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Molecular Basis of Proteinuria of Glomerular Origin
Abstract
THE process of urine formation begins at the walls of the glomerular capillaries with the separation of as much as a third of the plasma entering the glomeruli of each kidney into a solution having the properties of a nearly ideal ultrafiltrate. Driven by a hydraulic force created by the pumping action of the heart, ultrafiltrate flows across these capillary walls at an enormous rate, when considered in biologic terms, exceeding by at least two orders of magnitude that across other membranes studied thus far.1 Despite their extremely low intrinsic resistance to the flow of water, however, these same glomerular . . .
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Citations
Cited by
Normal and abnormal aspects of proteinuria
Lillehoj, E. P., & Poulik, M. D. (1986) · Experimental pathology · doi:10.1016/s0232-1513(86)80002-0 · Cited by 527
Current issues in measurement and reporting of urinary albumin excretion
Miller, W. G., Bruns, D. E., Hortin, G. L., Sandberg, S., Aakre, K. M., McQueen, M. J., Itoh, Y., Lieske, J. C., Seccombe, D. W., Jones, G., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.106567 · Cited by 381
Olson, J. L., Hostetter, T. H., Rennke, H. G., Brenner, B. M., & Venkatachalam, M. A. (1982) · Kidney International · doi:10.1038/ki.1982.143 · Cited by 353
Self-citationJha, R., Lopez-Trevino, S., Kankanamalage, H. R., & Jha, J. C. (2024) · Biomedicines · doi:10.3390/biomedicines12051098 · Cited by 144
Parthasarathy, N., & Spiro, R. G. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90809-4 · Cited by 99
Metadata
- Authors
- Brenner, B. M., Hostetter, T. H., & Humes, H. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1978-04-13
- Volume
- 298
- Issue
- 15
- Pages
- 826-833
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2086176947
- Cited by
- 446
- References
- 0
- FWCI
- 23.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brenner, B. M., Hostetter, T. H., & Humes, H. D. (1978). Molecular Basis of Proteinuria of Glomerular Origin. New England Journal of Medicine. https://doi.org/10.1056/nejm197804132981507
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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