The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis
Abstract
Periodontitis is a well‐appreciated example of leukocyte‐mediated bone loss and inflammation that has pathogenic features similar to those observed in other inflammatory diseases such as arthritis. Resolvins are a new family of bioactive products of omega‐3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammatory signals. Because it is now increasingly apparent that local inflammation plays a critical role in many diseases, including cardiovascular disease, atherosclerosis, and asthma, experiments were undertaken to evaluate the actions of the newly described EPA‐derived Resolvin E1 (RvE1) in regulation of neutrophil tissue destruction and resolution of inflammation. The actions of an aspirin‐triggered lipoxin (LX) analog and RvE1 in a human disease, localized aggressive periodontitis (LAP), were determined. Results indicate that neutrophils from LAP are refractory to anti‐inflammatory molecules of the LX series, whereas LAP neutrophils respond to RvE1. In addition, RvE1 specifically binds to human neutrophils at a site that is functionally distinct from the LX receptor. Consistent with these potent actions, topical application of RvE1 in rabbit periodontitis conferred dramatic protection against inflammation induced tissue and bone loss associated with periodontitis.
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Citations
Cites
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Self-citationLipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453
Self-citationBlood Levels of Long-Chain n–3 Fatty Acids and the Risk of Sudden Death
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Self-citationFish consumption and major depression
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Cited by
Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041
Self-citationResolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
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Resolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996
Self-citationThe role of the microbiota in periodontal disease
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Metadata
- Authors
- Hasturk, H., Kantarci, A., Ohira, T., Arita, M., Ebrahimi, N., Chiang, N., Petasis, N. A., Levy, B. D., Serhan, C. N., & Van Dyke, T. E.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2005-12-22
- Volume
- 20
- Issue
- 2
- Pages
- 401-403
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2165433466
- Cited by
- 435
- References
- 32
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hasturk, H., Kantarci, A., Ohira, T., Arita, M., Ebrahimi, N., Chiang, N., Petasis, N. A., Levy, B. D., Serhan, C. N., & Van Dyke, T. E. (2006). RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis. The FASEB Journal. https://doi.org/10.1096/fj.05-4724fje
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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