The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reconstitution in Severe Combined Immunodeficiency by Transplantation of Marrow from an Unrelated Donor
Abstract
A patient with severe combined immunodeficiency received seven transplants of bone marrow from an HLA-B-compatible and HLA-D-compatible unrelated donor in an attempt to provide immunologic reconstitution. The first four transplants achieved restricted engraftment with evidence of rudimentary immunologic function. A fifth transplant, given after low-dose cyclophosphamide, produced reconstituion of cell-mediated immunity. Marrow aplasia developed after recontamination with a nonpathogenic microflora. Transplantation of marrow previously stored in liquid nitrogen was ineffective. A subsequent transplant, administered after high-dose cyclophosphamide, achieved durable engraftment, with complete hematopoietic and immunologic reconstitution. Seventeen months after transplantation, full functional engraftment persists. Graft-versus-host disease has been chronic and moderately severe, but limited to the skin and oral mucosa. Transplantation of marrow from unrelated histocompatible donors may provide a useful treatment for patients with severe combined immunodeficiency or aplastic anemia who lack a matched sibling or related donor.
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Citations
Cites
IMMUNOLOGICAL RECONSTITUTION OF SEX-LINKED LYMPHOPENIC IMMUNOLOGICAL DEFICIENCY
Gatti, R., Meuwissen, H., Allen, H., Hong, R., & Good, R. (1968) · The Lancet · doi:10.1016/s0140-6736(68)92673-1 · Cited by 1,018
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Cited by
The Primary Immunodeficiencies
Rosen, F. S., Cooper, M. D., & Wedgwood, R. J. P. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408023110506 · Cited by 1,077
Armitage, J. O. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403243301206 · Cited by 601
A retrospective analysis of therapy for acute graft-versus-host disease: secondary treatment
Martin, P., Schoch, G., Fisher, L., Byers, V, Appelbaum, F., McDonald, G., Storb, R., & Hansen, J. (1991) · Blood · doi:10.1182/blood.v77.8.1821.1821 · Cited by 566
Self-citationA Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency
Hacein-Bey-Abina, S., Pai, S.-Y., Gaspar, H. B., Armant, M., Berry, C. C., Blanche, S., Bleesing, J., Blondeau, J., de Boer, H., Buckland, K. F., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1404588 · Cited by 412
Metadata
- Authors
- O'Reilly, R. J., Dupont, B., Pahwa, S., Grimes, E., Smithwick, E. M., Pahwa, R., Schwartz, S., Hansen, J. A., Siegal, F. P., Sorell, M., Svejgaard, A., Jersild, C., Thomsen, M., Platz, P., L'Esperance, P., & Good, R. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1977-12-15
- Volume
- 297
- Issue
- 24
- Pages
- 1311-1318
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1977422734
- Cited by
- 180
- References
- 1
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- O'Reilly, R. J., Dupont, B., Pahwa, S., Grimes, E., Smithwick, E. M., Pahwa, R., Schwartz, S., Hansen, J. A., Siegal, F. P., Sorell, M., Svejgaard, A., Jersild, C., Thomsen, M., Platz, P., L'Esperance, P., & Good, R. A. (1977). Reconstitution in Severe Combined Immunodeficiency by Transplantation of Marrow from an Unrelated Donor. New England Journal of Medicine. https://doi.org/10.1056/nejm197712152972403
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
