., Garnier, A., Fortin, D., Bigard, X. A., Veksler, V., & Ventura‐Clapier, R. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.01.013 · Cited by 54 · see citing works
Faul, C., Hüttelmaier, S., Oh, J. S., Hachet, V., Singer, R. H., & Mundel, P. H. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411169 · Cited by 50 · see citing works
Self-citationCardioprotective effect of calcineurin inhibition in an animal model of renal disease
Marco, G. S. D., Reuter, S., Kentrup, D., Ting, L., Liu, T., Grabner, A., Jacobi, A. M., Pavenstädt, H., Baba, H. A., Tiemann, K., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq436 · Cited by 39 · see citing works
Self-citationBasic fibroblast growth factor induces myocardial hypertrophy following acute infarction in rats
Scheinowitz, M., Kotlyar, A., Zimand, S., Ohad, D. G., Leibovitz, I., Bloom, N., Goldberg, I., Nass, D., Engelberg, S., Savion, N., et al. (1998) · Experimental Physiology · doi:10.1113/expphysiol.1998.sp004140 · Cited by 28 · see citing works
Flagged first, then by citations
1 of the 92 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782 · see citing works
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050 · see citing works
Inker, L. A., Astor, B. C., Fox, C. H., Isakova, T., Lash, J. P., Peralta, C. A., Tamura, M. K., & Feldman, H. I. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.01.416 · Cited by 1,783 · see citing works
Self-citationRangaswami, J., Bhalla, V., Blair, J. E., Chang, T. I., Costa, S. P., Lentine, K. L., Lerma, E. V., Mezue, K. N., Molitch, M. E., Müllens, W., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000664 · Cited by 1,479 · see citing works
The Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042 · see citing works
The Klotho proteins in health and disease
Kuro-o, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0078-3 · Cited by 707 · see citing works
Self-citationEpidemiology and risk of cardiovascular disease in populations with chronic kidney disease
Matsushita, K., Ballew, S. H., Wang, A. Y.-M., Kalyesubula, R., Schäeffner, E., & Agarwal, R. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00616-6 · Cited by 698 · see citing works
Nutritional Management of Chronic Kidney Disease
Kalantar-Zadeh, K., & Fouque, D. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1700312 · Cited by 636 · see citing works
Hu, M. C., Shiizaki, K., Kuro-o, M., & Moe, O. W. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183727 · Cited by 587 · see citing works
Self-citationCardiovascular disease in dialysis patients
Cozzolino, M. G., Mangano, M., Stucchi, A., Ciceri, P., Conte, F., & Galassi, A. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy174 · Cited by 576 · see citing works
Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy
Grabner, A., Amaral, A. P., Schramm, K. J., Singh, S., Sloan, A. J., Yanucil, C., Li, J., Shehadeh, L. A., Hare, J. M., David, V., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.002 · Cited by 546 · see citing works
Self-citationEffects of Phosphate Binders in Moderate CKD
Block, G. A., Wheeler, D. C., Persky, M. S., Kestenbaum, B. R., Ketteler, M., Spiegel, D. M., Allison, M., Asplin, J. R., Smits, G., Hoofnagle, A. N., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012030223 · Cited by 542 · see citing works
Self-citationClinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia
Haffner, D., Emma, F., Eastwood, D. M., Duplan, M. B., Bacchetta, J., Schnabel, D., Wicart, P., Böckenhauer, D., Santos, F., Levtchenko, E. N., et al. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0152-5 · Cited by 526 · see citing works
Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production
