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Angiotensin converting enzyme inhibition in patients with congestive heart failure.
Abstract
The etiology of afterload elevation in congestive cardiac failure is unclear, but experimental evidence suggests a role for the renin-angiotensin system in maintaining elevated peripheral vascular resistance. The angiotensin converting enzyme inhibitor SQ20,881 was administered to eight patients with congestive cardiac failure (four hypertensives, four normotensives) during or one day after diagnostic cardiac catheterization. Various hemodynamic measurements performed before and during blockade indicate that this agent caused improvement in cardiac function in all patients by decreasing afterload. This improvement correlated with the decrease in total vascular resistance but was independent of the baseline blood pressure and plasma renin activity. These results suggest that inhibition of angiotensin converting enzyme is a worthwhile approach to the treatment of congestive heart failure, although its exact mechanism of action remains unclear.
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Citations
Cited by
Angiotensin-Converting Enzyme Inhibitors
Brown, N. J., & Vaughan, D. E. (1998) · Circulation · doi:10.1161/01.cir.97.14.1411 · Cited by 958
The Neurohumoral Axis in Congestive Heart Failure
FRANCIS, G. S., GOLDSMITH, S. R., LEVINE, T. B., OLIVARI, M. T., & COHN, J. N. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-3-370 · Cited by 600
Dzau, V. J., Colucci, W. S., Williams, G. H., Curfman, G., Meggs, L., & Hollenberg, N. K. (1980) · New England Journal of Medicine · doi:10.1056/nejm198006193022501 · Cited by 377
Angiotensin 1–9 and 1–7 release in human heart role of cathepsin, A
Jackman, H. L., Massad, M. G., Sekosan, M., Tan, F., Brovkovych, V., Marcic, B. M., & Erdös, E. G. (2002) · Hypertension · doi:10.1161/01.hyp.0000017283.67962.02 · Cited by 110
How ACE inhibitors transformed the renin–angiotensin system
Bakhle, Y. S. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15045 · Cited by 41
Metadata
- Authors
- Gavras, H., Faxon, D. P., Berkoben, J., Brunner, H. R., & Ryan, T. J.
- Venue
- Circulation
- Published
- 1978-11
- Volume
- 58
- Issue
- 5
- Pages
- 770-776
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2072639812
- Cited by
- 244
- References
- 0
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gavras, H., Faxon, D. P., Berkoben, J., Brunner, H. R., & Ryan, T. J. (1978). Angiotensin converting enzyme inhibition in patients with congestive heart failure. Circulation. https://doi.org/10.1161/01.cir.58.5.770
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
