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Effect of Age on the Response of the Left Ventricular Ejection Fraction to Exercise
Abstract
To assess the effects of age on the left ventricular ejection fraction (LVEF), we performed radionuclide angiocardiography at rest and during upright bicycle exercise in 77 healthy volunteers 20 to 95 years of age. Radionuclide measurements included left ventricular ejection fraction, end-diastolic volume, and regional wall motion. Age did not appear to influence any of these indexes at rest. However, during exercise the ejection fraction was less than 0.60 in 45 per cent of subjects over age 60 as compared with 2 per cent of younger subjects (P < 0.001). In addition, there was a decline in the change in LVEF (exercise LVEF minus rest LVEF) with increase in age (r = -0.71). Wall-motion abnormalities during exercise occurred with increasing frequency in patients who were 50 and older. In the older subjects these age-related changes in ejection fraction during exercise were not associated with differences in end-diastolic volume or blood pressure.
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Cited by
Fletcher, G. F., Ades, P. A., Kligfield, P., Arena, R., Balady, G. J., Bittner, V. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829b5b44 · Cited by 2,235
Fletcher, G. F., Balady, G. J., Amsterdam, E. A., Chaitman, B., Eckel, R., Fleg, J., Froelicher, V. F., Leon, A. S., Piña, I. L., Rodney, R., et al. (2001) · Circulation · doi:10.1161/hc3901.095960 · Cited by 1,923
Cardiovascular responses to exercise. Effects of aging and exercise training in healthy men
Stratton, J. R., Levy, W. C., Cerqueira, M. D., Schwartz, R. S., & Abrass, I. B. (1994) · Circulation · doi:10.1161/01.cir.89.4.1648 · Cited by 449
Metadata
- Authors
- Port, S., Cobb, F. R., Coleman, R. E., & Jones, R. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-11-13
- Volume
- 303
- Issue
- 20
- Pages
- 1133-1137
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2335913961
- Cited by
- 353
- References
- 0
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of Age on the Response of the Left Ventricular Ejection Fraction to Exercise. https://app.cochat.ai/papers/10.1056/nejm198011133032001
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- Port, S., Cobb, F. R., Coleman, R. E., & Jones, R. H. (1980). Effect of Age on the Response of the Left Ventricular Ejection Fraction to Exercise. New England Journal of Medicine. https://doi.org/10.1056/nejm198011133032001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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