David, V., Martin, A., Isakova, T., Spaulding, C., Qi, L., Ramirez, V., Zumbrennen‐Bullough, K. B., Sun, C. C., Lin, H. Y.-F., Babitt, J. L., et al. (2015) · Kidney International · doi:10.1038/ki.2015.290 · Cited by 495 · see citing works
Self-citationZoccali, C., Vanholder, R. C., Massy, Z. A., Ortíz, A., Sarafidis, P. A., Dekker, F. W., Fliser, D., Fouque, D. P., Heine, G. H., Jager, K. J., et al. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.52 · Cited by 464 · see citing works
Fibroblast Growth Factor-23 and Cardiovascular Events in CKD
Scialla, J. J., Xie, H., Rahman, M., Anderson, A. H., Isakova, T., OJO, A. O., Zhang, X., Nessel, L. C., Hamano, T., Grunwald, J. E., et al. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013050465 · Cited by 443 · see citing works
Self-citationTherapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
Degirolamo, C., Sabbà, C., & Moschetta, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.9 · Cited by 424 · see citing works
Shalhoub, V., Shatzen, E. M., Ward, S. C., Davis, J., Stevens, J. L., Bi, V., Renshaw, L., Hawkins, N., Wang, W., Chen, C., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61405 · Cited by 417 · see citing works
Update on fibroblast growth factor 23 in chronic kidney disease
Wolf, M. S. (2012) · Kidney International · doi:10.1038/ki.2012.176 · Cited by 392 · see citing works
Self-citationFibrosis in Chronic Kidney Disease: Pathogenesis and Consequences
Panizo, S., Martínez‐Arias, L., Alonso‐Montes, C., Cannata, P., Martín-Carro, B., Martín, J. L. F., Naves‐Díaz, M., Carrillo‐López, N., & Cannata-Andía, J. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010408 · Cited by 375 · see citing works
Isakova, T., Nickolas, T. L., Denburg, M., Yarlagadda, S. G., Weiner, D. E., Gutiérrez, O. M., Bansal, V., Rosas, S. E., Nigwekar, S. U., Yee, J., et al. (2017) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2017.07.019 · Cited by 374 · see citing works
Self-citationLim, Y. J., Sidor, N. A., Tonial, N. C., Che, A., & Urquhart, B. L. (2021) · Toxins · doi:10.3390/toxins13020142 · Cited by 381 · see citing works
Zoccali, C., Mallamaci, F., Adamczak, M., de Oliveira, R. B., Massy, Z. A., Sarafidis, P. A., Agarwal, R., Mark, P. B., Kotanko, P., Ferro, C. J., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad083 · Cited by 385 · see citing works
Singh, S., Grabner, A., Yanucil, C., Schramm, K. J., Czaya, B. A., Krick, S., Czaja, M. J., Bartz, R., Abraham, R., Marco, G. S. D., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.05.019 · Cited by 361 · see citing works
Self-citationBone and muscle: Interactions beyond mechanical
Brotto, M. A. P., & Bonewald, L. F. (2015) · Bone · doi:10.1016/j.bone.2015.02.010 · Cited by 347 · see citing works
The Effects of High-Protein Diets on Kidney Health and Longevity
Ko, G.-J., Rhee, C. M., Kalantar-Zadeh, K., & Joshi, S. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020010028 · Cited by 345 · see citing works
Ebeling, P. R., Nguyen, H. H., Aleksova, J., Vincent, A. J., Wong, P., & Milat, F. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab028 · Cited by 354 · see citing works
Arterial calcification and bone physiology: role of the bone–vascular axis
Thompson, B., & Towler, D. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.36 · Cited by 336 · see citing works
Fibroblast growth factor 23 is not associated with and does not induce arterial calcification
Scialla, J. J., Lau, W. L., Reilly, M. P., Isakova, T., Yang, H.-Y. L., Crouthamel, M. H., Chavkin, N. W., Rahman, M., WAHL, P. W., Amaral, A. P., et al. (2013) · Kidney International · doi:10.1038/ki.2013.3 · Cited by 333 · see citing works
Self-citationTherapeutic management of hypophosphatemic rickets from infancy to adulthood
Linglart, A., Biosse-Duplan, M., Briot, K., Chaussain, C., Esterle, L., Guillaume-Czitrom, S., Kamenicky, P., Nevoux, J., Prié, D., Rothenbuhler, A., et al. (2014) · Endocrine Connections · doi:10.1530/ec-13-0103 · Cited by 331 · see citing works
