The DOI matches its Crossref record.
Circulating Immune Complexes in the Idiopathic Interstitial Pneumonias
Abstract
We determined circulating immune complex levels and their correlation with pulmonary histopathology, immunofluorescence and steroid responsiveness in 24 patients with idiopathic interstitial pneumonias. Levels were elevated in all but three of 16 patients with cellular disease, but in none of eight with diffuse fibrosis (P less than 0.001). Granular deposition of IgG, usually with elevated levels, but in only 11 per cent of those with normal levels (P less than 0.001). The radiographic and physiologic response to corticosteroid therapy was better in patients with initially elevated levels than in those with normal levels (P less than 0.03). Circulating immune complexex are present in patients with cellular idiopathic interstitial pneumonias, have a pathogentic role in this disease and may identify a patient population that is potentially steroid responsive.
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Citations
Cited by
Idiopathic Pulmonary Fibrosis: Clinical Relevance of Pathologic Classification
KATZENSTEIN, A.-L. A., & MYERS, J. L. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9707039 · Cited by 1,261
Cryptogenic fibrosing alveolitis: clinical features and their influence on survival
Turner-Warwick, M., Burrows, B., & Johnson, A. (1980) · Thorax · doi:10.1136/thx.35.3.171 · Cited by 508
Martinet, Y., Rom, W. N., Grotendorst, G. R., Martin, G. R., & Crystal, R. G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170404 · Cited by 414
A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.
Roths, J. B., Murphy, E. D., & Eicher, E. M. (1984) · The Journal of experimental medicine · doi:10.1084/jem.159.1.1 · Cited by 299
Circulating antibodies to lung protein(s) in patients with cryptogenic fibrosing alveolitis
Wallace, W. A., Roberts, S. N., Caldwell, H., Thornton, E., Greening, A. P., Lamb, D., & Howie, S. E. (1994) · Thorax · doi:10.1136/thx.49.3.218 · Cited by 52
Metadata
- Authors
- Dreisin, R. B., Schwarz, M. I., Theofilopoulos, A. N., & Stanford, R. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1978-02-16
- Volume
- 298
- Issue
- 7
- Pages
- 353-357
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2066367045
- Cited by
- 278
- References
- 0
- FWCI
- 47.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dreisin, R. B., Schwarz, M. I., Theofilopoulos, A. N., & Stanford, R. E. (1978). Circulating Immune Complexes in the Idiopathic Interstitial Pneumonias. New England Journal of Medicine. https://doi.org/10.1056/nejm197802162980701
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
