The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
A Controlled Trial of Immunotherapy in Insect Hypersensitivity
Abstract
Insect hypersensitivity is currently treated by immunization using whole-body extracts. We compared this regimen with immunotherapy using insect venoms or placebo in groups of 20 patients matched for history and sensitivity, as judged by venom skin test, histamine release and IgE antibody to venom. After six to 10 weeks of immunization, systemic reactions to stings occurred in seven of 12, seven of 11, and one of 18 patients treated with placebo, whole-body extract, and venom, respectively. Placebo and whole-body extract gave similar results and were significantly less effective than venom immunotherapy (P less than 0.01). The 14 patients with failure of treatment with whole-body extract and placebo were subsequently provided with venom immunotherapy; one reacted to a subsequent sting. We conclude that venom immunotherapy is clinically superior to therapy on whole-body extract or placebo.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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Levine, B. B. (1966) · New England Journal of Medicine · doi:10.1056/nejm196611172752009 · Cited by 262
Norman, P. S., Winkenwerder, W. L., & Lichtenstein, L. M. (1968) · Journal of Allergy · doi:10.1016/0021-8707(68)90139-1 · Cited by 188
Self-citationSobotka, A. K., Franklin, R. M., Adkinson, N. F., Valentine, M. D., Baer, H., & Lichtenstein, L. M. (1976) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(76)90076-2 · Cited by 144
Self-citationGordon, J. E., Chitkara, I. D., & Wyon, J. B. (1963) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196303000-00022 · Cited by 144
Diagnosis of Allergy to Stinging Insects by Skin Testing with Hymenoptera Venoms
Hunt, K. J., VALENTINE, M. D., SOBOTKA, A. K., & LICHTENSTEIN, L. M. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-85-1-56 · Cited by 134
Self-citationFrequency of Hymenoptera allergy in an atopic and normal population
Settipane, G. A., Newstead, G. J., & Boyd, G. K. (1972) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(72)90045-0 · Cited by 133
Sobotka, A. K., Valentine, M. D., Benton, A. W., & Lichtenstein, L. M. (1974) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(74)90005-0 · Cited by 131
Self-citationPenicilloyl-Polylysine as an Intradermal Test of Penicillin Sensitivity
Brown, B. C., Price, E. V., & Moore, M. B. (1964) · JAMA · doi:10.1001/jama.1964.03070080005001 · Cited by 92
Immunotherapy in Bee-Sting Anaphylaxis: Use of Honeybee Venom
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Allergen immunotherapy: A practice parameter third update
Cox, L., Nelson, H., Lockey, R., Calabria, C., Chacko, T., Finegold, I., Nelson, M., Weber, R., Bernstein, D. I., Blessing-Moore, J., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.034 · Cited by 1,256
Allergy Diagnostic Testing: An Updated Practice Parameter
Bernstein, I. L., Li, J. T., Bernstein, D. I., Hamilton, R., Spector, S. L., Tan, R., Sicherer, S., Golden, D. B. K., Khan, D. A., Nicklas, R. A., et al. (2008) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)60305-5 · Cited by 723
Fatalities from immunotherapy (IT) and skin testing (ST)
Lockey, R. F., Benedict, L. M., Turkeltaub, P. C., & Bukantz, S. C. (1987) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(87)80164-1 · Cited by 570
Anaphylaxis—a practice parameter update 2015
Lieberman, P., Nicklas, R. A., Randolph, C., Oppenheimer, J., Bernstein, D., Bernstein, J., Ellis, A., Golden, D. B. K., Greenberger, P., Kemp, S., et al. (2015) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2015.07.019 · Cited by 474
Diagnosis of Hymenoptera venom allergy
Biló, B. M., Rueff, F., Mosbech, H., Bonifazi, F., Oude‐Elberink, J. N. G., & the EAACI Interest Group on Insect Venom Hypersensitivity (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00963.x · Cited by 444
Metadata
- Authors
- Hunt, K. J., Valentine, M. D., Sobotka, A. K., Benton, A. W., Amodio, F. J., & Lichtenstein, L. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1978-07-27
- Volume
- 299
- Issue
- 4
- Pages
- 157-161
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341810285
- Cited by
- 710
- References
- 10
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hunt, K. J., Valentine, M. D., Sobotka, A. K., Benton, A. W., Amodio, F. J., & Lichtenstein, L. M. (1978). A Controlled Trial of Immunotherapy in Insect Hypersensitivity. New England Journal of Medicine. https://doi.org/10.1056/nejm197807272990401
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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