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
Xie, J., Cha, S., An, S.-W., Kuro‐o, M., Birnbaumer, L., & Huang, C.-L. (2012) · Nature Communications · doi:10.1038/ncomms2240 · Cited by 330 · see citing works
Self-citationIx, J. H., Katz, R., Kestenbaum, B. R., de Boer, I. H., Chonchol, M., Mukamal, K. J., Rifkin, D. E., Siscovick, D. S., Sarnak, M. J., & Shlipak, M. G. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.03.040 · Cited by 325 · see citing works
FGF23 regulates renal sodium handling and blood pressure
Andrukhova, O., Slavić, S., Тихоновна, С. А., Zeitz, U., Shalhoub, V., Lanske, B., Pohl, E. E., & Erben, R. G. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303716 · Cited by 321 · see citing works
Block, G. A., Bushinsky, D. A., Cheng, S., Cunningham, J., Dehmel, B., Drüeke, T. B., Ketteler, M., Kewalramani, R., Martin, K. J., Moe, S. M., et al. (2017) · JAMA · doi:10.1001/jama.2016.19468 · Cited by 319 · see citing works
Associations between Kidney Function and Subclinical Cardiac Abnormalities in CKD
Park, M., Hsu, C., Li, Y., Mishra, R., Keane, M. G., Rosas, S. E., Dries, D. L., Xie, D., Chen, J., He, J., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012020145 · Cited by 318 · see citing works
Self-citationVascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho
Yamada, S., & Giachelli, C. M. (2016) · Bone · doi:10.1016/j.bone.2016.11.012 · Cited by 318 · see citing works
Cinacalcet, Fibroblast Growth Factor-23, and Cardiovascular Disease in Hemodialysis
Moe, S. M., Chertow, G. M., Parfrey, P. S., Kubo, Y., Block, G. A., Correa‐Rotter, R., Drüeke, T. B., Herzog, C. A., London, G. M., Mahaffey, K. W., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013876 · Cited by 305 · see citing works
Chronic Kidney Disease: A Clinical Model of Premature Aging
Stenvinkel, P., & Larsson, T. E. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.11.051 · Cited by 298 · see citing works
Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models
Su, N. Y., Jin, M. Y., & Chen, L. (2014) · Bone Research · doi:10.1038/boneres.2014.3 · Cited by 291 · see citing works
Endothelial Dysfunction in Chronic Kidney Disease, from Biology to Clinical Outcomes: A 2020 Update
Roumeliotis, S. K., Mallamaci, F., & Zoccali, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082359 · Cited by 295 · see citing works
FGF23 and its role in X-linked hypophosphatemia-related morbidity
Beck‐Nielsen, S. S., Zulf Mughal, M., Haffner, D., Nilsson, O., Levtchenko, E. N., Ariceta, G., Collantes, C. D. L., Schnabel, D., Jandhyala, R., & Mäkitie, O. (2019) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-019-1014-8 · Cited by 288 · see citing works
Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling
Hu, M. C., Shi, M., Cho, H. J., ADAMS-HUET, B. A., Paek, J., Hill, K., Shelton, J. M., Amaral, A. P., Faul, C., Taniguchi, M., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014050465 · Cited by 278 · see citing works
Self-citationFGF23 signaling impairs neutrophil recruitment and host defense during CKD
Rossaint, J., Oehmichen, J., Aken, H. V., Reuter, S., Pavenstädt, H. J., Meersch, M., Unruh, M. L., & Zarbock, A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83470 · Cited by 277 · see citing works
Self-citationFibroblast Growth Factor 23 and Inflammation in CKD
Mendoza, J. M., Isakova, T., Ricardo, A. C., Xie, H., Navaneethan, S. D., Anderson, A. H., Bazzano, L., Xie, D., Kretzler, M., Nessel, L. C., et al. (2012) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.13281211 · Cited by 270 · see citing works
Self-citationLau, W. L., Leaf, E. M., Hu, M. C., Takeno, M. M., Kuro‐o, M., Moe, O. W., & Giachelli, C. M. (2012) · Kidney International · doi:10.1038/ki.2012.322 · Cited by 266 · see citing works
