The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis
Abstract
Idiopathic pulmonary fibrosis is a fibrotic lung disease characterized by an increased number of mesenchymal cells in the alveolar walls. Alveolar macrophages constitutively express low levels of c-sis, the protooncogene coding for the B chain of platelet-derived growth factor, a protein with chemotactic and mitogenic activity toward mesenchymal cells. We therefore hypothesized that alveolar macrophages in patients with idiopathic pulmonary fibrosis may release increased amounts of platelet-derived growth factor, which might help to explain the accumulation of mesenchymal cells and the fibrosis of the lower respiratory tract in the disease. Evaluation of alveolar macrophages recovered from the lungs of patients with idiopathic pulmonary fibrosis demonstrated that these cells spontaneously released four times more platelet-derived growth factor than did alveolar macrophages recovered from normal persons (P less than 0.01). That the platelet-derived growth factor molecules were potentially active was shown by their chemotactic activity for smooth-muscle cells and their ability to act as a "competence" factor for fibroblast growth. These observations suggest the possibility that the accumulation of mesenchymal cells within the alveolar walls in patients with idiopathic pulmonary fibrosis may result partly from the exaggerated release of the potent mitogen platelet-derived growth factor by mononuclear phagocytes in the lower respiratory tract.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ross, R., Glomset, J., Kariya, B., & Harker, L. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.4.1207 · Cited by 1,847
LEUKOCYTE LOCOMOTION AND CHEMOTAXIS
Zigmond, S. H., & Hirsch, J. G. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.137.2.387 · Cited by 1,679
Waterfield, M. D., Scrace, G. T., Whittle, N., Stroobant, P., Johnsson, A., Wasteson, Å., Westermark, B., Heldin, C.-H., Huang, J. S., & Deuel, T. F. (1983) · Nature · doi:10.1038/304035a0 · Cited by 1,616
Doolittle, R. F., Hunkapiller, M. W., Hood, L. E., Devare, S. G., Robbins, K. C., Aaronson, S. A., & Antoniades, H. N. (1983) · Science · doi:10.1126/science.6304883 · Cited by 1,536
Yarden, Y., Escobedo, J. A., Kuang, W.-J., Yang-Feng, T. L., Daniel, T. O., Tremble, P. M., Chen, E. Y., Ando, M. E., Harkins, R. N., Francke, U., et al. (1986) · Nature · doi:10.1038/323226a0 · Cited by 1,209
Hunninghake, G. W., Gadek, J. E., Kawanami, O., Ferrans, V. J., & Crystal, R. G. (1979) · PubMed Central · Cited by 941
Self-citationDual control of cell growth by somatomedins and platelet-derived growth factor.
Stiles, C. D., Capone, G. T., Scher, C. D., Antoniades, H. N., Van Wyk, J. J., & Pledger, W. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.3.1279 · Cited by 909
Growth factors: Mechanism of action and relation to oncogenes
Heldin, C.-H., & Westermark, B. (1984) · Cell · doi:10.1016/0092-8674(84)90296-4 · Cited by 854
Platelet-derived growth factor in chemotactic for fibroblasts.
Seppä, H., Grotendorst, G., Seppä, S., Schiffmann, E., & Martin, G. R. (1982) · The Journal of cell biology · doi:10.1083/jcb.92.2.584 · Cited by 740
Self-citationA significant part of macrophage-derived growth factor consists of at least two forms of PDGF
Shimokado, K., Raines, E. W., Madtes, D. K., Barrett, T. B., Benditt, E. P., & Ross, R. (1985) · Cell · doi:10.1016/0092-8674(85)90033-9 · Cited by 715
Cited by
Macrophages: master regulators of inflammation and fibrosis
Wynn, T., & Barron, L. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255354 · Cited by 1,392
Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
Wollin, L., Wex, E., Pautsch, A., Schnapp, G., Hostettler, K. E., Stowasser, S., & Kolb, M. (2015) · European Respiratory Journal · doi:10.1183/09031936.00174914 · Cited by 1,005
Regulation of PDGF and its receptors in fibrotic diseases
Bonner, J. C. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.006 · Cited by 768
Therapy for Fibrotic Diseases: Nearing the Starting Line
Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655
Host Responses in Tissue Repair and Fibrosis
Duffield, J. S., Lupher, M., Thannickal, V. J., & Wynn, T. A. (2013) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-163930 · Cited by 624
Metadata
- Authors
- Martinet, Y., Rom, W. N., Grotendorst, G. R., Martin, G. R., & Crystal, R. G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-07-23
- Volume
- 317
- Issue
- 4
- Pages
- 202-209
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2012244701
- Cited by
- 414
- References
- 44
- FWCI
- 35.49
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis. https://app.cochat.ai/papers/10.1056/nejm198707233170404
- The paper
- Martinet, Y., Rom, W. N., Grotendorst, G. R., Martin, G. R., & Crystal, R. G. (1987). Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis. New England Journal of Medicine. https://doi.org/10.1056/nejm198707233170404
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
