The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Sustained Effectiveness of Converting-Enzyme Inhibition in Patients with Severe Congestive Heart Failure
Abstract
Eight patients with severe congestive heart failure refractory to conventional therapy, including vasodilators, were given captopril (seven patients) or teprotide (one patient). All had dyspnea, edema, elevated pulmonary wedge pressure (28.0 +/- 2.6 mm Hg), low cardiac index (1.6 +/- 0.1 liters per minute per square meter), and elevated levels of serum creatinine (2.3 +/- 0.2 mg per deciliter [203.3 +/- 17.7 mumol per liter]), blood urea nitrogen (48 +/- 5 mg per deciliter [17.1 +/- 1.8 mmol of urea per liter]), plasma renin activity (21 +/- 7 ng of angiotensin I per milliliter per hour), plasma angiotensin II (271 +/- 51 pg per milliliter), and plasma aldosterone (65 +/- 14 ng per deciliter). After one week of therapy, all indexes improved. Creatinine and p-aminohippurate clearances were also increased (P less than 0.01). Improvement was sustained (more than six months) and was associated with a statistically significant increase in the cardiac ejection fraction (12 +/- 3 to 26 +/- 7 per cent). With a mean follow-up of seven months, the New York Heart Association Functional Class has been reduced from IV to II, and the number of days of hospitalization to less than 10 per cent of that before captopril therapy. We conclude that captopril reduces afterload in advanced congestive heart failure and induces sustained improvements in clinical status and renal function.
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Citations
Cites
Vasodilator Therapy of Cardiac Failure: (First of Two Parts)
Cohn, J. N., & Franciosa, J. A. (1977) · New England Journal of Medicine · doi:10.1056/nejm197707072970105 · Cited by 481
Curtiss, C., Cohn, J. N., Vrobel, T., & Franciosa, J. A. (1978) · Circulation · doi:10.1161/01.cir.58.5.763 · Cited by 392
The renin-angiotensin-aldosterone system in congestive failure in conscious dogs.
Watkins, L., Burton, J. A., Haber, E., Cant, J. R., Smith, F. W., & Barger, A. C. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108431 · Cited by 302
Davis, R., Ribner, H. S., Keung, E., Sonnenblick, E. H., & LeJemtel, T. H. (1979) · New England Journal of Medicine · doi:10.1056/nejm197907193010301 · Cited by 272
Angiotensin converting enzyme inhibition in patients with congestive heart failure.
Gavras, H., Faxon, D. P., Berkoben, J., Brunner, H. R., & Ryan, T. J. (1978) · Circulation · doi:10.1161/01.cir.58.5.770 · Cited by 244
Packer, M., Meller, J., Gorlin, R., & Herman, M. V. (1979) · Circulation · doi:10.1161/01.cir.59.3.531 · Cited by 241
Underwood, R. H., & Williams, G. H. (1972) · PubMed · Cited by 216
Self-citationRENAL HEMODYNAMIC FACTORS IN CONGESTIVE HEART FAILURE*
Barger, A. C. (1966) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1966.tb41202.x · Cited by 191
Hollenberg, N. K., Williams, G. H., Burger, B., Ishikawa, I., & Adams, D. F. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108266 · Cited by 163
Self-citationConcentration of renin in renal venous blood in patients with chronic heart failure
Merrill, A. J., Morrison, J. L., & Brannon, E. S. (1946) · The American Journal of Medicine · doi:10.1016/0002-9343(46)90067-8 · Cited by 141
Cited by
Angiotensin-Converting Enzyme Inhibitors
Brown, N. J., & Vaughan, D. E. (1998) · Circulation · doi:10.1161/01.cir.97.14.1411 · Cited by 958
Pfeffer, M. A., Pfeffer, J. M., Steinberg, C., & Finn, P. (1985) · Circulation · doi:10.1161/01.cir.72.2.406 · Cited by 718
The Neurohumoral Axis in Congestive Heart Failure
FRANCIS, G. S., GOLDSMITH, S. R., LEVINE, T. B., OLIVARI, M. T., & COHN, J. N. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-3-370 · Cited by 600
Dzau, V. J., Packer, M., Lilly, L. S., Swartz, S. L., Hollenberg, N. K., & Williams, G. H. (1984) · New England Journal of Medicine · doi:10.1056/nejm198402093100603 · Cited by 428
Self-citationSchrier, R. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198810203191606 · Cited by 348
Metadata
- Authors
- Dzau, V. J., Colucci, W. S., Williams, G. H., Curfman, G., Meggs, L., & Hollenberg, N. K.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-06-19
- Volume
- 302
- Issue
- 25
- Pages
- 1373-1379
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1999022133
- Cited by
- 377
- References
- 18
- FWCI
- 34.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Sustained Effectiveness of Converting-Enzyme Inhibition in Patients with Severe Congestive Heart Failure. https://app.cochat.ai/papers/10.1056/nejm198006193022501
- The paper
- Dzau, V. J., Colucci, W. S., Williams, G. H., Curfman, G., Meggs, L., & Hollenberg, N. K. (1980). Sustained Effectiveness of Converting-Enzyme Inhibition in Patients with Severe Congestive Heart Failure. New England Journal of Medicine. https://doi.org/10.1056/nejm198006193022501
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