Self-citationHu, M. C., Shi, M., Gillings, N., Flores, B., Takahashi, M., Kuro‐o, M., & Moe, O. W. (2017) · Kidney International · doi:10.1016/j.kint.2016.10.034 · Cited by 264 · see citing works
Self-citationXie, J., Yoon, J., An, S.-W., Kuro‐o, M., & Huang, C.-L. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014040325 · Cited by 263 · see citing works
Self-citationHigh dietary phosphorus intake is associated with all-cause mortality: results from NHANES III
Chang, A. R., Lazo, M., Appel, L. J., Gutiérrez, O. M., & Grams, M. E. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.073148 · Cited by 262 · see citing works
Self-citationMichaëlsson, K., Melhus, H., Lemming, E. W., Wolk, A., & Byberg, L. (2013) · BMJ · doi:10.1136/bmj.f228 · Cited by 260 · see citing works
Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism
Kuro‐o, M. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.111 · Cited by 254 · see citing works
Self-citationThe role of phosphate in kidney disease
on behalf of the ERA–EDTA Working Group on Chronic Kidney Disease–Mineral and Bone Disorders and the European Renal Nutrition Working Group, Vervloet, M. G., Sezer, S., Massy, Z. A., Johansson, L., Cozzolino, M. G., & Fouque, D. P. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.164 · Cited by 252 · see citing works
Vascular calcification: from pathophysiology to biomarkers
Evrard, S., Delanaye, P., Kamel, S., Cristol, J., Cavalier, E., Arnaud, J., Zaoui, P., Carlier, M.-C., Laville, M., Fouque, D. P., et al. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.08.034 · Cited by 244 · see citing works
Left Ventricular Hypertrophy in Chronic Kidney Disease Patients: From Pathophysiology to Treatment
Lullo, L. D., Gorini, A., Russo, D., Santoboni, A., & Ronco, C. (2015) · Cardiorenal Medicine · doi:10.1159/000435838 · Cited by 235 · see citing works
Interactions Between Muscle Tissues and Bone Metabolism
Kawao, N., & Kaji, H. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25040 · Cited by 231 · see citing works
Andrukhova, O., Zeitz, U., Goetz, R. M., Mohammadi, M., Lanske, B., & Erben, R. G. (2012) · Bone · doi:10.1016/j.bone.2012.05.015 · Cited by 228 · see citing works
Klotho and Chronic Kidney Disease
Hu, M. C., Kuro‐o, M., & Moe, O. W. (2013) · Contributions to nephrology · doi:10.1159/000346778 · Cited by 227 · see citing works
Self-citationGenetic insights into the mechanisms of Fgf signalingPreprint
Brewer, J. R., Mazot, P., & Soriano, P. M. (2016) · Genes & Development · doi:10.1101/gad.277137.115 · Cited by 224 · see citing works
Klotho/FGF23 Axis in Chronic Kidney Disease and Cardiovascular Disease
Lü, X., & Hu, M. C. (2016) · Kidney Diseases · doi:10.1159/000452880 · Cited by 220 · see citing works
Self-citationChirinos, J. A., Orlenko, A., Zhao, L., Basso, M., Cvijic, M. E., Li, Z., Spires, T. E., Yarde, M., Wang, Z., Seiffert, D., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.069 · Cited by 218 · see citing works
The chronic kidney disease — Mineral bone disorder (CKD-MBD): Advances in pathophysiology
Hruska, K. A., Sugatani, T., Agapova, O. A., & Fang, Y. (2017) · Bone · doi:10.1016/j.bone.2017.01.023 · Cited by 215 · see citing works
Babitt, J. L., Eisenga, M. F., Haase, V. H., Kshirsagar, A. V., Levin, A., Locatelli, F., Małyszko, J., Swinkels, D. W., Tarng, D., Cheung, M., et al. (2021) · Kidney International · doi:10.1016/j.kint.2021.03.020 · Cited by 222 · see citing works
Self-citationEpidemiology and Mechanisms of Uremia-Related Cardiovascular Disease
Tonelli, M. A., Karumanchi, S. A., & Thadhani, R. (2016) · Circulation · doi:10.1161/circulationaha.115.018713 · Cited by 214 · see citing works
Circulating fibroblast growth factors as metabolic regulators--a critical appraisal.
