The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Pancreatic Islet Cell Carcinoma: II. Results of Therapy with Streptozotocin in 52 Patients
Abstract
The clinical experience with streptozotocin (NSC-85998) in 52 patients with metastatic islet cell carcinoma was analyzed. The drug was given intravenously in 44 patients and intra-arterially in 8 patients, most often on a weekly schedule of administration of 0.6 to 1.0 g/m2 body surface area. Biochemical responses were seen in 64% of evaluable functional cases, and measurable disease responses were seen in 50% of these cases. Insulin responses occurred 2 to 3 weeks after drug administration at a total dose of about 2 to 4 g/m2 body surface area. A significant increase in 1-year survival rate and a doubling of median survival were shown for the responders as compared with the nonresponders. Acute toxicity, consisting of nausea and vomiting, was observed in 98% of the cases, whereas renal or hepatic toxicity was seen in 65% and 67% of the cases, respectively. Hematological toxicity, observed in 20% of the cases, was mild. Renal and hepatic toxicity were usually reversible, but five patients died in renal failure.
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Cites
Maximum utilization of the life table method in analyzing survival
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Hutter, A. M., & Kayhoe, D. E. (1966) · The American Journal of Medicine · doi:10.1016/0002-9343(66)90220-8 · Cited by 271
Herr, R. R., Jahnke, H. K., & ARGOUDELIS, A. D. (1967) · Journal of the American Chemical Society · doi:10.1021/ja00994a053 · Cited by 217
Katzen, H. M., Soderman, D. D., & Wiley, C. E. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62888-1 · Cited by 169
Pancreatic Islet Cell Carcinoma
Broder, L. E., & Carter, S. K. (1973) · Annals of Internal Medicine · doi:10.7326/0003-4819-79-1-101 · Cited by 149
Self-citationStreptozotocin, a new antibacterial antibiotic.
Vavra, J. J., DeBoer, C., Dietz, A., Hanka, L. J., & Wt, S. (1959) · PubMed · Cited by 146
Streptozotocin: depression of mouse liver pyridine nucleotides.
Schein, P. S., & Loftus, S. (1968) · PubMed · Cited by 134
Clinical Use of Diazoxide and Mechanism for Its Hyperglycemic Effects
Graber, A. L., Porte, D., & Williams, R. H. (1966) · Diabetes · doi:10.2337/diab.15.3.143 · Cited by 95
Diabetogenic Effects of Streptozotocin in Rhesus Monkeys
Pitkin, R. M., & Reynolds, W. A. (1970) · Diabetes · doi:10.2337/diab.19.2.85 · Cited by 89
CONTROL OF HYPOGLYCqMIA WITH DIAZOXIDE AND HUMAN GROWTH HORMONE
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The diagnosis and medical management of advanced neuroendocrine tumors.
Kaltsas, G. A., Besser, G. M., & Grossman, A. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0014 · Cited by 674
Moertel, C. G., Hanley, J. A., & Johnson, L. A. (1980) · New England Journal of Medicine · doi:10.1056/nejm198011203032101 · Cited by 659
Well-differentiated pancreatic neuroendocrine tumors: from genetics to therapy
de Wilde, R. F., Edil, B. H., Hruban, R. H., & Maitra, A. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.9 · Cited by 122
Metadata
- Authors
- BRODER, L. E., & CARTER, S. K.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1973-07-01
- Volume
- 79
- Issue
- 1
- Pages
- 108-118
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1967612457
- Cited by
- 349
- References
- 15
- FWCI
- 23.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- BRODER, L. E., & CARTER, S. K. (1973). Pancreatic Islet Cell Carcinoma: II. Results of Therapy with Streptozotocin in 52 Patients. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-79-1-108
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
