The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Vitamin D Deficiency Inhibits Pancreatic Secretion of Insulin
Abstract
The effect of a vitamin D deficiency on insulin and glucagon release was determined in the isolated perfused rat pancreas by radioimmunoassay of the secreted proteins. During a 30-minute period of perfusion with glucose and arginine, pancreases from vitamin D-deficient rats exhibited a 48 percent reduction in insulin secretion compared to that for pancreases from vitamin D-deficient rats that had been replenished with vitamin D. Vitamin D status had no effect on pancreatic glucagon secretion. This result, along with the previously demonstrated presence in the pancreas of a vitamin D-dependent calcium-binding protein and cytosol receptor for the hormonal form of vitamin D, 1,25-dihydroxyvitamin D 3 , indicates an important role for vitamin D in the endocrine functioning of the pancreas.
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Citations
Cites
Metabolism and Mechanism of Action of Vitamin D
DeLuca, H. F., & Schnoes, H. K. (1976) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.45.070176.003215 · Cited by 657
Dynamics of Insulin Secretion by the Perfused Rat Pancreas
CURRY, D. L., BENNETT, L. L., & GRODSKY, G. M. (1968) · Endocrinology · doi:10.1210/endo-83-3-572 · Cited by 601
Self-citationBasic and Clinical Concepts Related to Vitamin D Metabolism and Action: (First of Two Parts)
Haussler, M. R., & McCain, T. A. (1977) · New England Journal of Medicine · doi:10.1056/nejm197711032971804 · Cited by 575
Effects of Diabetes Mellitus on Bone Mass in Juvenile and Adult-Onset Diabetes
Levin, M. E., Boisseau, V. C., & Avioli, L. V. (1976) · New England Journal of Medicine · doi:10.1056/nejm197601292940502 · Cited by 519
AN IMMUNOCHEMICAL ASSAY OF TOTAL EXTRACTABLE INSULIN IN MAN *
Grodsky, G. M., & Forsham, P. H. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104122 · Cited by 362
Self-citation1α,25-Dihydroxycholecalciferol Receptors in Intestine
Brumbaugh, P. F., & Haussler, M. R. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42968-2 · Cited by 278
Basic and Clinical Concepts Related to Vitamin D Metabolism and Action: (Second of Two Parts)
Haussler, M. R., & McCain, T. A. (1977) · New England Journal of Medicine · doi:10.1056/nejm197711102971906 · Cited by 254
A Specific High-Affinity Binding Macromolecule for 1,25-Dihydroxyvitamin D 3 in Fetal Bone
Kream, B. E., Jose, M., Yamada, S., & DeLuca, H. F. (1977) · Science · doi:10.1126/science.887939 · Cited by 245
Gerich, J. E., Charles, M. A., & Grodsky, G. M. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107823 · Cited by 230
Self-citationCHRISTAKOS, S., FRIEDLANDER, E. J., FRANDSEN, B. R., & NORMAN, A. W. (1979) · Endocrinology · doi:10.1210/endo-104-5-1495 · Cited by 224
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Cited by
Vitamin D metabolism, mechanism of action, and clinical applications
Bikle, D. D. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.12.016 · Cited by 1,933
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783
Hypovitaminosis D is associated with insulin resistance and β cell dysfunction
Chiu, K. C., Chu, A., Go, V. L. W., & Saad, M. F. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.820 · Cited by 1,642
Norman, A. W. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.491s · Cited by 1,090
Self-citationScragg, R., Sowers, M., & Bell, C. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2813 · Cited by 963
Metadata
- Authors
- Norman, A. W., Frankel, B. J., Heldt, A. M., & Grodsky, G. M.
- Venue
- Science
- Published
- 1980-08-15
- Volume
- 209
- Issue
- 4458
- Pages
- 823-825
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1991736636
- Cited by
- 720
- References
- 23
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Norman, A. W., Frankel, B. J., Heldt, A. M., & Grodsky, G. M. (1980). Vitamin D Deficiency Inhibits Pancreatic Secretion of Insulin. Science. https://doi.org/10.1126/science.6250216
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