Angelin, B., Larsson, T., & Rudling, M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.001 · Cited by 210 · see citing works
Cardiovascular disease in chronic kidney disease: untying the Gordian knot
Hajhosseiny, R., Khavandi, K., & Goldsmith, D. J. A. (2012) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2012.02954.x · Cited by 207 · see citing works
Therapeutics Targeting FGF Signaling Network in Human Diseases
Katoh, M. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.10.003 · Cited by 206 · see citing works
New Insights into the Mechanism of Action of Soluble Klotho
Dalton, G. D., Xie, J., An, S.-W., & Huang, C. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00323 · Cited by 210 · see citing works
FGF23 Actions on Target Tissues—With and Without Klotho
Richter, B., & Faul, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00189 · Cited by 205 · see citing works
Self-citationElectrolyte and Acid-Base Disorders in Chronic Kidney Disease and End-Stage Kidney Failure
Dhondup, T., & Qian, Q. (2017) · Blood Purification · doi:10.1159/000452725 · Cited by 202 · see citing works
Leifheit‐Nestler, M., Siemer, R. G., Flasbart, K., Richter, B., Kirchhoff, F., Ziegler, W. H., Klintschar, M., Becker, J. U., Erbersdobler, A., Aufricht, C., et al. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv421 · Cited by 200 · see citing works
Self-citationCoupling fibroblast growth factor 23 production and cleavage
Wolf, M. S., & White, K. E. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000447020.74593.6f · Cited by 198 · see citing works
Self-citationKomaba, H., Taniguchi, M., Wada, A., Iseki, K., Tsubakihara, Y., & Fukagawa, M. (2015) · Kidney International · doi:10.1038/ki.2015.72 · Cited by 197 · see citing works
Marthi, A., Donovan, K., Haynes, R., Wheeler, D. C., Baigent, C., Rooney, C. M., Landray, M., Moe, S. M., Yang, J. M., Holland, L., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017121334 · Cited by 194 · see citing works
Cardiorenal syndrome: pathophysiology and potential targets for clinical management
Hatamizadeh, P., Fonarow, G. C., Budoff, M. J., Darabian, S., Kovesdy, C. P., & Kalantar‐Zadeh, K. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.279 · Cited by 195 · see citing works
Dai, B., David, V., Martin, A., Huang, J., Li, H., Jiao, Y., Gu, W., & Quarles, L. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044161 · Cited by 195 · see citing works
Touchberry, C., Green, T. M., Tchikrizov, V., Mannix, J., Mao, T. F., Carney, B. W., Girgis, M., Vincent, R. J., Wetmore, L. A., Dawn, B., et al. (2013) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00596.2012 · Cited by 195 · see citing works
Roles of phosphate and fibroblast growth factor 23 in cardiovascular disease
Scialla, J. J., & Wolf, M. S. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.49 · Cited by 194 · see citing works
Self-citationBacchetta, J., Sea, J. L., Chun, R. F., Lisse, T. S., Wesseling‐Perry, K., Gales, B., Adams, J. S., Salusky, I. B., & Hewison, M. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1740 · Cited by 190 · see citing works
Pathophysiology of calcium, phosphorus, and magnesium dysregulation in chronic kidney disease
Felsenfeld, A. J., Levine, B. S., & Rodriguez, M. (2015) · Seminars in Dialysis · doi:10.1111/sdi.12411 · Cited by 189 · see citing works
Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy
Yang, K., Wang, C., Nie, L., Zhao, X., Gu, J., Guan, X., Wang, S., Xiao, T., Xu, X., He, T., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014060543 · Cited by 189 · see citing works
Jimbo, R., Kawakami-Mori, F., Mu, S., Hirohama, D., Majtan, B., Shimizu, Y., Yatomi, Y., Fukumoto, S., Fujita, T., & Shimosawa, T. (2013) · Kidney International · doi:10.1038/ki.2013.332 · Cited by 189 · see citing works
Silswal, N., Touchberry, C. D., Daniel, D., McCarthy, D. L., Zhang, S., Andresen, J. J., Stubbs, J. R., & Wacker, M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00264.2014 · Cited by 189 · see citing works
Lekawanvijit, S., Kompa, A. R., Wang, B. H., Kelly, D. J., & Krum, H. (2012) · Circulation Research · doi:10.1161/circresaha.112.278457 · Cited by 183 · see citing works
