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Release of Inflammatory Mediators from Stimulated Neutrophils
Abstract
NEUTROPHILS of peripheral blood form the first line of defense against foreign substances introduced into the body by routes other than the digestive tract. As Metchnikoff observed in 1905, encounters between these professional phagocytes and foreign material invariably provoke inflammation:The mechanism by which the organism modifies these substances...is not as yet sufficiently known...But we know, very definitely, that each injection of serum, white of egg, milk, or fatty matter, is followed by a rather considerable aseptic inflammation at the point at which these substances are introduced. The organism digests the substances outside the gastrointestinal canal by means of an . . .
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Citations
Cited by
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Biological Responses to Materials
Anderson, J. M. (2001) · Annual Review of Materials Research · doi:10.1146/annurev.matsci.31.1.81 · Cited by 1,465
Resolution of in flammation: state of the art, definitions and terms
Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., & Wallace, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7227rev · Cited by 1,045
“Clearly, disturbances in such counter-regulatory circuits could lead to exacerbated inflammatory responses just as effectively (although perhaps less obviously) than excessive activation of the pro-inflammatory cascades (6).”
BackgroundToll-like receptors stimulate human neutrophil function
Hayashi, F., Means, T. K., & Luster, A. D. (2003) · Blood · doi:10.1182/blood-2003-04-1078 · Cited by 939
RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis
Hasturk, H., Kantarci, A., Ohira, T., Arita, M., Ebrahimi, N., Chiang, N., Petasis, N. A., Levy, B. D., Serhan, C. N., & Van Dyke, T. E. (2006) · The FASEB Journal · doi:10.1096/fj.05-4724fje · Cited by 435
Metadata
- Authors
- Bleich, H. L., Moore, M. J., Weissmann, G., Smolen, J. E., & Korchak, H. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-07-03
- Volume
- 303
- Issue
- 1
- Pages
- 27-34
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2079790969
- Cited by
- 654
- References
- 0
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Release of Inflammatory Mediators from Stimulated Neutrophils. https://app.cochat.ai/papers/10.1056/nejm198007033030109
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- Bleich, H. L., Moore, M. J., Weissmann, G., Smolen, J. E., & Korchak, H. M. (1980). Release of Inflammatory Mediators from Stimulated Neutrophils. New England Journal of Medicine. https://doi.org/10.1056/nejm198007033030109
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
