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Cited by 481Urinary Tract Infections ManagementReproductive tract infections researchUrinary Bladder and Prostate Research

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Causes of the Acute Urethral Syndrome in Women

Stamm, Walter E., Wagner, Kenneth F., Amsel, Richard, Alexander, E. Russell, Turck, Marvin, Counts, George W., Holmes, King K.·1980·New England Journal of Medicine
DOI 10.1056/nejm198008213030801
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Abstract

To determine the cause of the acute urethral syndrome, we studied 59 women with dysuria and frequent urination without "significant bacteriuria" (defined as greater than or equal to 10(5) organisms per milliliter), 35 women with typical cystitis and 66 women with no symptoms of urinary-tract infection. Although none of the 59 women with urethral syndrome had greater than 3.4 x 10(4) bacteria per milliliter in either of two successive midstream urine specimens, samples of bladder urine obtained by suprapubic aspiration or catheterization from 24 women contained coliforms, and samples from three contained Staphylococcus saprophyticus; all but one of these 27 women also had pyuria. Of the 32 women with sterile bladder urine, 10 of 16 with pyuria and one of 16 without pyuria were infected with Chlamydia trachomatis (P = 0.002). Chlamydial infection was found in 11 of 42 women with urethral syndrome and pyuria, in three of 66 without symptoms, and in one of 35 with cystitis (P less than 0.01 when the group with urethral syndrome is compared with either of the other groups). Thus, 42 of 59 women with urethral syndrome had abnormal pyuria and 37 of these 42 were infected with coliforms, S. saprophyticus, or C. trachomatis, whereas few women without pyuria had demonstrable infection. Bacteriuria of greater than or equal to 10(5) per milliliter may be an insensitive diagnostic criterion when applied to symptomatic lower-urinary-tract infection.

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Crossref · 10.1056/nejm198008213030801

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Research works printed but not linked: 7

  1. 1977, Adv Data, 12, 1
  2. Wentworth, 1973, Health Lab Sci, 10, 75
  3. Paavonen, 1978, Br J Vener Dis, 54, 257
  4. Stamey, 1971, Calif Med, 115, 1
  5. Kass, 1956, Trans Assoc Am Physicians, 69, 56
  6. Brooks, 1972, J R Coll Gen Pract, 22, 695
  7. 10.1001/archinte.138.7.1069 · DOI

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Metadata

Authors
Stamm, W. E., Wagner, K. F., Amsel, R., Alexander, E. R., Turck, M., Counts, G. W., & Holmes, K. K.
Affiliations
University of Washington (US)
ORCID
Holmes, King K.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1980-08-21
Volume
303
Issue
8
Pages
409-415
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198008213030801
OpenAlex
W2006426891
Cited by
481
References
27
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 2 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 3 · 2015: 10 · 2014: 7 · 2013: 10 · 2012: 5
FWCI
32.98
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Urology › Urinary Tract Infections Management
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
dysuria, pyuria, Chlamydia trachomatis, Staphylococcus saprophyticus, coliform bacteria, bacteriuria, lower urinary tract infection, cystitis, women, suprapubic aspiration
MeSH terms
Acute Disease, Adolescent, Adult, Aged, Antibody-Coated Bacteria Test, Urinary, Bacteria, Bacteriuria, Urinary Bladder, Cervix Uteri, Chlamydia Infections, Chlamydia trachomatis, Cystitis, Escherichia coli Infections, Female, Humans, Male, Middle Aged, Pyuria, Sexually Transmitted Diseases, Syndrome, Urethra, Urethral Diseases, Urinary Tract Infections, Urination Disorders, Urine

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