Lutsey, P. L., Alonso, Á., Michos, E. D., Loehr, L. R., Astor, B. C., Coresh, J., & Folsom, A. R. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.085167 · Cited by 181 · see citing works
Neyra, J. A., Hu, M. C., & Moe, O. W. (2020) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02840320 · Cited by 184 · see citing works
Self-citationFGF23 signalling and physiology
Ho, B. B., & Bergwitz, C. (2021) · Journal of Molecular Endocrinology · doi:10.1530/jme-20-0178 · Cited by 180 · see citing works
Kumar, U., Wettersten, N. W., & Garimella, P. S. (2019) · Cardiology Clinics · doi:10.1016/j.ccl.2019.04.001 · Cited by 193 · see citing works
Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging
Serna, J., & Bergwitz, C. (2020) · Nutrients · doi:10.3390/nu12103001 · Cited by 190 · see citing works
CKD-Induced Wingless/Integration1 Inhibitors and Phosphorus Cause the CKD–Mineral and Bone Disorder
Fang, Y., Ginsberg, C., Seifert, M. E., Agapova, O. A., Sugatani, T., Register, T. C., Freedman, B. I., Monier‐Faugere, M., Malluche, H. H., & Hruska, K. A. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013080818 · Cited by 173 · see citing works
Renal and Extrarenal Actions of Klotho
Hu, M. C., Kuro‐o, M., & Moe, O. W. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.12.013 · Cited by 172 · see citing works
Self-citationFGF23-Klotho signaling axis in the kidney
Erben, R. G., & Andrukhova, O. (2016) · Bone · doi:10.1016/j.bone.2016.09.010 · Cited by 168 · see citing works
Kuro-o, M. (2012) · Current opinion in nephrology and hypertension · doi:10.1097/mnh.0b013e32835422ad · Cited by 175 · see citing works
Self-citationMuscle‐bone crosstalk and potential therapies for sarco‐osteoporosis
Li, G., Zhang, L., Wang, D., AIQudsy, L., Jiang, J. X., Xu, H., & Shang, P. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28946 · Cited by 166 · see citing works
Physiological Actions of Fibroblast Growth Factor-23
Erben, R. G. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00267 · Cited by 166 · see citing works
Covic, A. C., Vervloet, M. G., Massy, Z. A., Ureña, P., Goldsmith, D. J. A., Brandenburg, V. M., Mazzaferro, S., Evenepoel, P., Bover, J., Apetrii, M., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30310-8 · Cited by 164 · see citing works
Olauson, H., Lindberg, K., Amin, R., Sato, T., Jia, T., Goetz, R. M., Mohammadi, M., Andersson, G., Lanske, B., & Larsson, T. E. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003975 · Cited by 163 · see citing works
Evolving concepts in the pathogenesis of uraemic cardiomyopathy
Wang, X., & Shapiro, J. I. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0101-8 · Cited by 165 · see citing works
Disordered FGF23 and Mineral Metabolism in Children with CKD
Portale, A. A., Wolf, M. S., Jüppner, H., Messinger, S., Kumar, J., Wesseling‐Perry, K., Schwartz, G. J., Furth, S. L., Warady, B. A., & Salusky, I. B. (2013) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05840513 · Cited by 161 · see citing works
Self-citationBlock, G. A., Bushinsky, D. A., Cunningham, J., Drüeke, T. B., Ketteler, M., Kewalramani, R., Martin, K. J., Mix, T.-C. H., Moe, S. M., Patel, U. D., et al. (2017) · JAMA · doi:10.1001/jama.2016.19456 · Cited by 161 · see citing works
Lee, J., Jeng, Y., Su, S.-Y., Wu, C., Tsai, K., Lee, C., Lin, C., Carter, J. M., Huang, J., Chen, S., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4465 · Cited by 160 · see citing works
Acute Kidney Injury and Risk of Heart Failure and Atherosclerotic Events
Go, A. S., Hsu, C., Yang, J., Tan, T. C., Zheng, S., Ordoñez, J. D., & Liu, K. D. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12591117 · Cited by 159 · see citing works
Self-citation
- Authors
- Faul, C., Amaral, A. P., Oskouei, B., Hu, M.-C., Sloan, A., Isakova, T., Gutiérrez, O. M., Aguillon-Prada, R., Lincoln, J., Hare, J. M., Mundel, P., Morales, A., Scialla, J., Fischer, M., Soliman, E. Z., Chen, J., Go, A. S., Rosas, S. E., Nessel, L., Townsend, R. R., Feldman, H. I., St. John Sutton, M., Ojo, A., Gadegbeku, C., Di Marco, G. S., Reuter, S., Kentrup, D., Tiemann, K., Brand, M., Hill, J. A., Moe, O. W., Kuro-o, M., Kusek, J. W., Keane, M. G., & Wolf, M.
