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Basic and Clinical Concepts Related to Vitamin D Metabolism and Action: (First of Two Parts)
Abstract
A NOVEL sterol hormone that is undoubtedly a major physiologic regulator of mineral metabolism in man, 1α,25-dihydroxyvitamin D (1,25(OH)2D), is produced from vitamin D in response to situations of calcium and phosphorus need, with the final enzymatic reaction occurring in the kidney. A complex and elegant biochemical mechanism is thought to function at the pivotal kidney site to modulate the biosynthesis of this most active form of vitamin D. In concert with other calcitropic principles, such as parathyroid hormone (PTH) and calcitonin, the 1,25-(OH)2D hormone mediates calcium and phosphorus metabolism at target tissues, including . . .
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Cited by
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783
Vitamin D Deficiency Inhibits Pancreatic Secretion of Insulin
Norman, A. W., Frankel, B. J., Heldt, A. M., & Grodsky, G. M. (1980) · Science · doi:10.1126/science.6250216 · Cited by 720
Vitamin D, disease and therapeutic opportunities
Plum, L. A., & DeLuca, H. F. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3318 · Cited by 477
The Cutaneous Photosynthesis of Previtamin D3: A Unique Photoendocrine System
Holick, M. F. (1981) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12479237 · Cited by 379
Nordin, B. E. C. (1997) · Nutrition · doi:10.1016/s0899-9007(97)83011-0 · Cited by 367
Metadata
- Authors
- Haussler, M. R., & McCain, T. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-11-03
- Volume
- 297
- Issue
- 18
- Pages
- 974-983
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1988159250
- Cited by
- 575
- References
- 0
- FWCI
- 53.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haussler, M. R., & McCain, T. A. (1977). Basic and Clinical Concepts Related to Vitamin D Metabolism and Action: (First of Two Parts). New England Journal of Medicine. https://doi.org/10.1056/nejm197711032971804
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
