The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Reversible Inhibition of Testicular Steroidogenesis and Spermatogenesis by a Potent Gonadotropin-Releasing Hormone Agonist in Normal Men: An Approach toward the Development of a Male Contraceptive
Abstract
We studied the antifertility effects of a potent gonadotropin-releasing hormone agonist, D-Trp6-Pro9-N-ethylamide-LHRH (LHRHA) in eight normal men, who received daily subcutaneous injections for six to 10 weeks. Plasma testosterone levels fell substantially in all eight. Plasma 17-hydroxyprogesterone and serum estradiol-17 beta levels decreased concordantly with plasma testosterone. Impotence developed in five men between the sixth and seventh weeks of treatment, with resolution in each case within two weeks of stopping treatment. Serum gonadotropin levels also fell during treatment, briefly rebounding above basal levels when therapy ended. Sperm density and motility fell t a nadir during the seventh to 18th week after therapy. In six subjects sperm levels fell to 6 X 10(6) sperm per milliliter or less, and in the other two they decreased 70 and 86 per cent below basal mean values. Sperm density returned to pretreatment levels in all men during the 10-to-14-week recovery period. These results are consistent with LHRHA-induced pituitary "desensitization" but do not exclude a direct inhibitory effect of LHRHA on testicular steroidogenesis and spermatogenesis.
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Citations
Cites
The Neuroendocrine Control of the Menstrual Cycle
KNOBIL, E. (1980) · Proceedings of the 1979 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571136-4.50008-5 · Cited by 1,285
Antifertility Effects of LHRH Agonists in the Male
LABRIE, F., BÉLANGER, A., CUSAN, L., SEGUIN, C., PELLETIER, G., KELLY, P. A., REEVES, J. J., LEFEBVRE, F., LEMAY, A., GOURDEAU, Y., et al. (1980) · Journal of Andrology · doi:10.1002/j.1939-4640.1980.tb00034.x · Cited by 195
Casper, R. F., & Yen, S. S. C. (1979) · Science · doi:10.1126/science.377491 · Cited by 190
Extra-pituitary inhibition of testicular function by luteinising hormone releasing hormone
Hsueh, A. J. W., & Erickson, G. F. (1979) · Nature · doi:10.1038/281066a0 · Cited by 159
THE EFFECT OF HYPERPYREXIA UPON SPERMATOZOA COUNTS IN MEN
Macleod, J., & Hotchkiss, R. S. (1941) · Endocrinology · doi:10.1210/endo-28-5-780 · Cited by 144
Crowley, W. F., Beitins, I. Z., Vale, W., Kliman, B., Rivier, J., RIVIER, C. L., & McArthur, J. W. (1980) · New England Journal of Medicine · doi:10.1056/nejm198005083021903 · Cited by 127
Self-citationAntireproductive Effects of a Potent Gonadotropin-Releasing Hormone Antagonist in the Male Rat
RIVIER, C. L., Rivier, J., & Vale, W. (1980) · Science · doi:10.1126/science.6774418 · Cited by 70
Self-citationGonadal dysfunction in adult men with congenital adrenal hyperplasia
Moore, G. W., Lacroix, A., Rabin, D. U., & McKenna, T. J. (1980) · European Journal of Endocrinology · doi:10.1530/acta.0.0950185 · Cited by 32
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Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Pinilla, L., Aguilar, E., Dieguez, C., Millar, R. P., & Tena-Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 801
Leuprolide versus Diethylstilbestrol for Metastatic Prostate Cancer
The Leuprolide Study Group (1984) · New England Journal of Medicine · doi:10.1056/nejm198411153112004 · Cited by 622
Hot Flashes: Epidemiology and Physiology a
KRONENBERG, F. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb30316.x · Cited by 601
MONROE, S. E., BLUMENFELD, Z., ANDERYKO, J. L., SCHRIOCK, E., HENZL, M. R., & JAFFE, R. B. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-6-1334 · Cited by 66
Metadata
- Authors
- Linde, R., Doelle, G. C., Alexander, N., Kirchner, F., Vale, W., Rivier, J., & Rabin, D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-09-17
- Volume
- 305
- Issue
- 12
- Pages
- 663-667
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1980806708
- Cited by
- 290
- References
- 8
- FWCI
- 32.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reversible Inhibition of Testicular Steroidogenesis and Spermatogenesis by a Potent Gonadotropin-Releasing Hormone Agonist in Normal Men: An Approach toward the Development of a Male Contraceptive. https://app.cochat.ai/papers/10.1056/nejm198109173051203
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- Linde, R., Doelle, G. C., Alexander, N., Kirchner, F., Vale, W., Rivier, J., & Rabin, D. (1981). Reversible Inhibition of Testicular Steroidogenesis and Spermatogenesis by a Potent Gonadotropin-Releasing Hormone Agonist in Normal Men: An Approach toward the Development of a Male Contraceptive. New England Journal of Medicine. https://doi.org/10.1056/nejm198109173051203
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