- Affiliations
- University of Miami (US)
- The University of Texas Southwestern Medical Center (US)
- University of Alabama at Birmingham (US)
- Harvard University (US)
- University of Illinois Chicago (US)
- Wake Forest University (US)
- Tulane University (US)
- University of California, San Francisco (US)
- University of Pennsylvania (US)
- University of Michigan (US)
- Temple University (US)
- University of Münster (DE)
- National Institutes of Health (US)
- ORCID
- Faul, Christian
- Amaral, Ansel P.
- Isakova, Tamara
- Gutiérrez, Orlando M.
- Lincoln, Joy
- Hare, Joshua M.
- Mundel, Peter
- Scialla, Julia
- Fischer, Michael
- Soliman, Elsayed Z.
- Chen, Jing
- Go, Alan S.
- Rosas, Sylvia E.
- Townsend, Raymond R.
- Feldman, Harold I.
- Ojo, Akinlolu
- Reuter, Stefan
- Kentrup, Dominik
- Tiemann, Klaus
- Hill, Joseph A.
- Moe, Orson W.
- Keane, Martin G.
- Wolf, Myles
- Venue
- Journal of Clinical Investigation
- Published
- 2011-11-01
- Volume
- 121
- Issue
- 11
- Pages
- 4393-4408
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3204831
- OpenAlex
- W2015668150
- Cited by
- 2,027
- References
- 92
- Citations by year
- 2026: 83 · 2025: 92 · 2024: 81 · 2023: 124 · 2022: 135 · 2021: 172 · 2020: 126 · 2019: 144 · 2018: 175 · 2017: 152 · 2016: 154 · 2015: 152 · 2014: 170 · 2013: 155 · 2012: 104
- FWCI
- 107.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- American Heart Association
- Abbott Laboratories
- Amgen
- Nephcure Foundation
- University of Miami
- University of Pennsylvania
- Health Services Research and Development
- Cleveland Clinic
- Cleveland Clinic Foundation
- Johns Hopkins University (RR025005)
- University of Texas Southwestern Medical Center
- Case Western Reserve University (UL1RR024989)
- Deutsches Krebsforschungszentrum
- Ministry of Education, India
- Stifterverband
- National Institutes of Health (RR024131, RR025005, RR05096, RR024989)
- University of Illinois at Urbana-Champaign
- University of California, San Francisco
- Leonard M. Miller School of Medicine
- National Institute on Aging (R01AG019712)
- National Institute of Diabetes and Digestive and Kidney Diseases (5U01DK06102, R01DK076116, K24DK062234, U01DK060990, 5U01 DK60980, (P30-DK-07938, R01DK081374, R01DK062472, F30DK091057, K23DK081673, K23DK087858, R01DK091392, RR024986, R01DK091218, R01DK092461, U01DK060984, U01DK060902, U01DK060980, U01DK060963, U01DK061021, U01DK061028)
- National Center for Research Resources (UL1RR024131, RR-05096, UL1RR024989, UL1RR025005, RR 024131, M01RR016500, UL1RR024986, UL1RR024134, UL1RR029879, M01RR005096, M01RR 16500, M01RR000042)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- fibroblast growth factor 23, left ventricular hypertrophy, chronic kidney disease, calcineurin/NFAT signaling, fibroblast growth factor receptor, cardiomyocyte hypertrophy, cardiovascular disease
- MeSH terms
- Fibroblast Growth Factor-23, Klotho Proteins, Adult, Aged, Animals, Disease Models, Animal, Female, Fibroblast Growth Factors, Glucuronidase, Humans, Kidney Failure, Chronic, Male, Mice, Inbred C57BL, Middle Aged, Models, Cardiovascular, Prospective Studies, Recombinant Proteins, Cohort Studies, Signal Transduction, Fibroblast Growth Factor 2, Hypertrophy, Left Ventricular, Receptors, Fibroblast Growth Factor, Mice, Knockout, Myocytes, Cardiac, Mice, Rats, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review