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Hypothalamic-Pituitary-Gonadal Dysfunction in Men Using Cimetidine
Abstract
We studied the effect of cimetidine therapy (1200 mg per day by mouth for nine weeks) on the hypothalamic-pituitary-gonadal axis of seven men. There was a 43 per cent mean reduction in sperm count after therapy. The luteinizing hormone response to luteinizing hormone releasing factor was also reduced, and a statistically significnat rise in plasma testosterone occurred, although it was less than that before therapy. Gonadotropin responses to provocative clomiphene stimulation were inadequate when compared with those of controls. Cimetidine did not affect the responses of thyroid-stimulating hormone, prolactin, growth hormone and thyroxine to thyrotropin releasing factor. Caution is advisable in administration of cimetidine for prolonged periods to young men.
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Cited by
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Semet, M., Paci, M., Saïas‐Magnan, J., Metzler‐Guillemain, C., Boissier, R., Lejeune, H., & Perrin, J. (2017) · Andrology · doi:10.1111/andr.12366 · Cited by 344
Adverse Reactions and Interactions with H2-Receptor Antagonists
Pension, J., & Wormsley, K. G. (1986) · Medical Toxicology · doi:10.1007/bf03259837 · Cited by 63
Metadata
- Authors
- Van Thiel, D. H., Gavaler, J. S., Smith, W. I., & Paul, G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1979-05-03
- Volume
- 300
- Issue
- 18
- Pages
- 1012-1015
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2327091559
- Cited by
- 182
- References
- 0
- FWCI
- 22.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hypothalamic-Pituitary-Gonadal Dysfunction in Men Using Cimetidine. https://app.cochat.ai/papers/10.1056/nejm197905033001803
- The paper
- Van Thiel, D. H., Gavaler, J. S., Smith, W. I., & Paul, G. (1979). Hypothalamic-Pituitary-Gonadal Dysfunction in Men Using Cimetidine. New England Journal of Medicine. https://doi.org/10.1056/nejm197905033001803
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
