The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Streptozocin Alone Compared with Streptozocin plus Fluorouracil in the Treatment of Advanced Islet-Cell Carcinoma
Abstract
To evaluate the treatment of advanced islet-cell carcinoma, we randomly assigned 84 patients to streptozocin alone or streptozocin plus fluorouracil. Each regimen was given in five-day courses. The most frequent toxic effects were nausea and vomiting, mild and reversible renal toxicity, and bone-marrow depression with the combination regimen. The combination had advantages over streptozocin alone in overall rate of response (63 vs. 36 per cent) and in rates of complete response (33 vs. 12 per cent). There was no evidence of a preferential response among types of functional tumors. Objective responses were generally of long duration (median, 17 months) and of substantive clinical benefit. Treatment with the combination also yielded a survival advantage over treatment with streptozocin alone (medians, 26 and 16 1/2 months), but this difference is not statistically significant. In spite of gastrointestinal side effects, streptozocin combined with fluorouracil appears to be a valuable treatment for advanced islet-cell carcinoma.
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Citations
Cites
Pancreatic Islet Cell Carcinoma: II. Results of Therapy with Streptozotocin in 52 Patients
BRODER, L. E., & CARTER, S. K. (1973) · Annals of Internal Medicine · doi:10.7326/0003-4819-79-1-108 · Cited by 349
Clinical antitumor activity and toxicity of streptozotocin (NSC-85998)
Schein, P. S., O'Connell, M. J., Blom, J., Hubbard, S., Magrath, I. T., Bergevin, P., Wiernik, P. H., Ziegler, J. L., & Devita, V. T. (1974) · Cancer · doi:10.1002/1097-0142(197410)34:4<993::aid-cncr2820340404>3.0.co;2-t · Cited by 190
Cited by
Pavel, M., Baudin, E., Couvelard, A., Krenning, E., Öberg, K., Steinmüller, T., Anlauf, M., Wiedenmann, B., & Salazar, R. (2012) · Neuroendocrinology · doi:10.1159/000335597 · Cited by 873
The diagnosis and medical management of advanced neuroendocrine tumors.
Kaltsas, G. A., Besser, G. M., & Grossman, A. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0014 · Cited by 674
Kwekkeboom, D. J., Teunissen, J. J., Bakker, W. H., Kooij, P. P., de Herder, W. W., Feelders, R. A., van Eijck, C. H., Esser, J.-P., Kam, B. L., & Krenning, E. P. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.08.066 · Cited by 657
Gastroenteropancreatic Neuroendocrine Tumors
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Öberg, K., & Eriksson, B. (2005) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2005.06.002 · Cited by 543
Metadata
- Authors
- Moertel, C. G., Hanley, J. A., & Johnson, L. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1980-11-20
- Volume
- 303
- Issue
- 21
- Pages
- 1189-1194
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2340185896
- Cited by
- 659
- References
- 2
- FWCI
- 11.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Streptozocin Alone Compared with Streptozocin plus Fluorouracil in the Treatment of Advanced Islet-Cell Carcinoma. https://app.cochat.ai/papers/10.1056/nejm198011203032101
- The paper
- Moertel, C. G., Hanley, J. A., & Johnson, L. A. (1980). Streptozocin Alone Compared with Streptozocin plus Fluorouracil in the Treatment of Advanced Islet-Cell Carcinoma. New England Journal of Medicine. https://doi.org/10.1056/nejm198011203032101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
