The DOI matches its Crossref record.
Inhibition of Hypoxic Pulmonary Vasoconstriction by Nifedipine
Abstract
SEVERE pulmonary hypertension mainly due to hypoxic vasoconstriction may develop in patients with chronic airflow obstruction and acute respiratory failure.1 Experiments in isolated rat lungs have implied that the calcium antagonist verapamil inhibits hypoxic pulmonary vasoconstriction.2 A preliminary report on patients with hypoxia suggests that verapamil causes an immediate drop in pulmonary vascular resistance.3 However, the concomitant fall in cardiac output may be hazardous in these severely hypoxic subjects. Nifedipine, a new calcium antagonist, causes few side effects4 and is a powerful vasodilating agent of systemic vessels5; as a result it usually increases cardiac output in both normal subjects . . .
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Cited by
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N., Humbert, M., Vachiery, J.-L., Gibbs, S., Lang, I., Torbicki, A., Simonneau, G., Peacock, A., Vonk Noordegraaf, A., Beghetti, M., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv317 · Cited by 6,931
Self-citationPrevention of High-Altitude Pulmonary Edema by Nifedipine
Bartsch, P., Maggiorini, M., Ritter, M., Noti, C., Vock, P., & Oelz, O. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110313251805 · Cited by 451
Metadata
- Authors
- Simonneau, G., Escourrou, P., Duroux, P., & Lockhart, A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-06-25
- Volume
- 304
- Issue
- 26
- Pages
- 1582-1585
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2061098585
- Cited by
- 274
- References
- 0
- FWCI
- 27.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of Hypoxic Pulmonary Vasoconstriction by Nifedipine. https://app.cochat.ai/papers/10.1056/nejm198106253042606
- The paper
- Simonneau, G., Escourrou, P., Duroux, P., & Lockhart, A. (1981). Inhibition of Hypoxic Pulmonary Vasoconstriction by Nifedipine. New England Journal of Medicine. https://doi.org/10.1056/nejm198106253042606
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
