The DOI matches its Crossref record.
Endometrial Cancer and Estrogen Use: Report of a Large Case-Control Study
Abstract
Our case-control study of the relation between estrogen use and endometrial cancer involved 451 cases and 888 controls. The overall risk of endometrial carcinoma was sixfold for estrogen users as compared with nonusers; long-term users (greater than five years) had a 15-fold risk. Excess risk was present for both diethylstilberstrol and conjugated estrogens. The risk associated with cyclic use was as great as that for continuous use. Increased risk was associated with estrogen use for all histologic grades of the tumor. The risk of advanced-stage carcinoma was fourfold for estrogen users, but rhe confidence interval was wide, and this question requires further study. Finally, this investigation contradicts the speculation that the association between this cancer and estrogen use can be explained by swifter diagnosis for estrogen users, misclassification of estrogen-related hyperplasia or treatment of early symptoms of the tumor with estrogen.
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Citations
Cited by
Hormone replacement therapy and endometrial cancer risk: A meta-analysis
GRADY, D., GEBRETSADIK, T., KERLIKOWSKE, K., ERNSTER, V, & PETITTI, D. (1995) · Obstetrics & Gynecology · doi:10.1016/0029-7844(94)00383-o · Cited by 962
Hip Fracture and the Use of Estrogens in Postmenopausal Women
Kiel, D. P., Felson, D. T., Anderson, J. J., Wilson, P. W. F., & Moskowitz, M. A. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711053171901 · Cited by 632
Adams, B. D., Furneaux, H., & White, B. A. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0022 · Cited by 478
Whitehead, M. I., Townsend, P. T., Pryse-Davies, J., Ryder, T. A., & King, R. J. B. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112313052701 · Cited by 396
Hormone replacement therapy in women with past history of endometriosis
Soliman, N. F., & Hillard, T. C. (2006) · Climacteric · doi:10.1080/13697130600868711 · Cited by 65
Metadata
- Authors
- Antunes, C. M. F., Stolley, P. D., Rosenshein, N. B., Davies, J. L., Tonascia, J. A., Brown, C., Burnett, L., Rutledge, A., Pokempner, M., & Garcia, R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1979-01-04
- Volume
- 300
- Issue
- 1
- Pages
- 9-13
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1987405808
- Cited by
- 388
- References
- 0
- FWCI
- 83.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Endometrial Cancer and Estrogen Use: Report of a Large Case-Control Study. https://app.cochat.ai/papers/10.1056/nejm197901043000103
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- Antunes, C. M. F., Stolley, P. D., Rosenshein, N. B., Davies, J. L., Tonascia, J. A., Brown, C., Burnett, L., Rutledge, A., Pokempner, M., & Garcia, R. (1979). Endometrial Cancer and Estrogen Use: Report of a Large Case-Control Study. New England Journal of Medicine. https://doi.org/10.1056/nejm197901043000103
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
