The DOI matches its Crossref record.
Prolonged Remissions of Cystic and Conglobate Acne with 13-cis-Retinoic Acid
Abstract
Fourteen patients with treatment-resistant cystic and conglobate acne were treated for four months with oral 13-cis-retinoic acid, a synthetic isomer of naturally occurring all-trans-retinoic acid. The average dose was 2.0 mg per kilogram per day. Thirteen patients experienced complete clearing of their disease; the other had 75 per cent improvement, as determined by the number of acne nodules and cysts present before and after therapy. Prolonged remissions, currently lasting as long as 20 months after discontinuation of therapy, have been observed in all 14 patients. Clinical toxicity was limited to the skin and mucous membranes in most patients and was dose dependent and rapidly reversible upon discontinuation of therapy. The mechanism of action of 13-cis-retinoic acid in the therapy of acne probably involves a direct inhibitory effect of the drug on the sebaceous gland.
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Citations
Cited by
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid
Breitman, T. R., Selonick, S. E., & Collins, S. J. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2936 · Cited by 1,966
Carazo, A., Macáková, K., Matoušová, K., Krčmová, L. K., Protti, M., & Mladěnka, P. (2021) · Nutrients · doi:10.3390/nu13051703 · Cited by 461
Essential fatty acids and acne
Downing, D. T., Stewart, M. E., Wertz, P. W., & Strauss, J. S. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70025-x · Cited by 263
Self-citationRadu, R. A., Mata, N. L., Nusinowitz, S., Liu, X., Sieving, P. A., & Travis, G. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737855100 · Cited by 227
Isotretinoin therapy for acne: results of a multicenter dose-response study
Strauss, J. S., Rapini, R. P., Shalita, A. R., Konecky, E., Pochi, P. E., Comite, H., & Exner, J. H. (1984) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(84)80100-0 · Cited by 223
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Metadata
- Authors
- Peck, G. L., Olsen, T. G., Yoder, F. W., Strauss, J. S., Downing, D. T., Pandya, M., Butkus, D., & Arnaud-Battandier, J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1979-02-15
- Volume
- 300
- Issue
- 7
- Pages
- 329-333
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2049647488
- Cited by
- 519
- References
- 0
- FWCI
- 60.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Prolonged Remissions of Cystic and Conglobate Acne with 13-cis-Retinoic Acid. https://app.cochat.ai/papers/10.1056/nejm197902153000701
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- Peck, G. L., Olsen, T. G., Yoder, F. W., Strauss, J. S., Downing, D. T., Pandya, M., Butkus, D., & Arnaud-Battandier, J. (1979). Prolonged Remissions of Cystic and Conglobate Acne with 13-cis-Retinoic Acid. New England Journal of Medicine. https://doi.org/10.1056/nejm197902153000701
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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